The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

---

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

---

Good Steel Used in the Blade: Well‐Tailored Type‐I Photosensitizers with Aggregation‐Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(14)

Published: May 21, 2021

Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration distinctive strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, precise nuclear targeting protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics fabricated first time. Of two synthesized AIE PSs, TTFMN demonstrated exhibit superior property stronger reactive species (ROS) generation efficiency owing introduction tetraphenylethylene smaller singlet-triplet energy gap, respectively. With aid lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k-poly(ethylene glycol)5k-succinic anhydride-modified TAT, corresponding TTFMN-loaded nanoparticles accompanied acid-triggered peculiarity can quickly accumulate tumor site, effectively generate ROS region suppress growth under white light irradiation minimized systematic toxicity. This delicate "Good Steel Used Blade" tactic maximizes efficacy offers conceptual while practical paradigm optimized treatment further translational medicine.

Language: Английский

---

Cationization to boost both type I and type II ROS generation for photodynamic therapy

Biomaterials, Journal Year: 2021, Volume and Issue: 280, P. 121255 - 121255

Published: Nov. 17, 2021

Language: Английский

---

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Aggregate, Journal Year: 2023, Volume and Issue: 4(5)

Published: May 6, 2023

Abstract Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to advantages large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared demonstrated deep penetration suitable signal‐to‐noise ratio, which allows reliable vivo imaging. Combined with other modalities, multimodal could provide multidimensional hallmarks from perspectives. In addition, phototherapy be photodynamic therapy photothermal therapy, facilitate ablation cells good biosafety effects vivo. nanoparticles fabricated some specific chemicals, drugs, siRNA, display synergistic cancers. This paper comprehensively describes current status future perspectives AIEgens, showed a potential preclinical clinical translation on theranostics cancer.

Language: Английский

---

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Language: Английский

---

Synchronously boosting type-I photodynamic and photothermal efficacies via molecular manipulation for pancreatic cancer theranostics in the NIR-II window

Biomaterials, Journal Year: 2022, Volume and Issue: 283, P. 121476 - 121476

Published: March 18, 2022

Language: Английский

---

Review on recent trends and prospects in π‐conjugated luminescent aggregates for biomedical applications

Aggregate, Journal Year: 2022, Volume and Issue: 3(5)

Published: Feb. 2, 2022

Abstract Metal‐free organic molecules with structurally diverse aggregation‐induced emission (AIE) behavior and new functional photophysical properties reveal unique structure–property relationships, especially bright luminescence, have attracted extensive attention in the past few decades. Despite tremendous progress on fluorescent development, extended π‐conjugated AIE probes their nanorange self‐assembly, coassembly, morphology, high biocompatibility, light‐harvesting capabilities enable them as potential candidates numerous translational application perspectives. In particular, a important classes of light up small molecules, supramolecules, oligomers, polymers, including nanoparticles photosensitizer emerging thermally activated delayed fluorescence, room temperature phosphorescence, switching stimuli‐responsive multifunctional properties, been boosted by rare features aggregation at condensed or solid states. This review highlights salient AIE‐based emitters, encompassing molecular design strategies, stimulating mechanistic aspects, efficacy various electronic biomedical applications, broadly covering to macromolecules polymers.

Language: Английский

---

Photodynamic and photothermal therapies for bacterial infection treatment

Smart Molecules, Journal Year: 2023, Volume and Issue: 1(1)

Published: May 16, 2023

Abstract Bacteria can cause numerous infectious diseases and has been a major threat to human humans. Although antibiotics have partially succeeded in treating bacteria, owing antibiotic abuse, the emergence of multidrug‐resistant (MDR) bacteria drastically diminished their potency. Since invention laser, combination light photosensitizers, photodynamic therapy (PDT), become an effective noninvasive treatment along with photothermal (PTT), which heat is generated by nonradiative relaxation. Antimicrobial PDT PTT are emerging as treatments for bacterial infection, particularly against MDR bacteria. This mini review covers recent progresses treatment.

Language: Английский

---

Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(46)

Published: Sept. 8, 2023

The phototoxicity of photosensitizers (PSs) pre and post photodynamic therapy (PDT), the hypoxic tumor microenvironment are two major problems limiting application PDT. While activatable PSs can successfully address PS PDT, type I generate reactive oxygen species (ROS) effectively in environment, very limited approaches available for addressing There is virtually no solution to all these issues using a single design. Herein, we propose proof-of-concept on-demand switchable photosensitizer with quenched photosensitization which could be activated only environment. Particularly, hypoxia-normoxia cycling responsive TPFN-AzoCF3 was designed demonstrate concept, further formulated into nanoparticles (NPs) DSPE-PEG-2000 as encapsulation matrix. NPs tumors ROS during PDT treatment, but remain non-toxic normal tissues, or after thus minimizing side effects improving therapeutic effect. With promising results vitro vivo this presented strategy will pave way design more minimized future.

Language: Английский

---