ChemPhysMater, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812
Published: April 27, 2023
Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.
Language: Английский
Citations
156
Advanced Science, Journal Year: 2022, Volume and Issue: 9(12)
Published: Feb. 18, 2022
The treatment of peripheral nerve defects has always been one the most challenging clinical practices in neurosurgery. Currently, autograft is preferred modality for defects, while therapy constantly plagued by limited donor, loss donor function, formation neuroma, distortion or dislocation, and diameter mismatch. To address these issues, emerged guide conduits (NGCs) are expected to offer effective platforms repair especially those with large complex topological structures. Up now, numerous technologies developed preparing diverse NGCs, such as solvent casting, gas foaming, phase separation, freeze-drying, melt molding, electrospinning, three-dimensional (3D) printing. 3D printing shows great potential advantages because it can quickly accurately manufacture required NGCs from various natural synthetic materials. This review introduces application personalized printed precision predicts their future directions.
Language: Английский
Citations
126
Nano Energy, Journal Year: 2022, Volume and Issue: 102, P. 107707 - 107707
Published: Aug. 18, 2022
Language: Английский
Citations
100
Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 511 - 536
Published: June 27, 2023
Bioinks are formulations of biomaterials and living cells, sometimes with growth factors or other biomolecules, while extrusion bioprinting is an emerging technique to apply deposit these bioinks biomaterial solutions create three-dimensional (3D) constructs architectures mechanical/biological properties that mimic those native human tissue organs. Printed have found wide applications in engineering for repairing treating tissue/organ injuries, as well vitro modelling testing validating newly developed therapeutics vaccines prior their use humans. Successful printing subsequent rely on the formulated bioinks, including rheological, mechanical, biological properties, process. This article critically reviews latest developments bioprinting, focusing bioink synthesis characterization, influence Key issues challenges also discussed along recommendations future research.
Language: Английский
Citations
96
Advanced Science, Journal Year: 2023, Volume and Issue: 10(12)
Published: Feb. 17, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of regeneration and functional recovery is greatly affected by physical, chemical, electrical properties NGCs. In this study, conductive multiscale filled NGC (MF-NGC) consisting electrospun poly(lactide-co-caprolactone) (PCL)/collagen nanofibers as sheath, reduced graphene oxide /PCL microfibers backbone, PCL internal structure developed. The printed MF-NGCs presented good permeability, mechanical stability, conductivity, which further promoted elongation growth Schwann cells neurite outgrowth PC12 neuronal cells. Animal studies using rat sciatic injury model reveal that promote neovascularization M2 transition through rapid recruitment vascular macrophages. Histological assessments regenerated nerves confirm significantly enhance regeneration, indicated improved axon myelination, muscle weight increase, function index. This study demonstrates feasibility 3D-printed with hierarchically oriented fibers can regeneration.
Language: Английский
Citations
82
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(13)
Published: April 9, 2022
Abstract Peripheral nerve regeneration and functional recovery is a major challenge in clinical practice. Nerve conduit an effective treatment for peripheral repair, but the traditional hollow not satisfactory repair due to limitation of cell migration nutrient transport. Herein, double cross‐linked hydrogels with injectable, self‐healing, conductive properties are synthesized by Schiff base reaction between polyaniline‐modified carboxymethyl chitosan aldehyde‐modified Pluronic F‐127 (F127‐CHO), hydrophobic interaction F127‐CHO. The hydrogel injected into cavity prepared electrodeposition. inner outer formed whole through obtain double‐layer composite conduit. neural loaded 7,8‐dihydroxyflavone (DHF) has excellent degradability, biocompatibility, antioxidant activity, Schwann proliferation activity. In rat sciatic defect model, significantly promotes compared Surprisingly, ability double‐layered DHF comparable that autologous transplantation. Therefore, this multifunctional great potential repairing.
