Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 6, 2024
Abstract
Immunotherapy
with
immune
checkpoint
blockade
(ICB)
for
glioblastoma
(GBM)
is
promising
but
its
clinical
efficacy
seriously
challenged
by
the
blood-tumor
barrier
(BTB)
and
immunosuppressive
tumor
microenvironment.
Here,
anti-programmed
death-ligand
1
antibodies
(aPD-L1)
are
loaded
into
a
redox-responsive
micelle
ICB
further
amplified
paclitaxel
(PTX)-induced
immunogenic
cell
death
(ICD)
via
co-encapsulation
approach
reinvigoration
of
local
anti-GBM
responses.
Consequently,
micelles
cross
BTB
retained
in
reductive
microenvironment
without
altering
bioactivity
aPD-L1.
The
enhanced
aPD-L1
PTX
combination
suppression
primary
recurrent
GBM,
accumulation
cytotoxic
T
lymphocytes,
induction
long-lasting
immunological
memory
orthotopic
GBM-bearing
mice.
facilitating
efficient
antibody
delivery
combining
chemotherapeutic
agent-induced
ICD
demonstrate
that
chemo-immunotherapy
might
reprogram
immunity
to
empower
immunotherapy
against
GBM.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(7), P. 3028 - 3048
Published: March 1, 2022
Compared
with
traditional
drug
therapy,
nanomedicines
exhibit
intriguing
biological
features
to
increase
therapeutic
efficiency,
reduce
toxicity
and
achieve
targeting
delivery.
This
review
provides
a
snapshot
of
that
have
been
currently
launched
or
in
the
clinical
trials,
which
manifests
diversified
trend
carrier
types,
applied
indications
mechanisms
action.
From
perspective
indications,
this
article
presents
an
overview
applications
involving
prevention,
diagnosis
treatment
various
diseases,
include
cancer,
infections,
blood
disorders,
cardiovascular
immuno-associated
diseases
nervous
system
etc.
Moreover,
some
considerations
perspectives
research
development
facilitate
their
translations
clinic.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(7)
Published: Jan. 17, 2023
Abstract
Since
the
insight
to
fuse
Fenton
chemistry
and
nanomedicine
into
cancer
therapy,
great
signs
of
progress
have
been
made
in
field
chemodynamic
therapy
(CDT).
However,
exact
mechanism
CDT
is
obscured
by
unique
tumor
chemical
environment
inevitable
nanoparticle‐cell
interactions,
thus
impeding
further
development.
In
this
Scientific
Perspective,
significance
clarified,
complex
deconstructed
primitive
biological
research
directions
based
on
kinetics
signaling
pathways
are
discussed
detail.
Moreover,
beneficial
outlooks
presented
enlighten
evolution
next‐generation
CDT.
Hopefully,
Perspective
can
inspire
new
ideas
advances
for
provide
a
reference
breaking
down
interdisciplinary
barriers
nanomedicine.
Advanced Drug Delivery Reviews,
Journal Year:
2021,
Volume and Issue:
176, P. 113891 - 113891
Published: July 26, 2021
CRISPR/Cas9
(Clustered
Regularly
Interspaced
Short
Palindromic
Repeats-associated
protein
9)
is
a
potent
technology
for
gene-editing.
Owing
to
its
high
specificity
and
efficiency,
extensity
used
human
diseases
treatment,
especially
cancer,
which
involves
multiple
genetic
alterations.
Different
concepts
of
cancer
treatment
by
are
established.
However,
significant
challenges
remain
clinical
applications.
The
greatest
challenge
therapy
how
safely
efficiently
deliver
it
target
sites
in
vivo.
Nanotechnology
has
greatly
contributed
drug
delivery.
Here,
we
present
the
action
mechanisms
CRISPR/Cas9,
application
focus
on
nanotechnology-based
delivery
gene
editing
immunotherapy
pave
way
translation.
We
detail
difficult
barriers
CRISIR/Cas9
vivo
discuss
relative
solutions
encapsulation,
delivery,
controlled
release,
cellular
internalization,
endosomal
escape.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(19)
Published: Sept. 19, 2022
Abstract
As
an
essential
micronutrient,
manganese
(Mn)
participates
in
various
physiological
processes
and
plays
important
roles
host
immune
system,
hematopoiesis,
endocrine
function,
oxidative
stress
regulation.
