Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(12)

Published: Feb. 19, 2022

Abstract Cutaneous wound healing, especially diabetic is a common clinical challenge. Reactive oxygen species (ROS) and bacterial infection are two major detrimental states that induce oxidative stress inflammatory responses impede angiogenesis healing. A derivative of the metabolite itaconate, 4‐octyl itaconate (4OI) has attracted increasing research interest in recent years due to its antioxidant anti‐inflammatory properties. In this study, 4OI‐modified black phosphorus (BP) nanosheets incorporated into photosensitive, multifunctional gelatin methacrylamide hydrogel produce new photothermal therapy (PTT) photodynamic (PDT) system with antibacterial properties for regeneration. Under laser irradiation, 4OI–BP‐entrapped enables rapid gelation, forming membrane on wounds, offers high PTT PDT efficacy eliminate infection. Without BP acts as carrier controls release 4OI, which it synergistically enhances activity, thus alleviating excessive ROS damage endothelial cells, promoting neovascularization, facilitating faster closure. These findings indicate provides stepwise countermeasure enhanced healing may lead novel therapeutic interventions ulcers.

Language: Английский

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Recent advances in the photothermal applications of two-dimensional nanomaterials: photothermal therapy and beyond

Journal of Materials Chemistry A, Journal Year: 2021, Volume and Issue: 9(33), P. 17569 - 17591

Published: Jan. 1, 2021

The photothermal applications of 2D nanomaterials in therapy, water evaporation, thermochemical reactions, light-driven actuators, electrodes, energy storage, wearable heaters and bacterial inhibition.

Language: Английский

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Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(5)

Published: Jan. 15, 2021

Abstract Cancer has been one of the major threats to lives human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order improve treatment efficiency drugs, an intelligent drug delivery system (DDS) considered a promising solution strategy. Due their special structure and large specific surface area, 2D materials are be good platform delivery. Black phosphorus (BP), new star family, recommended have potential construct DDS by virtue its outstanding photothermal (PTT), photodynamic (PDT), biodegradable properties. This tutorial review intended provide introduction current advances BP‐based DDSs cancer therapy, which covers topics from construction, classified types platforms, stimuli‐responsive controlled release. Moreover, applications including mono‐, bi‐, multi‐modal synergistic well research biocompatibility also discussed. Finally, status future prospects summarized.

Language: Английский

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Regulation of Osteoimmune Microenvironment and Osteogenesis by 3D‐Printed PLAG/black Phosphorus Scaffolds for Bone Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 24, 2023

The treatment of bone defects remains a significant challenge to be solved clinically. Immunomodulatory properties orthopedic biomaterials have significance in regulating osteoimmune microenvironment for osteogenesis. A lactic acid-co-glycolic acid (PLGA) scaffold incorporates black phosphorus (BP) fabricated by 3D printing technology investigate the effect BP on osteoimmunomodulation and osteogenesis site. PLGA/BP exhibits suitable biocompatibility, biodegradability, mechanical as an excellent support new formation. studies' result also demonstrate that scaffolds are able recruit stimulate macrophages M2 polarization, inhibit inflammation, promote human marrow mesenchymal stem cells (hBMSCs) proliferation differentiation, which turn promotes regeneration distal femoral defect region steroid-associated osteonecrosis (SAON) rat model. Moreover, it is screened demonstrated can osteogenic differentiation transcriptomic analysis, mineralization activating PI3K-AKT signaling pathway hBMSC cells. In this study, shown innovative extremely effective stimulating macrophage polarization strategy development used repair offered.

Language: Английский

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Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

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Multifunctional nanoparticle for cancer therapy

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Language: Английский

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Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(46), P. 54621 - 54647

Published: Nov. 12, 2021

Owing to the distinctive constituents of tumor tissue from those healthy organs, nanomedicine strategies show significant potentials in smart drug delivery. Nowadays, stimuli-responsive nanogels are playing increasingly important roles application cancer therapy because their sensitivity various internal or external physicochemical stimuli, which exhibit site-specific and markedly enhanced release. Besides, promising as carriers porous structures, good biocompatibility, large surface area, excellent capability with drugs. Taking advantage multiresponsiveness, recent years have witnessed rapid evolution stimulus-responsive monoresponsive multiresponsive systems; however, there lacks a comprehensive review summarizing these reports. In this Review, we discuss properties, synthesis, characterization nanogels. Moreover, microenvironment corresponding designing for stimuli-response nanogels, both exogenous (temperature, magnetic field, light) endogenous (pH, biomolecular, redox, ROS, pressure, hypoxia) summarized on basis advances multistimuli-responsive nanogel systems. Nanogel two-dimensional material composites performance field constructing multistimulus-responsive nanoparticles precise intelligent release integrated system multimodal diagnosis therapy. Finally, potential progresses suggestions provided further design hybrid based emerging materials.

Language: Английский

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Mussel‐Inspired Ligand Clicking and Ion Coordination on 2D Black Phosphorus for Cancer Multimodal Imaging and Therapy

Small, Journal Year: 2022, Volume and Issue: 18(26)

Published: May 26, 2022

As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in inherent instability, while it can be improved by surface modification strategies to great extent. Considering existing infirm BP NSs strategies, A mussels-inspired strong adhesive biomimetic peptide with azide groups for increase stability is synthesized. The on quickly and precisely bind targeting ligand through click chemistry, solving problem nonspecificity secondary other mussel-mimicking materials. Besides, catechol-Gd3+ coordination network further constructed magnetic resonance imaging (MRI) inducing intracellular endo/lysosome escape. fabricated BP-DOX@Gd/(DOPA)4 -PEG-TL nanoplatform exhibits enhanced antitumor abilities synergetic chemo/photothermal effects both vitro vivo.

Language: Английский

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The recent progress of inorganic‐based intelligent responsive nanoplatform for tumor theranostics

View, Journal Year: 2022, Volume and Issue: 3(6)

Published: Aug. 22, 2022

Abstract Inorganic nanoplatform exhibits great potentials in drug delivery and responsive release attributed to its inherent physicochemical properties, good biocompatibility, surface modification, easy synthesis. In this review, the recent progresses on inorganic smart bio‐responsive nanoplatforms for tumor theranostics are summarized, which could be triggered by either endogenous microenvironment (TME) or exogenous physical hopeful achieve safe, precise, high efficacy therapy. Notably, these generally dependent intelligent multifunctional design of nanocarriers, including mesoporous silica nanoparticles (MSNs), black phosphorus (BP), Prussian blue (PB), other inorganic‐based nanoparticles. Finally, perspectives challenges future translational medicine proposed.

Language: Английский

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