Bisphenol A: Food Exposure and Impact on Human Health

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2018, Volume and Issue: 17(6), P. 1503 - 1517

Published: Sept. 5, 2018

Abstract Bisphenol A (BPA) is an industrial compound used extensively to produce synthetic polymers, such as epoxy resins, which are incorporated into the inner coating of metal cans, and also manufacture polycarbonates with applications in bottles, including bottles water. Several studies have reported on transfer this food. Regarding human exposure BPA, food intake can be considered most serious among all routes, not only because it potentially reaches more people different age groups (including infants, especially vulnerable group), but inadvertently occurs over long time periods. BPA endocrine disruptor several proposed a relationship between appearance adverse health effects, cancer, infertility, diabetes, obesity, others. In 2015 however, European Food Safety Authority concluded its last scientific opinion that does pose any risk exposed population's health. Therefore, EU regards authorized product contact material. Although through apparently below set limits, research potential negative effects still ongoing. This review contains recent vitro vivo toxicity harmful health, intends address namely dietary impact

Language: Английский

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Hazards of bisphenol A (BPA) exposure: A systematic review of plant toxicology studies

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 384, P. 121488 - 121488

Published: Oct. 21, 2019

Language: Английский

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Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

Advanced Science, Journal Year: 2016, Volume and Issue: 4(2)

Published: Nov. 21, 2016

Breast cancer is the fifth most common cause of death in world and second fatal women. Epidemiological studies clinical data have indicated that hormones, including estrogen, progesterone, prolactin, play important roles initiation progression breast cancer. Bisphenol A (BPA) one commonly used thoroughly studied endocrine disruptors. It can be released from consumer products deposited environment, thus creating potential for human exposure through oral, inhaled, dermal routes. Some recent reviews summarized known mechanisms disruptions by BPA diseases, obesity, reproductive disorders, birth defects. However, large knowledge gaps still exist on may development. Evidence animal vitro has suggested an association between increased incidence at doses below safe reference are environmentally relevant. Most current paid little attention to cancer‐promoting properties low doses. In this review, findings carcinogenic effects low‐dose discussed possible biologic summarized.

Language: Английский

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Enrichment and dissemination of bacterial pathogens by microplastics in the aquatic environment

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 830, P. 154720 - 154720

Published: March 23, 2022

Language: Английский

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A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(16), P. 19643 - 19663

Published: March 5, 2021

Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances human exposure predisposing individuals at extremely low doses diseases, including cancer. enters body via oral, inhaled, dermal routes leach-out products. BPA may be anticipated probable carcinogen. Studies using in vitro cell lines, rodent models, epidemiological analysis have convincingly shown increasing susceptibility cancer below oral reference dose set by Environmental Protection Agency BPA. Furthermore, exerts toxicological effects genetic epigenetic levels, influencing various signaling pathways. The present review summarizes available data on potential impact clinical outcome.

Language: Английский

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An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products

Integrated Environmental Assessment and Management, Journal Year: 2022, Volume and Issue: 19(1), P. 45 - 62

Published: April 1, 2022

With over 95% of bisphenol-A (BPA) used in the production polycarbonate (PC) and epoxy resins, termed here as BPA-based plastic materials, components, products (MCPs), an investigation human exposure to BPA whole lifecycle MCPs is necessary. This mini-review unpacks implications arising from long-term its potential accumulation across plastics (production, use, management). timely necessary promoting a sustainable circular economy model. Restrictions form bans safety standards are often specific products, while limits rely on traditional toxicological biomonitoring methods that may underestimate health therefore "safety" exposure. Controversies regards the: (a) dose-response curves; (b) complexity sources, release mechanisms, pathways exposure; and/or (c) quality reliability studies, appear currently stifle progress toward regulation MCPs. Due abundance our production, consumption, management systems, there partial inadequate evidence contribution BPA. Yet, end-of-life constitute most critical source require further investigation. Active collaboration among risk assessors, government, policy-makers, researchers needed explore impacts long term introduce restrictions Integr Environ Assess Manag 2023;19:45-62. © 2022 SETAC.