Mn‐based
nanoparticles
are
considered
to
be
biocompatible
show
versatile
applications
nanomedicine,
particular
utilized
tumor
immunotherapy
the
following
ways:
1)
acting
as
a
nanocarrier
deliver
immunotherapeutic
agents
for
immunotherapy;
2)
serving
adjuvant
regulate
microenvironment
enhance
3)
activating
host's
system
through
cGAS‐STING
pathway
trigger
4)
real‐time
monitoring
effect
by
magnetic
resonance
imaging
(MRI)
since
Mn
2+
ions
ideal
MRI
contrast
agent
which
can
significantly
T
1
‐weighted
signal
after
binding
proteins.
This
comprehensive
review
focuses
on
most
recent
progress
of
nanoplatforms
immunotherapy.
The
characteristics
first
discussed
guide
design
multifunctional
nanoplatforms.
Then
biomedical
nanoplatforms,
including
alone,
immunotherapy‐involved
multimodal
synergistic
therapy,
imaging‐guided
detail.
Finally,
challenges
future
developments
highlighted.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(7), P. 2544 - 2582
Published: Jan. 1, 2022
Metal
complexes
are
extensively
used
for
cancer
therapy.
The
multiple
variables
available
tuning
(metal,
ligand,
and
metal-ligand
interaction)
offer
unique
opportunities
drug
design,
have
led
to
a
vast
portfolio
of
metallodrugs
that
can
display
higher
diversity
functions
mechanisms
action
with
respect
pure
organic
structures.
Clinically
approved
metallodrugs,
such
as
cisplatin,
carboplatin
oxaliplatin,
treat
many
types
play
prominent
roles
in
combination
regimens,
including
immunotherapy.
However,
generally
suffer
from
poor
pharmacokinetics,
low
levels
target
site
accumulation,
metal-mediated
off-target
reactivity
development
resistance,
which
all
limit
their
efficacy
clinical
translation.
Nanomedicine
has
arisen
powerful
tool
help
overcome
these
shortcomings.
Several
nanoformulations
already
significantly
improved
the
reduced
toxicity
(chemo-)therapeutic
drugs,
some
promising
metallodrug-containing
nanomedicines
currently
trials.
In
this
critical
review,
we
analyse
challenges
assess
advantages
limitations
metallodrug
delivery,
both
nanocarrier
metal-nano
interaction
perspective.
We
describe
latest
most
relevant
nanomedicine
formulations
developed
metal
complexes,
discuss
how
rational
coordination
chemistry
technology
assist
promoting
translation
metallodrugs.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(12), P. 5136 - 5174
Published: Jan. 1, 2022
Recent
years
have
witnessed
increasingly
rapid
advances
in
nanocarrier-based
biomedicine
aimed
at
improving
treatment
paradigms
for
cancer.
Nanogels
serve
as
multipurpose
and
constructed
vectors
formed
via
intramolecular
cross-linking
to
generate
drug
delivery
systems,
which
is
attributed
predominantly
their
satisfactory
biocompatibility,
bio-responsiveness,
high
stability,
low
toxicity.
Recently,
immunotherapy
has
experienced
unprecedented
growth
become
the
preferred
strategy
cancer
treatment,
mainly
involves
mobilisation
of
immune
system
an
enhanced
anti-tumour
immunity
tumour
microenvironment.
Despite
inspiring
success,
immunotherapeutic
strategies
are
limited
due
response
rates
immune-related
adverse
events.
Like
other
nanomedicines,
nanogels
comparably
by
lower
focal
enrichment
upon
introduction
into
organism
injection.
Because
three-dimensional
cross-linked
aqueous
materials
that
exhibit
similar
properties
natural
tissues
structurally
stable,
they
can
comfortably
cope
with
shear
forces
serum
proteins
bloodstream,
longer
circulation
life
increases
chance
nanogel
accumulation
tumour,
conferring
deep
penetration.
The
large
specific
surface
area
reduce
or
eliminate
off-target
effects
introducing
stimuli-responsive
functional
groups,
allowing
multiple
physical
chemical
modifications
purposes
improve
targeting
cell
subpopulations
organs,
increasing
bioavailability
drug,
a
events
on
therapies.
slow
release
reaching
site
facilitates
long-term
awakening
host's
system,
ultimately
achieving
therapeutic
effects.
As
effective
candidate
immunotherapy,
nanogel-based
been
widely
used.
In
this
review,
we
summarize
recent
deliver
immunomodulatory
small
molecule
drugs,
antibodies,
genes
cytokines,
target
antigen
presenting
cells,
form
vaccines,
enable
chimeric
receptor
(CAR)-T
therapy.
Future
challenges
well
expected
feasible
prospects
clinical
also
highlighted.
