Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 25, 2024

Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based

Language: Английский

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Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 21, 2024

Abstract Cell membrane‐coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within cell membrane‐derived coating, these combine the advantages of synthetic and natural membranes. This review provides comprehensive overview recent advancements in utilizing CMNPs effective drug delivery vehicles The synthesis fabrication methods are comprehensively discussed. Various techniques, such extrusion, sonication, self‐assembly, employed to coat with membranes derived from different types. membrane coating enables biocompatibility, reducing risk an immune response enhancing stability bloodstream. Moreover, functionalization strategies CMNPs, primarily chemical modification, genetic engineering, external stimuli, highlighted. presence specific surface markers on coated allows targeted cells maximizes efficacy. Preclinical studies therapy demonstrated successful various agents, chemotherapeutic drugs, nucleic acids, immunotherapeutic using CMNPs. Furthermore, article explores future directions challenges this technology while offering insights into its clinical potential.

Language: Английский

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“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria‐targeted photodynamic therapy against hypoxic tumors

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Abstract Currently three major problems seriously limit the practical application of cancer photodynamic therapy (PDT): (i) hypoxic tumor microenvironment (TME); (ii) low generation efficiency toxic reactive oxygen species (ROS) in aggregates and (iii) shallow tissue penetration depth excitation light. Very limited approaches are available for addressing all above with a single design. Herein, rational “three birds one stone” molecular nanoengineering strategy is demonstrated: nanoplatform U‐Ir@PAA‐ABS based on covalent combination lanthanide‐doped upconversion nanoparticles (UCNPs) an AIE‐active dinuclear Ir(III) complex provides concentration‐dependent type‐I photochemical process upon 980 nm irradiation by Föster resonance energy transfer (FRET). targets mitochondria has excellent phototoxicity even severe hypoxia environments irradiation, inducing dual‐mode cell death mechanism apoptosis ferroptosis. Taken together, vitro vivo results demonstrate successful improving efficacy PDT against tumors.

Language: Английский

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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: June 9, 2024

Abstract The tumor microenvironment (TME) of typical types such as triple‐negative breast cancer is featured by hypoxia and immunosuppression with abundant tumor‐associated macrophages (TAMs), which also emerge potential therapeutic targets for antitumor therapy. M1‐like macrophage‐derived exosomes (M1‐Exos) have emerged a promising candidate their tumor‐targeting macrophage‐polarization capabilities. However, the limited drug‐loading efficiency stability M1‐Exos hindered effectiveness in applications. Here, hybrid nanovesicle developed integrating AS1411 aptamer‐conjugated liposomes (AApt‐Lips), termed M1E/AALs. obtained M1E/AALs are loaded perfluorotributylamine (PFTBA) IR780, P‐I, to construct P‐I@M1E/AALs reprogramming TME alleviating engineering TAMs. P‐I@M1E/AAL‐mediated therapy enhances situ generation reactive oxygen species, repolarizes TAMs toward an phenotype, promotes infiltration T lymphocytes. synergistic based on significantly suppresses growth prolongs survival 4T1‐tumor‐bearing mice. By multiple treatment modalities, P‐I@M1E/AAL nanoplatform demonstrates approach overcoming hypoxic immunosuppressive targeted TAM enhanced photodynamic immunotherapy. This study highlights innovative TAM‐engineering platform tumors characterized TME.

Language: Английский

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Inflammation-Responsive Nanoagents for Activatable Photoacoustic Molecular Imaging and Tandem Therapies in Rheumatoid Arthritis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2231 - 2249

Published: Jan. 8, 2024

Rheumatoid arthritis (RA) severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, representing a pressing public health concern. The pathogenesis of RA includes excessive production proinflammatory cytokines harmful oxygen-derived free radicals, such as nitric oxide (NO), which constitute vital targets for precise diagnosis effective treatment RA. In this study, we introduce an advanced nanoagent that integrates microenvironment-activatable photoacoustic (PA) imaging with multitarget synergistic A highly sensitive organic probe NO-tunable energy transformation molecular geometry is developed, enables strong near-infrared absorption turn-on PA signal, active intramolecular motion could further boost conversion. coassembled inflammation-responsive prodrug to construct theranostic nanoagent, on macrophage-derived cell membrane natural tropism inflammatory sites camouflaged improve targeting ability inflamed joints. not only sensitively detect differentiate severity but also efficiently alleviate symptoms function. combination activatable probe-mediated NO scavenging on-demand activation anti-inflammatory significantly inhibits factors promotes macrophage repolarization from M1 M2 phenotype. This meticulously designed ingeniously RA-specific therapy, rendering tremendous promise intervention RA-related diseases.

Language: Английский

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Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, a novel nanoplatform, LipoHPM, designed to address these challenges, is reported. This approach employs an acid‐sensitive amine linker connect biotin‐modified hydrophilic polymer ( Biotin PEG) with new hydrophobic photosensitizer (MBA), forming OFF‐state P EG‐ M BA (PM) micelles via aggregation‐caused quenching (ACQ) These are then co‐loaded the tumor penetration enhancer hydralazine H DZ) into pH‐sensitive liposomes (Lipo HPM ). Leveraging ACQ effect, LipoHPM silent both fluorescence reactive oxygen species (ROS) generation during blood circulation but restores properties upon disassembly. Following intravenous injection tumor‐bearing mice, actively targets cells overexpressing biotin‐receptors, contributing enhanced accumulation. Upon cellular internalization, disassembles within lysosomes, releasing HDZ enhance inhibit metastasis. Concurrently, activate boost production of type‐I type‐II ROS eradication. Therefore, smart synergistically integrates near‐infrared emission, activatable imaging, robust generation, efficient anti‐metastasis activity, successfully overcoming limitations conventional photosensitizers establishing itself as promising nanoplatform potent FIG‐PDT applications.

Language: Английский

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Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Language: Английский

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12234 - 12257

Published: Jan. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Language: Английский

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Recent strategies for evoking immunogenic Pyroptosis in antitumor immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 375 - 394

Published: Jan. 9, 2024

Pyroptosis is a specific type of programmed cell death (PCD) characterized by distinct morphological changes, including swelling, membrane blebbing, DNA fragmentation, and eventual lysis. closely associated with human-related diseases, such as inflammation malignancies. Since the initial observation pyroptosis in Shigella flexneri-infected macrophages more than 20 years ago, various pyroptosis-inducing agents, ions, small molecules, biological nanomaterials, have been developed for tumor treatment. Given that can activate body's robust immune response against promote formation long-term memory treatment, its status immunogenic self-evident. Therefore, should be used powerful anti-tumor strategy. However, there still lack comprehensive summary most recent advances pyroptosis-based cancer therapy. it vital to fill this gap inspire future drug design better induce cells undergo achieve advanced effects. In review, we summarize detail triggering adequate clearance based on treatment modalities, highlight material therapeutic advantages. Besides, also provide an outlook prospects emerging field next development.

Language: Английский

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