Flow Chemistry: A Sustainable Voyage Through the Chemical Universe en Route to Smart Manufacturing DOI Creative Commons
Amanda A. Volk, Zachary S. Campbell, Malek Y. S. Ibrahim

et al.

Annual Review of Chemical and Biomolecular Engineering, Journal Year: 2022, Volume and Issue: 13(1), P. 45 - 72

Published: March 9, 2022

Microfluidic devices and systems have entered many areas of chemical engineering, the rate their adoption is only increasing. As we approach adapt to critical global challenges face in near future, it important consider capabilities flow chemistry its applications next-generation technologies for sustainability, energy production, tailor-made specialty chemicals. We present introduction microfluidics into fundamental unit operations engineering. discuss traits advantages microfluidic approaches different reactive systems, both well-established emerging, with a focus on integration modular high-efficiency experimental platforms accelerated process optimization intensified continuous manufacturing. Finally, current state new horizons self-driven experimentation intelligent exploration through universe distributed

Language: Английский

Droplet-based microfluidics DOI
Thomas Moragues, Diana Arguijo, Thomas Beneyton

et al.

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: April 20, 2023

Language: Английский

Citations

137

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation DOI Creative Commons
Sara Gimondi, Helena Ferreira, Rui L. Reis

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14205 - 14228

Published: July 27, 2023

The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment diseases which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up many disorders. However, to harness their full capabilities, they must be precisely designed, produced, tested relevant models. Microfluidic systems simulate dynamic fluid flows, gradients, specific microenvironments, multiorgan complexes, providing an efficient cost-effective approach both synthesis screening. technologies allow under controlled conditions, enhancing batch-to-batch reproducibility. Moreover, due versatility microfluidic devices, it is possible generate customize endless platforms rapid vitro vivo screening NPs' performance. Indeed, devices show potential as advanced small organism manipulation immobilization. In this review, first we summarize major that synthesis. Next, will discuss most innovative enable mimicking environments well give insights into organism-on-a-chip promising application We conclude review with a critical assessment current challenges future directions impact field nanomedicine.

Language: Английский

Citations

126

Emerging Biosensing Technologies for the Diagnostics of Viral Infectious Diseases DOI Creative Commons
Gözde Kabay, Jonalyn DeCastro,

Alara Altay

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(30)

Published: March 14, 2022

Abstract Several viral infectious diseases appear limitless since the beginning of 21 st century, expanding into pandemic lengths. Thus, there are extensive efforts to provide more efficient means diagnosis, a better understanding acquired immunity, and improved monitoring inflammatory biomarkers, as these all crucial for controlling spread infection while aiding in vaccine development improving patient outcomes. In this regard, various biosensors have been developed recently streamline pathogen immune response detection by addressing limitations traditional methods, including isothermal amplification‐based systems lateral flow assays. This review explores state‐of‐the‐art detecting pathogens, serological assays, biomarkers from material perspective, discussing their advantages, limitations, further potential regarding analytical performance, clinical utility, point‐of‐care adaptability. Additionally, next‐generation biosensing technologies that offer sensitivity selectivity, easy handling end‐users highlighted. An emerging example those powered novel synthetic biology tools, such clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR‐associated proteins (Cas), combination integrated devices. Lastly, current challenges discussed roadmap furthering advanced manage future pandemics is provided.

Language: Английский

Citations

84

Facile Access to Fabricate Carbon Dots and Perspective of Large‐Scale Applications DOI

Lintao Chen,

Cai‐Feng Wang, Chang Liu

et al.

Small, Journal Year: 2022, Volume and Issue: 19(31)

Published: Dec. 7, 2022

Abstract Carbon dots (CDs), fluorescent carbon nanoparticles with particle sizes < 10 nm, are constantly being developed for potential large‐scale applications. Recently, methods allow CD synthesis to be carried out on preparation in a controlled fashion potentially important multiple disciplines, including bottom‐up strategy, top‐down method. In this review, the recent progresses research of production CDs and their functionalization summarized. Especially, synthesis, such as preparation, hydrothermal/solvothermal, microwave‐assisted, magnetic hyperthermia microfluidic other methods, along CDs, summarized detail. By promising applications there three aspects have been already reported, enhancing mechanical properties, flame retardancy, energy storage. Also, future development is prospected.

