Transparent neural implantable devices: a comprehensive review of challenges and progress

npj Flexible Electronics, Journal Year: 2022, Volume and Issue: 6(1)

Published: June 29, 2022

Abstract The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods a single tool. In conjunction with integration electrophysiology optical modalities, transparent neural interface alleviates challenges conventional metal-based microelectrodes. this review, multimodal sensing stimulation functionalities recent research are addressed. Next, issues that arise when combining metal-based, opaque electrode arrays together modalities—(1) photoelectric artifacts, (2) image blocking, (3) light transmission efficiency—are introduced. Then, introduction advancing material candidates for interfaces follows latest research.

Language: Английский

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Intrinsically Nonswellable Multifunctional Hydrogel with Dynamic Nanoconfinement Networks for Robust Tissue‐Adaptable Bioelectronics

Advanced Science, Journal Year: 2023, Volume and Issue: 10(12)

Published: Feb. 17, 2023

Developing bioelectronics that retains their long-term functionalities in the human body during daily activities is a current critical issue. To accomplish this, robust tissue adaptability and biointerfacing of should be achieved. Hydrogels have emerged as promising materials for can softly adapt to interface with tissues. However, hydrogels lack toughness, requisite electrical properties, fabrication methodologies. Additionally, water-swellable property weakens mechanical properties. In this work, an intrinsically nonswellable multifunctional hydrogel exhibiting tissue-like moduli ranging from 10 100 kPa, toughness (400-873 J m

Language: Английский

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Developing conductive hydrogels for biomedical applications

Smart Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: Sept. 15, 2023

Conductive hydrogels have attracted copious attention owing to their grateful performances, such as similarity biological tissues, compliance, conductivity and biocompatibility. A diversity of conductive been developed showed versatile potentials in biomedical applications. In this review, we highlight the recent advances hydrogels, involving various types functionalities well applications fields. Furthermore, current challenges reasonable outlook are also given. It is expected that review will provide potential guidance for advancement next-generation hydrogels.

Language: Английский

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Conformal Fixation Strategies and Bioadhesives for Soft Bioelectronics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Jan. 6, 2024

Abstract Flexible wearable and implantable devices are contributing to the healthcare field by enabling intuitive interfaces with tissues of human body through their thin form factors, which enable more accurate monitoring signals effective delivery therapy. The development such is accompanied an increasing interest in strategies technologies for conformally fixing adhering flexible biomedical place acquire high‐quality biosignals over a long period, even subtle movements target. Owing various mechanical properties wet or dynamic environments tissues, it necessary use different adhesion that consider biocompatibility cohesive each case. This paper provides in‐depth analysis recent bio‐adhesives practical applications classifying them into: 1) Conventional Fixation, 2) Mechanical 3) Chemical Adhesion, based on mechanism, 4) Functional Adhesion 5) Biomimetic unique properties. Furthermore, principles detailed mechanisms strategy design characteristics bioadhesives thoroughly reviewed provide valuable insights overall summary prospects challenges future technology.

Language: Английский

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A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Abstract Signal communication mechanisms within the human body rely on transmission and modulation of action potentials. Replicating interdependent functions receptors, neurons synapses with organic artificial biohybrid is an essential first step towards merging neuromorphic circuits biological systems, crucial for computing at interface. However, most systems are based simple which exhibit limited adaptability to both external internal cues, restricted emulate only specific individual neuron/synapse. Here, we present a modular system combines spiking replicate neural pathway. The neuron mimics sensory coding function afferent from light stimuli, while neuromodulatory activity interneurons emulated by neurotransmitters-mediated synapses. Combining these functions, create connection between multiple establish pre-processing retinal pathway primitive.

Language: Английский

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Current and emerging strategies for biocompatible materials for implantable electronics

Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(8), P. 101852 - 101852

Published: March 5, 2024

The application of electronics to biological systems has rapidly developed over the last century, facilitating significant advances in diagnosis and therapy a large range conditions. electrodes within these devices are crucial component enabling high-quality, low noise signal recordings be achieved. However, most traditional materials used maximize electrical properties often at odds with need integrate interface successfully tissue. This review provides an overview current considerations, challenges, progress bypassing barriers vivo through material selection fabrication, by considering performance requirements implantable electrode practical limitations imposed fabrication technologies. We then summarize state-of-the-art emerging for electrodes.

Language: Английский

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Conducting polymer scaffolds: a new frontier in bioelectronics and bioengineering

Trends in biotechnology, Journal Year: 2024, Volume and Issue: 42(6), P. 760 - 779

Published: Jan. 5, 2024

Conducting polymer (CP) scaffolds have emerged as a transformative tool in bioelectronics and bioengineering, advancing the ability to interface with biological systems. Their unique combination of electrical conductivity, tailorability, biocompatibility surpasses capabilities traditional nonconducting while granting them access realm bioelectronics. This review examines recent developments CP scaffolds, focusing on material device advancements, well their interplay We highlight applications for monitoring, tissue stimulation, drug delivery discuss perspectives challenges currently faced ultimate translation clinical implementation.

Language: Английский

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Wearable heart rate variability analysis system based on ionic conductive hydrogels

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127591 - 127591

Published: Jan. 18, 2025

Language: Английский

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Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101508 - 101508

Published: Jan. 1, 2025

Language: Английский

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Electrode- and Label-Free Assessment of Electrophysiological Firing Rates through Cytochrome C Monitoring via Raman Spectroscopy

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

In vitro neurotoxicology aims to assess and predict the side effects of exogenous chemicals toward human brain. Among exploited approaches, electrophysiological techniques stand out for high spatiotemporal resolution sensitivity, with patch clamp considered gold standard technique such purposes. However, structural toxicity metabolic may elude detection when only electrical activity is measured, highlighting need integrating recordings complementary approaches as optical methods. this study, we describe an integrated platform recording neuronal performing chemical analysis a noninvasive label-free imaging, Raman spectroscopy. Specifically, developed protocol that maximizes signal-to-noise ratio while avoiding crosstalk spectroscopical readouts any phototoxicity associated laser exposure. Synchronous sequential electrical–optical measurements were carried compared, approach being more suitable longitudinal investigation correlation intracellular content reduced cytochrome C, lipids, proteins, nucleic acids. Data shows strong between status single cells overall firing rate, suggesting electrode- assessment rates through monitoring C via spectroscopy multielectrode array devices noise impedance are used. Conversely, rate not correlated Thus, study demonstrates downstream upstream features de novo synthesis acids, provides additional information accurate acute chronic neurotoxicity.

Language: Английский

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