European Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
2020(15), P. 2155 - 2179
Published: March 18, 2020
Quinolines
and
their
derivatives
have
always
been
promising
leads
for
drug
discovery,
material
applications
designing
new
catalysts.
In
the
past
decade,
C(sp
3
)‐H
functionalization
of
2‐methyl
azaarenes,
particularly
quinolines,
has
become
one
highly
facile
synthetic
routes
generation
chemical
libraries
quinolines.
this
minireview,
we
showcase
endeavors
on
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 3413 - 3418
Published: Feb. 20, 2024
An
efficient
cascade
intramolecular
cyclization/intermolecular
nucleophilic
addition
reaction
of
allenyl
benzoxazinone
with
isatin
or
isatin-derived
ketimine
has
been
established
by
using
Pd0-π-Lewis
base
catalysis.
A
series
3-hydroxy-2-oxindoles
and
3-amino-2-oxindoles
quaternary
carbon
atoms
at
the
C3
position
were
synthesized
in
good
yields
under
mild
conditions
through
this
protocol.
Synlett,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
Abstract
We
report
a
metal-free
protocol
for
the
amidation
and
selenoamidation
of
2-methylquinolines
by
using
selenium
dioxide
as
key
reagent.
This
method
offers
several
advantages,
including
ease
operation,
short
reaction
time
(15
min),
moderate
to
excellent
yields
(50–90%).
The
demonstrates
broad
substrate
tolerance,
various
secondary
amines
2-methyl
heterocycles
such
pyridine
benzothiazole.
applicability
was
further
highlighted
through
late-stage
functionalization
ciprofloxacin,
yielding
bioactive
hybrid
molecule
with
remarkable
MIC
value
0.195
μg/mL.
The Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
85(7), P. 4682 - 4694
Published: March 11, 2020
A
single-step,
stereoselective
protocol
for
the
synthesis
of
unsymmetrically
substituted
(E)-3-allylideneoxindole
and
(E)-3-allylidenebenzofuran
from
readily
accessible
starting
materials
using
palladium
binaphthyl
nanoparticles
(Pd-BNPs)
has
been
developed.
Pd-BNP
showing
a
wide
range
functional
group
tolerance
an
immense
array
substrate
scope
have
explored
with
successful
drug
molecule
"tubulin
polymerization
inhibitor"
free
trace
metal
impurities.
The
model
reaction
is
extended
to
gram-scale
synthesis,
one
products
utilized
derivatization.
recycled
up
5
catalytic
cycles
without
any
loss
in
yields
particle
size
nanoparticles.
Asian Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
10(1), P. 202 - 209
Published: Sept. 24, 2020
Abstract
The
development
of
new
methods
for
the
direct
synthesis
bioactive
molecules
is
a
pivotal
topic
in
organic
and
medicinal
chemistry.
Herein,
we
describe
rhodium(III)‐catalyzed
C−H
functionalization
N
‐aryl
phthalazinones
with
maleimides.
complete
site‐selectivity
broad
functional
group
tolerance
are
observed.
Notably,
this
protocol
allows
integration
succinimides,
which
vital
motifs
found
natural
products
pharmaceuticals.
The Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
85(16), P. 10514 - 10524
Published: Aug. 5, 2020
The
binaphthyl
stabilized
palladium
nanoparticles
(Pd-BNP)
catalyzed
single-step,
stereoselective
domino
synthesis
of
symmetrically
and
unsymmetrically
all-carbon
tetrasubstituted
olefin
containing
oxindoles
from
readily
accessible
anilides
has
been
developed.
Pd-BNP
catalyst
showed
a
wide
range
functional
group
tolerance
that
enabled
building
library
heteroaromatics.
This
reusable
Pd
reflected
its
utility
in
the
biologically
important
AMP-activated
protein
kinase
deprived
any
metal
contamination.
nanocatalyst
was
easily
recovered
reused
five
times
without
appreciable
loss
particle
size
or
catalytic
activity.
Journal of Saudi Chemical Society,
Journal Year:
2023,
Volume and Issue:
27(2), P. 101621 - 101621
Published: Feb. 25, 2023
An
environmentally
benign
highly
atom-economic
protocol
for
the
construction
of
CC
bond
has
been
developed
under
catalyst-
and
solvent-free
conditions.
This
involves
efficient
coupling
2-methyl
quinazolinones
with
3-(trifluoroacetyl)coumarins
access
quinazolinone
derivatives
in
excellent
yields
(up
to
90
%).
The
crystal
structure
compound
3di
was
investigated
by
X-ray
diffraction
analysis.
biological
activities,
such
as
vitro
antifungal
activity
against
Fusarium
graminearum,
moniliforme,
oxysporum,
Phytophthora
parasitica
var
nicotianae,
Rhizoctonia
solani
Kuhn,
were
investigated.
bioassay
results
indicated
that
most
target
products
exhibited
promising
fungicidal
3
cl
95
%
R.
solani,
an
EC50
value
10.6
μg/mL.
European Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
2020(27), P. 4134 - 4145
Published: June 8, 2020
Highly
facile
approach
of
chemoselective
alkylation
α‐oxo
compounds
such
as
α‐keto
amides,
esters,
isatins,
and
cyclic‐α‐diketones
is
developed
through
C(sp
3
)‐H
functionalization
2‐methyl
quinolines
under
solvent
catalyst‐free
conditions.
Further,
we
complemented
the
efficacy
this
green
synthetic
protocol
by
demonstrating
broad
substrate
diversity,
gram‐scale
synthesis,
new
transformations
obtained
products.
