Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: June 25, 2024
Emerging
infectious
diseases
like
coronavirus
pneumonia
(COVID-19)
present
significant
challenges
to
global
health,
extensively
affecting
both
human
society
and
the
economy.
Extracellular
vesicles
(EVs)
have
demonstrated
remarkable
potential
as
crucial
biomedical
tools
for
COVID-19
diagnosis
treatment.
However,
due
limitations
in
performance
titer
of
natural
vesicles,
their
clinical
use
remains
limited.
Nonetheless,
EV-inspired
strategies
are
gaining
increasing
attention.
Notably,
biomimetic
inspired
by
EVs,
possess
specific
receptors
that
can
act
"Trojan
horses,"
preventing
virus
from
infecting
host
cells.
Genetic
engineering
enhance
these
enabling
them
carry
more
receptors,
significantly
specificity
absorbing
novel
coronavirus.
Additionally,
inherit
numerous
cytokine
parent
cells,
allowing
effectively
mitigate
"cytokine
storm"
adsorbing
pro-inflammatory
cytokines.
Overall,
this
strategy
offers
new
avenues
treatment
emerging
diseases.
Herein,
review
systematically
summarizes
current
applications
COVID-19.
The
status
associated
with
implementation
also
discussed.
goal
is
provide
insights
into
design
expand
application
combating
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(52)
Published: Sept. 5, 2023
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
leverage
reactive
oxygen
species
(ROS)
control
local
hyperthermia
by
photosensitizer
to
perturb
intracellular
redox
equilibrium,
inducing
DNA
damage
in
both
mitochondria
nucleus,
activating
the
cGAS‐STING
pathway,
ultimately
eliciting
antitumor
immune
responses.
However,
current
photosensitizers
are
encumbered
limitations
such
as
suboptimal
tumor
targeting,
aggregation‐caused
quenching
(ACQ),
restricted
excitation
emission
wavelengths.
Here,
this
work
designs
novel
nanoparticles
based
on
aggregation‐induced
(AIE)
(BODTPE)
for
targeted
near‐infrared
II
fluorescence
imaging
(NIR‐II
FLI)
with
enhanced
PDT/PTT
effects.
BODTPE
is
employed
a
monomer,
dibenzocyclooctyne
(DBCO)‐PEG
2k
‐amine
serving
an
end‐capping
polymer,
synthesize
BODTPE‐containing
polymer
(DBD).
Further,
through
self‐assembly,
DBD
mPEG‐DSPE
combined
form
(NP‐DBD).
Notably,
DBCO
surface
of
NP‐DBD
can
react
azide
groups
cancer
cells
pretreated
Ac
4
ManNAz
copper‐free
click
reaction.
This
innovative
formulation
led
accumulation
within
sites,
phenomenon
convincingly
demonstrated
murine
models
subjected
N
‐azidoacetylmannosamine‐tetraacylated
(Ac
ManNAz)
pretreatment.
Significantly,
exhibits
multifaceted
effect
encompassing
PDT/PTT/NIR‐II
FLI
upon
808
nm
laser
irradiation,
thereby
better
culminating
compelling
inhibition
augmented
robust
modulation.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(26)
Published: April 19, 2024
The
second
near-infrared
(NIR-II,
1000-1700
nm)
light-activated
organic
photothermal
agent
that
synchronously
enables
satisfying
NIR-II
fluorescence
imaging
is
highly
warranted
yet
rather
challenging
on
the
basis
of
overwhelming
nonradiative
decay.
Herein,
such
an
agent,
namely
TPABT-TD,
was
tactfully
designed
and
constructed
via
employing
benzo[c]thiophene
moiety
as
bulky
electron
donor/π-bridge
tailoring
peripheral
molecular
rotors.
Benefitting
from
its
high
donor-acceptor
strength
finely
modulated
intramolecular
motion,
TPABT-TD
simultaneously
exhibits
ultralong
absorption
in
region,
intense
emission
NIR-IIa
(1300-1500
region
nanoaggregates,
conversion
upon
1064
nm
laser
irradiation.
Those
intrinsic
advantages
endow
nanoparticles
with
prominent
fluorescence/photoacoustic/photothermal
trimodal
imaging-guided
therapy
against
orthotopic
4T1
breast
tumor
negligible
adverse
effect.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1168 - 1168
Published: March 6, 2024
Many
important
biological
species
have
been
identified
as
cancer
biomarkers
and
are
gradually
becoming
reliable
targets
for
early
diagnosis
late
therapeutic
evaluation
of
cancer.
However,
accurate
quantitative
detection
remains
challenging
due
to
the
complexity
systems
diversity
development.
Fluorescent
probes
extensively
utilized
identifying
substances
their
notable
benefits
being
non-invasive,
quickly
responsive,
highly
sensitive
selective,
allowing
real-time
visualization,
easily
modifiable.
This
review
critiques
fluorescent
used
detecting
imaging
over
last
five
years.
