Advanced Therapeutics,
Journal Year:
2023,
Volume and Issue:
7(2)
Published: Oct. 10, 2023
Abstract
Type
2
diabetes
mellitus
is
a
chronic
metabolic
disease
which
can
adversely
affect
the
skeletal
system,
causing
detrimental
bone
effects
such
as
quality
deterioration,
loss
of
strength,
increased
fracture
risk,
and
impaired
healing.
One
major
mechanisms
increase
in
T2DM‐induced
oxidative
stress
results
an
imbalance
remodeling
affects
metabolism
regeneration.
Recently,
ROS‐scavenging
biomaterials
have
been
identified
type
promising
therapeutic
substance
to
alleviate
tissue
microenvironment.
The
aim
this
review
elaborate
T2DM
mediated
tissues
current
application
engineering
provides
novel
insight
into
diabetic
tissue.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
11(1), P. 12 - 36
Published: Oct. 4, 2023
With
the
increasing
and
aging
of
global
population,
there
is
a
dramatic
rise
in
demand
for
implants
or
substitutes
to
rehabilitate
bone-related
disorders
which
can
considerably
decrease
quality
life
even
endanger
lives.
Though
titanium
its
alloys
have
been
applied
as
mainstream
material
fabricate
load-bearing
bone
defect
restoration
temporary
internal
fixation
devices
fractures,
it
far
from
rare
encounter
failed
cases
clinical
practice,
particularly
with
pathological
factors
involved.
In
recent
years,
smart
stimuli-responsive
(SSR)
strategies
conducted
functionalize
improve
regeneration
conditions,
such
bacterial
infection,
chronic
inflammation,
tumor
diabetes
mellitus,
NPG Asia Materials,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: March 8, 2024
Abstract
Bone
tissue
engineering
is
pivotal
in
facilitating
bone
reconstruction
by
promoting
persistent
angiogenesis
and
osteogenesis.
Initially,
the
hot
gel
composite
hydrogel
scaffold
technique
was
employed.
However,
to
address
various
limitations,
numerous
structures
have
since
been
developed,
including
osteogenic
gellan
gels,
semi-interpenetrating
network
hydrogels,
photoinduced
crosslinking
methacrylate
supramolecular
hydrogels.
This
review
examines
mechanisms,
formation
principles,
medical
benefits
of
these
structures.
In
addition,
novel
bioengineering
techniques
regulate
human
growth
are
expected
emerge
future.
work
significantly
expedite
advancement
membranes
field
repair.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 25, 2024
Osteoporosis
(OP)
is
a
bone
disease
associated
with
increasing
age.
Currently,
the
most
common
medications
used
to
treat
OP
are
anabolic
agents,
anti-resorptive
and
other
mechanisms
of
action.
However,
many
these
have
unfavorable
adverse
effects
or
not
intended
for
long-term
use,
potentially
exerting
severe
negative
impact
on
patient’s
life
career
placing
heavy
burden
families
society.
There
an
urgent
need
find
new
drugs
that
can
replace
fewer
effects.
Quercetin
(Que)
flavonol
in
nature.
Numerous
studies
examined
therapeutic
applications
Que.
comprehensive
review
anti-osteoporotic
Que
has
yet
been
conducted.
This
aimed
describe
recent
Que,
including
its
biological,
pharmacological,
pharmacokinetic,
toxicological
properties.
The
outcomes
demonstrated
could
enhance
by
osteoblast
differentiation
activity
reducing
osteoclast
via
pathways
Wnt/β-catenin,
BMP/SMAD/RUNX2,
OPG/RANKL/RANK,
ERK/JNK,
oxidative
stress,
apoptosis,
transcription
factors.
Thus,
promising
novel
drug
treatment
OP.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 13, 2024
Abstract
Nanobodies
(Nbs),
the
smallest
antigen-binding
fragments
with
high
stability
and
affinity
derived
from
variable
domain
of
naturally
occurring
heavy-chain-only
antibodies
in
camelids,
have
been
shown
as
an
efficient
way
to
improve
specificity
tumors
for
photodynamic
therapy
(PDT).
