Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 13022 - 13036

Published: Aug. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Language: Английский

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Skin bioelectronics towards long-term, continuous health monitoring

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3759 - 3793

Published: Jan. 1, 2022

Skin bioelectronics are considered as an ideal platform for personalised healthcare because of their unique characteristics, such thinness, light weight, good biocompatibility, excellent mechanical robustness, and great skin conformability. Recent advances in skin-interfaced have promoted various applications precision medicine. Particularly, long-term, continuous health monitoring offer powerful analysis a broad spectrum statuses, providing route to early disease diagnosis treatment. In this review, we discuss (1) representative sensing devices, (2) material structure selection, device properties, wireless technologies towards monitoring, (3) applications: acquisition electrophysiological, biophysical, biochemical signals, comprehensive (4) rational guidelines the design future monitoring. Long-term, advanced will open unprecedented opportunities timely prevention, screening, diagnosis, treatment, demonstrating promise revolutionise traditional medical practices.

Language: Английский

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Photothermal Hydrogel Encapsulating Intelligently Bacteria-Capturing Bio-MOF for Infectious Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 19491 - 19508

Published: Nov. 2, 2022

Chronic wounds are characterized by long-term inflammation and persistent infection, which make them difficult to heal. Therefore, an urgent desire is develop a multifunctional wound dressing that can prevent infection promote healing creating favorable microenvironment. In this study, curcumin-based metal-organic framework (QCSMOF-Van), loaded with vancomycin coated quaternary ammonium salt chitosan (QCS), was prepared. Multifunctional composite hydrogels were conveniently synthesized combining methacrylic anhydride modified gelatin oxidized sodium alginate QCSMOF-Van through radical polymerization Schiff base reaction. It important note the could capture bacteria positive charges on surface of QCS. process, due synergistic effect broad-spectrum antibacterial Zn2+ vancomycin, metabolism well inhibited, efficient capturing rapid killing achieved. The precisely regulate balance M1/M2 phenotypes macrophages, thereby promoting regeneration nerves blood vessels, promotes chronic wounds. This advanced cascade management strategy for tissue highlights potential in dressings.

Language: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

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Highly efficient bacteria-infected diabetic wound healing employing a melanin-reinforced biopolymer hydrogel

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 460, P. 141852 - 141852

Published: Feb. 11, 2023

Language: Английский

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Developing natural polymers for skin wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 355 - 376

Published: Nov. 26, 2023

Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They frequently encountered various creatures, including mammals, plants, microbes. The aforementioned commonly derived from renewable sources, possess a notable level of compatibility with living organisms, limited adverse effect on environment. As result, they hold considerable significance development sustainable environmentally friendly goods. In recent times, there has advancement investigation potential uses field biomedicine, specifically relation biomaterials exhibit antibacterial antioxidant characteristics. This review provides comprehensive overview prevalent utilized biomedical domain throughout preceding two decades. this paper, we present examination components typical methods for preparation based polymers. Furthermore, summarize application polymer materials each stage skin wound repair. Finally, key findings insights into limitations current elucidate prospects their future field.

Language: Английский

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Sustained release of magnesium and zinc ions synergistically accelerates wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 88 - 101

Published: Feb. 24, 2023

Skin wounds are a major medical challenge that threaten human health. Functional hydrogel dressings demonstrate great potential to promote wound healing. In this study, magnesium (Mg) and zinc (Zn) introduced into methacrylate gelatin (GelMA) via low-temperature magnetic stirring photocuring, their effects on skin the underlying mechanisms investigated. Degradation testing confirmed GelMA/Mg/Zn released ions (Mg2+) (Zn2+) in sustained manner. The Mg2+ Zn2+ not only enhanced migration of fibroblasts (HSFs) immortalized keratinocytes (HaCats), but also promoted transformation HSFs myofibroblasts accelerated production remodeling extracellular matrix. Moreover, healing full-thickness defects rats collagen deposition, angiogenesis re-epithelialization. We identified through which healing: entry increased concentration HSFs, effectively induced differentiate by activating STAT3 signaling pathway. synergistic effect conclusion, our study provides promising strategy for regeneration.

Language: Английский

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Programmed microalgae-gel promotes chronic wound healing in diabetes

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 3, 2024

Abstract Chronic diabetic wounds are at lifelong risk of developing foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be perform variety functions, such as antibacterial activity, supply, ROS scavenging, immune regulation, suggesting its use in therapy. Under high intensity (658 nm, 0.5 W/cm 2 ), green (GHEA) with efficient photothermal conversion mediate wound surface disinfection. decreasing 0.1 photosynthetic system GHEA continuously produce oxygen, effectively resolving problems hypoxia promoting vascular regeneration. Continuous irradiation induces astaxanthin (AST) accumulation cells, resulting gradual transformation from red hue (RHEA). RHEA scavenges excess ROS, enhances expression intracellular antioxidant enzymes, directs polarization M2 macrophages by secreting AST vesicles via exosomes. The living hydrogel sterilize enhance cell proliferation migration promote neoangiogenesis, which could improve infected healing female mice.

Language: Английский

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Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(6), P. 1375 - 1413

Published: Sept. 16, 2022

Abstract Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of fiber scaffolds their various structures, as well commonly used types drugs. Then, we discuss some representative controlling by fibers, with specific emphasis on design endogenous external stimuli-responsive systems. Afterwards, summarize recent progress engineering, including soft engineering (such skin, nerve, cardiac repair) hard bone, cartilage, musculoskeletal systems), Furthermore, provide future development directions challenges facing use fibers controlled delivery, aiming insights perspectives smart platforms improve clinical therapeutic effects in Graphical abstract

Language: Английский

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