Focuses
made
on
design
strategies
small-molecule
nano-sized
probes,
construction
methods
fluorescence
sensing
platforms,
further
applications
in
multiple
biomarkers,
including
enzymes,
reactive
oxygen
species,
sulfur
microenvironments.
aims
guide
development
excellent
diagnostic
promote
broad
application
analysis
diagnosis.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Jan. 31, 2024
Abstract
Aggregation‐induced
emission
(AIE)
is
an
intriguing
photophysical
phenomenon,
where
specific
materials
exhibit
a
remarkable
surge
in
luminescence
when
brought
together
non‐ideal
solvents
or
within
solid
matrix.
Since
the
concept
of
AIE
was
first
introduced
2001,
numerous
advanced
applications
have
been
gradually
explored
across
various
domains,
including
optics,
electronics,
energy,
and
life
sciences.
Of
particular
note
growing
interest
application
systems
with
near‐infrared
(NIR)
emissive
feature
field
biomedicine,
encompassing
detection,
imaging,
therapeutic
interventions.
Notably,
bibliometric
analysis
serves
as
valuable
tool
to
provide
researchers
comprehensive
understanding
research
achievements
developmental
trends
fields,
which
crucial
for
academic
research.
Herein,
we
present
general
overview
spanning
two
decades
NIR‐AIE
development.
With
assistance
core
scientific
databases
software
tools,
conducted
systematic
annual
publications
citations,
most
influential
countries/regions,
leading
authors,
journals,
institutions,
well
hot
topics
related
NIR
forward‐looking
predictions.
Furthermore,
properties
biomedical
also
systematically
reviewed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(31), P. 12234 - 12257
Published: Jan. 1, 2024
Photodynamic
therapy
(PDT)
has
been
developed
as
a
potential
cancer
treatment
approach
owing
to
its
non-invasiveness,
spatiotemporal
control
and
limited
side
effects.
Currently,
great
efforts
have
made
improve
the
PDT
effect
in
terms
of
safety
efficiency.
In
this
review,
we
highlight
recent
advances
innovative
strategies
for
enhanced
PDT,
including
(1)
development
novel
radicals,
(2)
design
activatable
photosensitizers
based
on
TME
light,
(3)
photocatalytic
NADH
oxidation
damage
mitochondrial
electron
transport
chain.
Additionally,
new
mechanisms
are
also
presented
an
inspiration
PSs.
Finally,
discuss
current
challenges
future
prospects
clinical
practice
these
strategies.
It
is
hoped
that
review
will
provide
angle
understanding
relationship
between
intratumoural
redox
environment
mechanisms,
ideas
smart
systems.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
The
two
contradictory
entities
in
nature
often
follow
the
principle
of
unity
opposites,
leading
to
optimal
overall
performance.
Particularly,
aggregation-induced
emission
luminogens
(AIEgens)
with
donor–acceptor
(D–A)
structures
exhibit
tunable
optical
properties
and
versatile
functionalities,
offering
significant
potential
revolutionize
cancer
treatment.
However,
trapped
by
low
molar
absorptivity
(ε)
owing
distorted
configurations,
ceilings
their
photon-harvesting
capability
corresponding
phototheranostic
performance
still
fall
short.
Therefore,
a
research
paradigm
from
twisted
configuration
near-planar
structure
featuring
high
ε
is
urgently
needed
for
AIEgens
development.
Herein,
introducing
strategy
"motion
stillness"
into
highly
planar
A–D–A
skeleton,
we
successfully
developed
near-infrared
(NIR)-II
AIEgen
Y5-2BO-2BTF,
which
boasts
an
impressive
1.06
×
105
M–1
cm–1
photothermal
conversion
efficiency
(PCE)
77.8%.
modification
steric
hindrance
on
benzene
ring
acceptor
unit
aggregation-caused
quenching
counterpart
Y5-2BO,
meta-CF3-substituted
naphthyl,
leads
reversely
staggered
packing
various
intermolecular
noncovalent
conformational
locks
Y5-2BO-2BTF
("stillness").
Furthermore,
−CF3
moiety
acted
as
flexible
motion
ultralow
energy
barrier,
significantly
facilitating
process
loose
aggregates
("motion").
Accordingly,
nanoparticles
enabled
tumor
eradication
pulmonary
metastasis
inhibition
through
NIR-II
fluorescence-photoacoustic-photothermal
imaging-navigated
type
I
photodynamic-photothermal
therapy.
This
work
provides
first
evidence
that
conformation
stacking
arrangement
could
serve
novel
molecular
design
direction
AIEgens,
shedding
new
light
constructing
superior
agents
bioimaging
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(42), P. 28783 - 28794
Published: Oct. 11, 2024
Currently
used
drugs
for
glioblastoma
(GBM)
treatments
are
ineffective,
primarily
due
to
the
significant
challenges
posed
by
strong
drug
resistance,
poor
blood-brain
barrier
(BBB)
permeability,
and
lack
of
tumor
specificity.
Here,
we
report
two
cationic
fluorescent
anticancer
agents
(TriPEX-ClO