Nonetheless,
rapid
clearance
Nbs
vivo
restricts
accumulation
retention
photosensitizer
at
tumor
site
causing
insufficient
therapeutic
outcome,
especially
large-volume
tumors.
Herein,
we
develop
conjugates,
MNB-Pyra
Nbs,
through
site-specific
conjugation
between
7D12
type
I
(morpholine-modified
nile
blue
structure
connected
pyrazolinone)
a
1:2
ratio.
The
photosensitizers
long-term
can
be
released
by
reactive
oxygen
species
cleavage
after
illumination,
accompanied
fluorescence
recovery
self-reporting
occurrence
PDT.
Ultimately,
single
dose
demonstrate
highly
effective
suppression
biosafety
models
three
rounds
This
nanobody
conjugate
provides
paradigm
design
precise
long-time
is
expected
promote
development
Polymers,
Journal Year:
2023,
Volume and Issue:
15(2), P. 416 - 416
Published: Jan. 12, 2023
Thermosensitive
chitosan/collagen
hydrogels
are
osteoconductive
and
injectable
materials.
In
this
study,
we
aimed
to
improve
these
properties
by
adjusting
the
ratio
of
nanohydroxyapatite
particles
calcium
carbonate
microcapsules
in
a
β-glycerophosphate-crosslinked
hydrogel.
Two
hydrogel
systems
with
2%
5%
were
studied,
each
which
had
varying
microcapsule
content
(i.e.,
0%,
1%,
2%,
5%).
Quercetin-incorporated
prepared.
Calcium
then
added
according
composition
studied
system.
The
hydrogels,
including
cytotoxicity
biocompatibility,
investigated
mice.
2-6
µm
size,
spherical,
rough
nanoporous
surfaces,
thus
exhibited
burst
release
impregnated
quercetin.
system
is
solid
particulate
gel
that
supports
homogeneous
distribution
three-dimensional
matrix
hydrogels.
increased
mechanical
physical
strength,
viscoelasticity,
stability
while
decreasing
their
porosity,
swelling,
degradation
rates.
microcapsules-nanohydroxyapatite
noncytotoxic
biocompatible.
can
be
tailored
particles.
1%
containing
particle-chitosan/collagen
permeability,
prolonged
profiles
quercetin,
superior
those
other
optimal
for
promoting
bone
regeneration
delivering
natural
flavonoids.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 23, 2024
Abstract
Current
treatment
of
postmenopausal
osteoporosis
(PMOP)
focuses
on
systemic
administration
medication,
neglecting
to
proactively
modulate
the
local
microenvironment
skeletal
system
for
superior
therapeutic
performance.
Eldecalcitol
(ED‐71),
a
novel
drug
treating
osteoporosis,
still
requires
research
overcome
high‐frequency
delivery
and
low‐utilization.
Here,
bone‐targeting
multishelled
nanoparticles
are
developed
step‐wise
release
ED‐71.
The
achieved
by
using
chitosan/alginate
outer
layer
as
protective
barrier
against
gastric
acid,
pectin
middle
adhesive
agent
that
improved
intestinal
penetration,
ethylene
diamine
tetraacetic
acid‐grafted
mesoporous
silica
nanomaterials
core
nanocarriers.
After
oral
administration,
ED‐71‐loaded
(ME‐ED‐71@PCA)
promotes
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
reducing
intracellular
oxidative
stress,
inhibits
osteoclast
differentiation.
ME‐ED‐71@PCA
improves
mass
in
ovariectomized‐mice
promoting
osteogenesis
inhibiting
osteoclastogenesis,
efficacy
is
more
pronounced
than
ED‐71
alone.
exhibits
satisfactory
performance
due
its
compared
providing
new
approach
re‐establish
metabolic
homeostasis
PMOP.
