Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(22)
Published: May 25, 2023
Abstract
The
local
application
of
drug‐loaded
bioactive
scaffold
materials
is
one
the
important
directions
to
solve
clinical
problem
osteoporotic
(OP)
bone
defects.
This
study
retains
advantages
drug
loading
and
mechanical
properties
natural
3D
scaffolds.
scaffolds
are
functionally
modified
through
chemical
self‐assembly
approaches
with
polydopamine
(PDA)
nanoparticles
parathyroid
hormone‐related
peptide‐1
(PTHrP‐1)
for
efficient
loading.
investigates
effects
novel
on
ossification,
osteoclastogenesis,
macrophage
polarization.
work
elucidates
in
regulating
osteoclastic
activity
new
formation
vitro.
Further
studies
establishment
repair
OP
defects
small
animals
conducted,
potential
porous
promote
initially
verified.
preparation
safe
economical
anti‐OP
material
provides
a
theoretical
basis
translational
applications.
Small Structures,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
The
increasing
demand
of
advanced
biomedical
materials
for
bone
repair
and
regeneration
has
spurred
significant
research
in
recent
years.
While
traditional
hydrogels
offer
promising
biocompatibility
easy
fabrication,
their
application
reconstruction
is
often
impeded
by
inadequate
structural
integrity
biological
functions.
Graphene
oxide
(GO)
emerged
as
a
transformative
additive,
renowned
its
exceptional
mechanical
chemical
properties,
well
ability
to
enhance
the
hydrogels.
In
this
study,
incorporation
GO
into
chitosan
(CS)
investigated,
achieving
bioinspired
with
enhanced
strength
stability,
which
are
crucial
supporting
regeneration.
Additionally,
self‐assembled
synthetic
peptide
nanofibers
(PNFs)
employed
facilitate
biomimetic
mineralization
hydrogels,
critical
process
effective
remodeling.
This
innovative
composite
hydrogel
not
only
achieves
but
also
exhibits
osteogenic,
pro‐angiogenic,
antioxidant
properties
essential
repair.
novel
method
takes
advantage
distinctive
GO,
PNFs,
biomass
providing
robust
material
solution
potential
significantly
advance
field
tissue
engineering.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(32), P. 6078 - 6106
Published: Jan. 1, 2022
In
recent
years,
a
variety
of
novel
materials
and
processing
technologies
have
been
developed
to
prepare
tissue
engineering
scaffolds
for
bone
defect
repair.
Among
them,
nanofibers
fabricated
via
electrospinning
technology
attracted
much
interest
owing
the
unique
feature
highly
mimicking
natural
extracellular
matrix.
particular,
many
achievements
made
in
this
field
over
past
several
years.
Therefore,
review
aims
summarize
most
advances
highlights
electrospun
regeneration
applications,
by
focusing
on
their
material
compositions
(synthetic
polymers,
composite
nanofibers,
hybrid
nanofibers),
structural
regulation
strategies
(aligned
structures,
core-shell
gradient
three-dimensional
structures),
function
(biomineralization,
osteogenesis,
vascularization,
immunomodulatory,
anti-infection),
combination
with
other
emerging
scaffold
fabrication
(3D
printing,
electrospraying,
microfluidics).
Finally,
future
challenges
nanofibrous
are
also
discussed
briefly.
It
is
anticipated
that
will
provide
useful
insights
into
development
applications.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(22)
Published: May 25, 2023
Abstract
The
local
application
of
drug‐loaded
bioactive
scaffold
materials
is
one
the
important
directions
to
solve
clinical
problem
osteoporotic
(OP)
bone
defects.
This
study
retains
advantages
drug
loading
and
mechanical
properties
natural
3D
scaffolds.
scaffolds
are
functionally
modified
through
chemical
self‐assembly
approaches
with
polydopamine
(PDA)
nanoparticles
parathyroid
hormone‐related
peptide‐1
(PTHrP‐1)
for
efficient
loading.
investigates
effects
novel
on
ossification,
osteoclastogenesis,
macrophage
polarization.
work
elucidates
in
regulating
osteoclastic
activity
new
formation
vitro.
Further
studies
establishment
repair
OP
defects
small
animals
conducted,
potential
porous
promote
initially
verified.
preparation
safe
economical
anti‐OP
material
provides
a
theoretical
basis
translational
applications.
