Electrochemical Trifluoromethylation of Enamides under Microflow Conditions DOI Creative Commons
Anna Vanluchene, Tomas Horsten, Eli Bonneure

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(11), P. 4018 - 4023

Published: Oct. 22, 2024

The development of sustainable trifluoromethylations enamides is great interest to the pharmaceutical industry. Herein, we demonstrate a direct electrochemical trifluoromethylation method in microflow cell, using Langlois reagent, without need for supporting electrolyte, oxidants, or any additive under mild conditions. This can be applied various substrates with yield up 84%. Additionally, batch process yielded significantly less (22%), highlighting cell's efficiency.

Language: Английский

Photoredox-catalyzed three-component carbotrifluoromethylation of alkenes via radical–radical cross-coupling DOI
Lin Tang,

Ge Lv,

Taijun Wu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(17), P. 4708 - 4715

Published: Jan. 1, 2024

A simple and practical visible light-driven photoredox-catalyzed three-component carbotrifluoromethylation of alkenes is revealed for the synthesis 1,4-bis(trifluoromethylated) compounds.

Language: Английский

Citations

3
Oxidative Aminotrifluoromethylation of 1,4-Naphthoquinone DOI
Lin Tang,

Fengjuan Jia,

Ruijun Yu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13117 - 13127

Published: Sept. 3, 2024

A strategy for convenient and precise oxidative aminotrifluoromethylation of 1,4-naphthoquinone with the Togni reagent amines has been demonstrated via a radical process. This method allows efficient access preparation wide range CF

Language: Английский

Citations

2
Electrochemical trifluoromethylation of enamides under microflow conditions DOI Creative Commons
Anna Vanluchene, Tomas Horsten, Eli Bonneure

et al.

Published: Aug. 2, 2024

The development of sustainable trifluoromethylations enamides is great interest to the pharmaceutical industry. Herein, we demonstrate a direct electrochemical trifluoromethylation method in microflow cell, using Langlois reagent, without need supporting electrolyte, oxidants or any additive under mild conditions. This can be applied various substrates with yield up 84%.

Language: Английский

Citations

0
Synthesis of N‑Heterocyclic amides from imidazoheterocycles through convergent paired electrolysis DOI

Elise Leclercq,

Laura Chevet,

Nicolás David

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we present a novel electrochemical approach for the synthesis of N-heterocyclic amides with moderate to excellent yields in batch and flow.

Language: Английский

Citations

0
Electrochemical Trifluoromethylation of Enamides under Microflow Conditions DOI Creative Commons
Anna Vanluchene, Tomas Horsten, Eli Bonneure

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(11), P. 4018 - 4023

Published: Oct. 22, 2024

The development of sustainable trifluoromethylations enamides is great interest to the pharmaceutical industry. Herein, we demonstrate a direct electrochemical trifluoromethylation method in microflow cell, using Langlois reagent, without need for supporting electrolyte, oxidants, or any additive under mild conditions. This can be applied various substrates with yield up 84%. Additionally, batch process yielded significantly less (22%), highlighting cell's efficiency.

Language: Английский

Citations

0