ChemPhysMater, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(3), P. 713 - 726
Published: Jan. 29, 2024
Language: Английский
Citations
11
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(2), P. 1095 - 1114
Published: Jan. 25, 2024
Peripheral nerve injury poses a threat to the mobility and sensitivity of nerve, thereby leading permanent function loss due low regenerative capacity mature neurons. To date, most widely clinically applied approach bridging injuries is autologous grafting, which faces challenges such as donor site morbidity, shortages, necessity second surgery. An effective therapeutic strategy urgently needed worldwide overcome current limitations. Herein, magnetic guidance conduit (NGC) based on biocompatible biodegradable poly(3-hydroxybutyrate) (PHB) 8 wt % magnetite nanoparticles modified by citric acid (Fe3O4–CA) was fabricated electrospinning. The crystalline structure NGCs studied X-ray diffraction, indicated an enlarged β-phase PHB in composite compared pure conduit. Tensile tests revealed greater ductility PHB/Fe3O4–CA: has Young's modulus 221 ± 52 MPa elongation at break 28.6 2.9%, comparable clinical materials. Saturation magnetization (σs) Fe3O4–CA PHB/Fe3O4–CA 61.88 0.29 7.44 0.07 emu/g, respectively. water contact angle lower PHB, while surface free energy (σ) significantly higher, attributed higher roughness amorphous phase well possible interface interactions. In vitro, conduits supported proliferation rat mesenchymal stem cells (rMSCs) SH-SY5Y low-frequency field (0.67 Hz, 68 mT). vivo, were used bridge damaged sciatic nerves rats; did not cause acute inflammation performed barrier function, promotes regeneration. Thus, these are promising implants for regeneration peripheral nerves.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 12, 2024
Abstract Peripheral nerve injury often leads to the loss of neurological functions due slow regeneration rate and inefficient functional reconstruction. Current clinical treatments using guidance conduits (NGCs) still face challenges in providing a biomimetic microenvironment promote repair. Herein, decellularized extracellular matrix (dECM) is obtained from porcine Achilles tendon crosslinked with 3‐amino‐4‐methoxybenzoic acid grafted gelatin (PAMB‐G) obtain conductive hydrogels. Then, novel conduit developed by assembling poly(vinyl alcohol) (PVA) ECM@PAMB‐G hydrogel. This bioengineered ECM@PAMB‐G/PVA demonstrated excellent cytocompatibility, electrical conductivity, mechanical properties, biodegradability. In vitro experiments confirmed that hydrogel significantly promotes proliferation migration PC12 cells primary Schwann cells, as well growth dorsal root ganglion (DRG) axons. Furthermore, vivo studies rat sciatic model exhibited improvements axonal regeneration, cell migration, myelin sheath formation, recovery mediated conduit. work demonstrates synergistic effects cues enhancing peripheral regeneration. The shows potential an alternative autografts for supporting
Language: Английский
Citations
10
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101064 - 101064
Published: April 18, 2024
Autologous nerve transplantation (ANT) is currently considered the gold standard for treating long-distance peripheral defects. However, several challenges associated with ANT, such as limited availability of donors, donor site injury, mismatched diameters, and local neuroma formation, remain unresolved. To address these issues comprehensively, we have developed porous poly(lactic-
Language: Английский
Citations
10
ChemPhysMater, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1