Language: Английский

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Worldwide risk assessment of phthalates and bisphenol A in humans: The need for updating guidelines

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108294 - 108294

Published: Oct. 28, 2023

Phthalates and bisphenol A (BPA) are compounds widely used as raw materials in the production of plastics, making them ubiquitous our daily lives. This results widespread human exposure health hazards. Although efforts have been conducted to evaluate risk these diverse regions around world, data scattering may mask important trends that could be useful for updating current guidelines regulations. study offers a comprehensive global assessment levels chemicals, considering dietary nondietary ingestion, evaluates associated risk. Overall, intake (EDI) values phthalates BPA reported worldwide ranged from 1.11 × 10−7 3 700 µg kg bw−1 d−1 3.00 10−5 6.56 d−1, respectively. Nevertheless, dose-additive effect has shown increase EDI up 5 100 representing high terms noncarcinogenic (HQ) carcinogenic (CR) effects. The HQ 2.25 3.66 2.74 9.72 10−2, Meanwhile, significant number studies exhibit CR benzyl butyl phthalate (BBP) di(2-ethylhexyl) (DEHP). Moreover, DEHP highest maximum mean humans numerous studies, 179-fold higher than BBP. Despite mounting evidence harmful effects chemicals at low-dose on animals humans, most regulations not updated. Thus, this article emphasizes need public policies compelling adverse exposure, it cautions against use alternative plasticizers substitutes because gaps their safety.

Language: Английский

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Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe

Food and Chemical Toxicology, Journal Year: 2019, Volume and Issue: 131, P. 110575 - 110575

Published: June 12, 2019

Language: Английский

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Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 207, P. 111299 - 111299

Published: Sept. 11, 2020

The analogues of biphenol A (BPA), including bisphenol S (BPS) and B (BPB), are commonly used to replace the application BPA in containers wrappers daily life. However, their safeties questioned due similar chemical structure possible physiological effects as BPA. To investigate neurotoxic BPA, BPS, BPB well underlying mechanism, IMR-32 cell line from male SK-N-SH female were exposed respectively BPS with concentrations 1 nM, 10 100 μM, μM for 24 h. Additionally, h exposure combining epigallocatechin gallate (EGCG) (4 8 respectively) conducted. Results demonstrated that BPs could promote reactive oxygen species production increase level malondialdehyde (MDA) while decrease levels superoxide dismutase (SOD). Intensive study revealed after mitochondrial membrane potential (MMP) dropped down protein expression Bak-1, Bax, cytochrome c Caspase-3 up-regulated but Bcl-2 down-regulated significantly. Moreover, apoptosis rate was raised activity declined remarkably neuroblastoma cells. All induced by be alleviated adding EGCG, which alleviations inferred cells BPB. Furthermore, showed lower compared Interestingly, on significantly higher than those In conclusion, results suggested induce oxidative stress via pathway is more susceptible female.

Language: Английский

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The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Current Molecular Pharmacology, Journal Year: 2019, Volume and Issue: 12(3), P. 230 - 238

Published: March 8, 2019

Bisphenol A (BPA) is a synthetic plasticizer that commonly used in the production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA migrates from food beverage containers into contents heated or even under normal conditions use. exerts endocrine disruptor action due to its weak binding affinity for estrogen receptors ERα ERβ. other effects by activating membrane receptor GPER (GPR30) and/or such as estrogen-related (ERRs).This review summarizes emerging data on cancer. These include linking with an increased risk hormone-related cancers those ovary, breast, prostate, colon can also induce resistance various chemotherapeutics doxorubicin, cisplatin, vinblastine vitro. The development chemoresistance available therapeutics significant aspect toxicity because it worsens prognosis many tumors.Recent findings support causal role at low levels dictating their response cytotoxic therapy. Accurate knowledge consideration these issues would be highly beneficial cancer prevention management.

Language: Английский

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