Language: Английский

Citations

79

Machine learning for nanoplasmonics DOI
Jean‐François Masson, John S. Biggins, Emilie Ringe

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(2), P. 111 - 123

Published: Jan. 26, 2023

Language: Английский

Citations

75

Combinatorial synthesis for AI-driven materials discovery DOI
John M. Gregoire, Lan Zhou, Joel A. Haber

et al.

Nature Synthesis, Journal Year: 2023, Volume and Issue: 2(6), P. 493 - 504

Published: March 9, 2023

Language: Английский

Citations

58

Strongly-confined colloidal lead-halide perovskite quantum dots: from synthesis to applications DOI Creative Commons
Junzhi Ye,

Deepika Gaur,

Chenjia Mi

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(16), P. 8095 - 8122

Published: Jan. 1, 2024

Reducing the dimensionality of lead-halide perovskite nanocrystals from 3D to 0D leads fascinating properties. This tutorial review discusses synthesis, optical properties and applications such strongly-confined quantum dots.

Language: Английский

Citations

28

Ready, Set, Flow! Automated Continuous Synthesis and Optimization DOI Open Access
C. Breen, Anirudh M. K. Nambiar, Timothy F. Jamison

et al.

Trends in Chemistry, Journal Year: 2021, Volume and Issue: 3(5), P. 373 - 386

Published: March 7, 2021

Language: Английский

Citations

103

Self‐Driving Platform for Metal Nanoparticle Synthesis: Combining Microfluidics and Machine Learning DOI Creative Commons

Huachen Tao,

Tianyi Wu, Sina Kheiri

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(51)

Published: Sept. 15, 2021

Abstract Many applications of inorganic nanoparticles (NPs), including photocatalysis, photovoltaics, chemical and biochemical sensing, theranostics, are governed by NP optical properties. Exploration identification reaction conditions for the synthesis NPs with targeted spectroscopic characteristics is a time‐, labor‐, resource‐intensive task, as it involves optimization multiple interdependent conditions. Integration machine learning (ML) microfluidics (MF) offers accelerated synthesis. Here, an autonomous ML‐driven, oscillatory MF platform reported. The utilized recipes times different dimensions, conducted characterization, employed ML approaches to analyze yet prioritized characteristics, identified also used develop understanding relationship between This study shows strong potential ML‐driven platforms in materials science paves way automated development.

Language: Английский

Citations

98

Microfluidic devices for synthesizing nanomaterials—a review DOI Creative Commons
Madhusudan B. Kulkarni, Sanket Goel

Nano Express, Journal Year: 2020, Volume and Issue: 1(3), P. 032004 - 032004

Published: Nov. 20, 2020

In recent times, there has been rapid progress and achievement in the development of nanoparticle production a microfluidic environment. Microfluidics technology harnesses fluid mechanics to generate nanoparticles with unique size finely controllable shape that can be used for various applications like drug delivery, biological sciences, healthcare, food industries. The are generally distinguished from fine particles coarse due their smaller material properties chemical, physical, biological, optical. However, conventional methods require bulky instruments, expensive autoclaves, consume more power, high thermal loss, time synthesis. Further, it is very challenging automate, integrate, miniaturize device on single platform synthesizing micro-and nanoscale particles. There considerable advancement devices last few years unveils several features such as portability, transparency operation, controllability, stability marginal reaction volume. microfluidic-based synthesis also allows processing increased efficiency technique by using minimum peripherals its operation. this review article, we have discussed different applications. This summarizes value-chain develop devices, including designs, fabrication techniques, other related methodologies, create controlled selective manner.

Language: Английский

Citations

84