Language: Английский
Citations
78
Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 194 - 215
Published: March 4, 2023
Over the years, electroconductive hydrogels (ECHs) have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral injury (PNI) with diabetes, given their favorable mechanical electrical properties identical to endogenous tissue. Nevertheless, PNI causes loss of inflammatory pain, especially in diabetic patients. It has established that bone marrow stem cells-derived exosomes (BMSCs-Exos) analgesic, anti-inflammatory tissue properties. Herein, we designed an ECH loaded BMSCs-Exos (ECH-Exos) dressing treat achieve functional recovery pain relief. Given its potent adhesive self-healing properties, this laminar is convenient treatment damaged fibers by automatically wrapping around them form a size-matched tube-like structure, avoiding cumbersome implantation process. Our vitro studies showed ECH-Exos could facilitate attachment migration Schwann cells. Meanwhile, Exos system modulate M2 macrophage polarization via NF-κB pathway, thereby attenuating PNI. Additionally, enhanced myelinated axonal MEK/ERK pathway vivo, consequently ameliorating muscle denervation atrophy further promoting restoration. findings suggest huge prospects regeneration, restoration relief patients
Language: Английский
Citations
51
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)
Published: May 15, 2024
Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes limited by the lack of controllable drug delivery available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)-triggered electrical stimulation (ES) release repairing injury proposed. The inner layer is barium titanate nanoparticles (BTNPs)-doped polyvinylidene fluoride-trifluoroethylene [BTNPs/P(VDF-TrFE)] electrospinning improved piezoelectricity orientation. outer side thermoresponsive poly(N-isopropylacrylamide) hybrid bioactive encapsulation. Such can not only induce neuronal-oriented extension promote neurite outgrowth US-triggered wireless ES, but also realize growth factor shrinkage under heating. Thus, NGC positively accelerate functional recovery axonal regeneration rat models long sciatic defects. It believed that proposed US-responsive will find important applications in clinic neural tissue engineering.
Language: Английский
Citations
50
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(32)
Published: May 19, 2023
Abstract Trauma often results in peripheral nerve injuries (PNIs). These are particularly challenging therapeutically because of variable diameters, slow axonal regeneration, infection severed ends, fragility the tissue, and intricacy surgical intervention. Surgical suturing is likely to cause additional damage nerves. Therefore, an ideal scaffold should possess good biocompatibility, diameter adaptability, a stable biological interface for seamless biointegration with tissues. Inspired by curl Mimosa pudica , this study aimed design develop diameter‐adaptable, suture‐free, stimulated curling bioadhesive tape (SCT) hydrogel repairing PNI. The fabricated from chitosan acrylic acid‐N‐hydroxysuccinimide lipid via gradient crosslinking using glutaraldehyde. It closely matches nerves different individuals regions, thereby providing bionic regeneration. In addition, rapidly absorbs tissue fluid surface achieving durable wet‐interface adhesion. Furthermore, chitosan‐based SCT loaded insulin‐like growth factor‐I effectively promotes regeneration excellent bioactivity. This procedure injury repair simple reduces difficulty duration surgery, advancing adaptive biointerfaces reliable materials repair.
Language: Английский
Citations
47
Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(2)
Published: Feb. 1, 2025
The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral injury (PNI). Flexible conductive materials with mechanical properties similar to those biological tissues have been shown better long-term biointegration functionality than rigid materials. In this study, liquid metal (LM)-based polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined exogenous ES repair PNI. PGPL membranes had good hydrophilicity, degradability, properties, its conductivity reached 0.66 ± 0.02 S/m. vitro studies showed that the (2 Hz, 100 mV/cm, 30 min/d) could significantly increase expression neuromarkers a pro-neural differentiation effect. vivo demonstrated NGCs in 200 mV/mm, effectively promote morphological reconstruction functional recovery sciatic rats. At 3 months post-surgery, restored conduction velocity 73.85% 5.45% normal value. LM-based prepared study long defects, which may further expand application LM field tissue engineering.
Language: Английский
Citations
2