Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Advanced Science, Journal Year: 2021, Volume and Issue: 8(8)

Published: March 5, 2021

Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement movement, lack antibacterial function, frequent replacements. Hydrogels have been considered as good candidates for wound dressing because their flexibility biocompatibility. Nevertheless, the adhesive, mechanical, properties conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted bacterial cellulose (BC) nanofibers introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer rigid BC backbones enhance mechanical property hydrogels, realizing high tensile strength (21-51 kPa), large strain (899-1047%), ideal compressive property. Positively charged quaternary ammonium groups tethered provide long-lasting promote crawling proliferation negatively epidermis cells. Moreover, rich catechol capable adhering various surfaces, meeting adhesive demand movement areas. With above merits, demonstrate less inflammatory response faster healing speed vivo on rats. Therefore, multifunctional show stable covering, little displacement, antibacteria, fast healing, demonstrating promise dressing.

Language: Английский

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Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

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Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

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Development of Conductive Hydrogels for Fabricating Flexible Strain Sensors

Small, Journal Year: 2021, Volume and Issue: 18(5)

Published: Oct. 17, 2021

Abstract Conductive hydrogels can be prepared by incorporating various conductive materials into polymeric network hydrogels. In recent years, have been developed and applied in the field of strain sensors owing to their unique properties, such as electrical conductivity, mechanical self‐healing, anti‐freezing properties. These remarkable properties allow hydrogel‐based show excellent performance for identifying external stimuli detecting human body movement, even at subzero temperatures. This review summarizes application fabrication working different modes. Finally, a brief prospectus development future is provided.

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 341, P. 147 - 165

Published: Nov. 20, 2021

Language: Английский

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Hydrogel tapes for fault-tolerant strong wet adhesion

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Dec. 9, 2021

Fast and strong bio-adhesives are in high demand for many biomedical applications, including closing wounds surgeries, fixing implantable devices, haemostasis. However, most rely on the instant formation of irreversible covalent crosslinks to provide surface binding. Repositioning misplaced adhesives during surgical operations may cause severe secondary damage tissues. Here, we report hydrogel tapes that can form physical interactions with tissues seconds gradually bonds hours. This timescale-dependent adhesion mechanism allows robust wet be combined fault-tolerant convenient operations. Specifically, inspired by catechol chemistry discovered mussel foot proteins, develop an electrical oxidation approach controllably oxidize catecholquinone, which reacts slowly amino groups tissue surface. We demonstrate show fast reversible at initial stage ultrastrong after linkages over hours various electronic devices. Given biocompatible, easy use, bio-adhesion, anticipate they find broad clinical applications.

Language: Английский

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Multifunctional hydrogel as wound dressing for intelligent wound monitoring

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 433, P. 134625 - 134625

Published: Jan. 11, 2022

Language: Английский

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Stretchable graphene–hydrogel interfaces for wearable and implantable bioelectronics

Nature Electronics, Journal Year: 2023, Volume and Issue: 7(1), P. 51 - 65

Published: Dec. 14, 2023

Language: Английский

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