Trends in biotechnology, Journal Year: 2023, Volume and Issue: 42(3), P. 353 - 368
Published: Sept. 28, 2023
Language: Английский
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1135 - 1153
Published: Jan. 1, 2024
This review introduces the development of droplet microfluidics by explaining physical mechanisms generation, discussing various approaches in manipulating droplets, and summarizing key applications material science biological analyses.
Language: Английский
Citations
79
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 486, P. 150324 - 150324
Published: March 14, 2024
Language: Английский
Citations
21
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.
Language: Английский
Citations
11
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Abstract Synthesizing high drug‐loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large‐scale engineered production of such presents even greater difficulties. This study scalable library polyphenol‐amino acid condensates. By selecting amino acids, the enables precise customization key properties, as carrier capacity, bioactivity, other critical attributes, offering versatile range options for various application scenarios. Leveraging properties solvent‐mediated disassembly reassembly condensates achieved an ultra‐high drug loading 86% paclitaxel. For poorly soluble molecules, capacity exceeded 50%, indicating broad applicability. Furthermore, employing continuous microfluidic device, rate can reach 5 mL min −1 (36 g per day), with nanoparticle size precisely tunable polydispersity index (PDI) below 0.2. The polyphenol‐based demonstrates efficient cellular uptake and, in three distinct animal models, has been shown to enhance therapeutic efficacy paclitaxel without significant side effects. streamlined, efficient, approach using microfluidics produce loading, promising strategy nanoformulation drugs.
Language: Английский
Citations
5
Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Centrifugal microfluidics, with its advantages of rapid and precise fluid control without the need for external pressure, is widely applied in point-of-care testing.
Language: Английский
Citations
3
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 937 - 937
Published: June 28, 2023
Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment performing a single reaction within microscale-volume sample, allowing fast with high sensitivity, throughput, low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact microfluidics, particularly focusing on screening development. addition, surveyed methods device fabrication generation/manipulation. We further highlight some promising studies covering synthesis delivery that were updated last 5 years. This review researchers quick guide includes most up-to-date relevant information latest scientific findings development pharmaceutical field.
Language: Английский
Citations
32
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(3), P. 1033 - 1048
Published: Feb. 16, 2024
Sensing systems necessitate automation to reduce human effort, increase reproducibility, and enable remote sensing. In this perspective, we highlight different types of sensing with elements automation, which are based on flow injection sequential analysis, microfluidics, robotics, other prototypes addressing specific real-world problems. Finally, discuss the role computer technology in systems. Automated techniques offer precise efficient sample handling dependable outcomes. They continuous analysis numerous samples, boosting throughput, saving time resources. enhance safety by minimizing contact hazardous chemicals. Microfluidic enhanced control parameters speed. Robotic sampling preparation platforms excel execution intricate, repetitive tasks such as handling, dilution, transfer. These efficiency multitasking, use minimal volumes, they seamlessly integrate analytical instruments. Other sensor utilize mechanical devices address issues, offering efficient, accurate, economical real-time solutions for analyte identification quantification areas. Computer is crucial modern systems, enabling data acquisition, signal processing, storage. Machine learning artificial intelligence predictions from data, supporting Internet Things management.
Language: Английский
Citations
18
Materials Today, Journal Year: 2024, Volume and Issue: 73, P. 151 - 178
Published: Jan. 30, 2024
Language: Английский
Citations
17
Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 113(7), P. 1726 - 1748
Published: April 4, 2024
The production of paediatric pharmaceutical forms represents a unique challenge within the industry. primary goal these formulations is to ensure therapeutic efficacy, safety, and tolerability in patients, who have specific physiological needs characteristics. In recent years, there has been significant increase attention towards this area, driven by need improve drug administration children optimal treatments. Technological innovation played crucial role meeting requirements, opening new frontiers design forms. particular, three emerging technologies garnered considerable interest scientific industrial community: 3D printing, prilling/vibration, microfluidics. These offer advanced approaches for design, production, customization forms, allowing more precise dosage modulation, improved solubility, greater acceptability. review, we delve into cutting-edge their impact on We analyse potential, associated challenges, developments, providing comprehensive overview opportunities that innovative methodologies sector. examine different generated using techniques, evaluating advantages disadvantages.
Language: Английский
Citations
15
Nano Energy, Journal Year: 2024, Volume and Issue: 127, P. 109766 - 109766
Published: May 18, 2024
Language: Английский
Citations
15