European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(43)
Published: Oct. 21, 2022
Abstract
The
hydroxyl‐directed
iridium‐catalyzed
peri
‐selective
C−H
bond
activation
to
synthesize
substituted
pyrano[2,3,4‐
de
]chromen‐2‐ones
and
further
chalcogenylation
under
blue
light
irradiation
has
been
realized
efficiently.
Most
products
of
polycyclic
pyrans
corresponding
chalcogenated
derivatives
with
various
substituents
were
achieved
in
good
excellent
yields.
Preliminary
mechanistic
studies
suggest
that
this
transformation
may
pass
through
a
five‐membered
iridacycle
intermediate
containing
an
O−Ir
σ‐bond
photocatalytic
free
radical
process.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(8), P. 1744 - 1750
Published: Feb. 22, 2024
Abstract
The
transmetalation
triggered
rhodium‐catalyzed
C−H
bond
activation
and
tandem
annulation
of
2‐biphenylboronic
acids
with
sulfoxonium
ylides
or
iodonium
has
been
developed.
Various
products
phenanthrenes
were
constructed
under
redox‐neutral
conditions
in
34–86%
yields.
Several
mechanism
exploration
experiments
derivatization
reactions
conducted
sequence
to
gain
a
deeper
understanding
the
process
potential
this
transformation.
It
offers
an
alternative
approach
for
synthesis
phenanthrene
derivatives.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(22), P. 5717 - 5734
Published: Jan. 1, 2023
Vinylene
carbonate
(VC)
has
emerged
as
a
promising
coupling
partner
to
participate
in
various
attractive
C–H
conversions
and
implement
an
increasing
number
of
novel
reactions.
In
this
review,
we
provide
summary
the
advancements
achieved
metal-catalyzed
functionalization
using
VC.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(11), P. 4282 - 4291
Published: Jan. 1, 2023
The
chemical
upcycling
of
poly(bisphenol
A
carbonate)
was
carried
out
through
organocatalysis
using
α-hydroxyketones
as
nucleophiles,
leading
to
valuable
vinylene
carbonates.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(20), P. 3400 - 3412
Published: Sept. 6, 2023
Abstract
Recently,
vinylene
carbonate
has
been
developed
as
a
powerful
synthon
in
transition
metal‐catalyzed
C−H
bond
activation/cyclization
reactions.
This
review
introduces
recent
progress
the
use
of
reactant,
by
analyzing
and
comparing
reaction
models
involving
surrogate
ethynol,
acetylene,
acetylation
reagents
or
other
reactants,
while
addressing
related
mechanisms
synthetic
applications.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 29, 2025
Abstract
Carbazoles
are
an
important
class
of
nitrogen‐containing
heterocycles
found
in
diverse
natural
products,
bioactive
molecules,
and
functional
materials.
Their
broader
applications
have
driven
extensive
research
into
their
synthesis
functionalization.
Among
various
approaches,
transition
metal‐catalyzed
C−H
activation
has
emerged
as
a
powerful
tool
for
direct
functionalization,
offering
regioselectivity,
efficiency,
sustainability.
This
review
comprehensively
summarizes
advancements
functionalization
carbazoles.
Various
catalytic
systems
employing
palladium,
ruthenium,
rhodium,
nickel,
cobalt,
copper,
iron
enabled
alkylation,
alkenylation,
acylation,
arylation,
alkynylation,
heteroatom
incorporation
These
methodologies
late‐stage
diversification
opened
avenues
accessing
structurally
complex
carbazole
derivatives
with
tailored
properties.
The
aims
to
provide
comprehensive
guide
researchers
exploring
via
activation,
highlighting
key
mechanistic
insights,
scope,
emerging
trends
this
field.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(29), P. 5411 - 5415
Published: July 17, 2023
A
cobalt(III)-catalyzed
directed
C-7
alkynylation
of
indolines
with
easily
accessible
bromoalkynes
has
been
developed.
The
reaction
a
broad
substrate
scope
excellent
yields
and
represents
powerful
route
to
the
synthesis
7-alkynyl-substituted
indolines.
In
addition,
can
be
extended
coupling
N-aryl
7-azaindoles,
highlighting
synthetic
practicability
strategy.
Synthesis,
Journal Year:
2023,
Volume and Issue:
55(21), P. 3454 - 3469
Published: March 20, 2023
Abstract
C8-Substituted
quinoline
(QN)
and
1,2,3,4-tetrahydroquinoline
(THQ)
scaffolds
are
featured
in
numerous
bioactive
compounds
natural
products.
Appreciable
efforts
have
been
made
towards
the
development
of
elegant
techniques
to
functionalize
C8–H
bond
QNs
THQs.
The
transition-metal-catalyzed
chelation-assisted
C–H
activation
strategy
has
emerged
as
an
effective
synthetic
tool
among
existing
methods.
This
review
focuses
on
recent
advances
directed
carbon–carbon
forming
reactions
for
functionalization
THQs
(till
February
2023).
discussion
categorized
based
type
reaction.
1
Introduction
2
Acylation
3
Alkylation
4
Alkenylation
5
Alkynylation
6
Allylation
7
Annulation
8
Arylation
9
Conclusion
Outlook
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(50)
Published: June 26, 2023
The
selective
C7-allylation
of
indolines
with
allyl
bromide
under
ruthenium
catalysis
has
been
revealed
here.
Under
established
reaction
conditions,
various
indolines,
including
drug
compounds,
was
accomplished
good
selectivity
and
yields.
Based
on
combined
experimental
density
functional
theory
(DFT)
studies,
the
olefin
insertion
route
energetically
favorable
among
four
possible
pathways.
Experimental
DFT
studies
further
that
C-H
activation
is
a
reversible
rate-limiting
step.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(7), P. 1027 - 1035
Published: March 16, 2023
Abstract
Rh(III)‐catalyzed
chelation‐assisted
C8‐selective
C−H
alkenylation
and
alkylation
of
1,2,3,4‐tretrahydroquinolines
with
styrenes
allylic
alcohols
have
been
realized.
The
cationic
Rh(III)
catalytic
system
in
combination
a
amount
copper
acetate
uses
oxygen
as
the
terminal
oxidant
catalyzes
stereoselective
C8‐alkenylation
1,2,3,4‐tetrahydroquinolines
to
give
corresponding
products
56–93%
yields
wide
substrate
scope
broad
functional
group
compatibility.
reaction
can
be
scaled
up.
Moreover,
this
protocol
extended
C8‐alkylation
alcohols,
providing
access
various
8‐(3‐oxoalkyl)‐1,2,3,4‐tetrahydroquinolines
77–90%
yields.
selection
N‐directing
is
essential
for
catalysis,
readily
installable
removable
N‐(2‐pyrimidyl)
proves
optimal
choice.
Preliminary
mechanistic
studies
are
performed
gain
insights
into
mechanism.
magnified
image
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(98), P. 14559 - 14562
Published: Jan. 1, 2023
A
novel
organic
transformation
involving
rhodium-catalyzed
divergent
dehydroxylation/alkenylation
of
hydroxyisoindolinone
with
vinylene
carbonate
is
reported,
and
the
promising
reagent
presents
a
distinct
chemical
reactivity
as
vinyl-oxygen
cyclic
synthon.
