Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements DOI
Zheng Chen, Maoyu Liu, Ningyu Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 3244 - 3273

Published: Feb. 29, 2024

Camptothecin (CPT) is a potent anti-cancer agent targeting topoisomerase I (TOP1). However, CPT has poor pharmacokinetic properties, causes toxicities, and leads to drug resistance, which limit its clinical use. In this paper, review the current state of research. We first briefly explain CPT's TOP1 inhibition mechanism key hurdles in development. Then we examine strategies overcome limitations through structural modifications advanced delivery systems. Though alone seem insufficient fully enhance therapeutic potential, structure-activity relationship analysis provides insights guide optimization analogs. comparison, systems integrating controlled release, imaging capabilities, combination therapies via stimulus-responsive linkers moieties show great promise for improving pharmacological profile. Looking forward, multifaceted approaches combining selective derivatives with systems, informed by emerging biological insights, hold unleashing potential.

Language: Английский

Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes DOI
Wei Pan, Muhammad Rafiq,

Waqas Haider

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907

Published: May 12, 2024

Language: Английский

Citations

33
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

31
Magnetic-field-induced activation of S-scheme heterojunction with core–shell structure for boosted photothermal-assisted photocatalytic H2 production DOI
Pengyu Hao,

Pengnian Shan,

Jialin Lu

et al.

Fuel, Journal Year: 2024, Volume and Issue: 373, P. 132394 - 132394

Published: July 2, 2024

Language: Английский

Citations

24
Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy DOI Creative Commons

Wenli Ma,

Yanyang Wang,

Yilin Xue

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(11), P. 4019 - 4030

Published: Jan. 1, 2024

This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .

Language: Английский

Citations

20
Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging DOI
Wenjin Wang,

Zhuo-Yang Xin,

Xuxian Su

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

Citations

6
A Versatile 980 nm Absorbing Aggregation‐Induced Emission Luminogen for NIR‐II Imaging‐Guided Synergistic Photo‐Immunotherapy Against Advanced Pancreatic Cancer DOI
Miao Wang, Dingyuan Yan, Meng Wang

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(36)

Published: June 24, 2022

Abstract To address urgent tasks in the treatment of advanced deep‐seated tumors, a 980 nm absorbing agent with aggregation‐induced emission tendency, namely TPE‐BT‐BBTD, which simultaneously possesses longest absorption wavelength among all reported AIE molecules is developed. The functionality deep near‐infrared‐II fluorescence imaging (NIR‐II FLI) and outstanding photothermal performance well‐tailored for pancreatic cancer treatment. With covalent attachment programmed death‐ligand 1 (αPD‐L1) antibody, αPD‐L1@TPE‐BT‐BBTD nanoparticles show precise tumor targeting excellent immunosuppression reversal ability. Following local therapy, immunogenic vaccination induced to trigger infiltration cytotoxic T lymphocytes (CTLs) tumors. decreased FoxP3 + Treg cells M2‐like macrophages that are reversed by αPD‐L1, CTLs activity further enhanced more production granzyme B (GrB), much accurately leads apoptosis effectively suppressed spontaneous metastases. Overall, based NIR‐II FLI‐mediated photo‐immunotherapy able significantly improve control primary metastasis

Language: Английский

Citations

51
Cucurbit[8]uril-mediated multi-color fluorescence system for time-dependent information encryption DOI

Biyan Lin,

Qian Wang, Zhen Qi

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(4), P. 1111 - 1119

Published: March 6, 2023

Language: Английский

Citations

39
All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo DOI
Ke Li, Kun Xu, Shaopeng Liu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20218 - 20236

Published: Oct. 15, 2023

Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the effect at low temperatures to selectively eliminate tumor cells, while safeguarding normal tissues, minimizing thermal damage, and enhancing treatment safety. First we evaluated transcriptome of cells gene level following low-temperature observed significant enrichment genes involved in cell cycle heat response-related signaling pathways. To address this challenge, have developed an engineering multifunctional nanoplatform offered all-in-one strategy for efficient sensitization PTT. Specifically, utilized MoS2 nanoparticles as core generate temperature (40–48 °C). The was coated with DPA load CPT-11 Fe2+ further modified PEG iRGD enhance specificity (MoS2/Fe@CPT-11-PEG-iRGD). Laser- acid-triggered release can significantly increase intracellular H2O2 content, cooperate ions lipid ROS activate ferroptosis. Furthermore, induced arrest temperature-sensitive S-phase, increased levels contributed degradation HSPs protein expression. This synergistic approach could effectively induce death by sensitized PTT combination ferroptosis chemotherapy. Our also maximize eradication prolong survival time tumor-bearing mice vivo. will provide more possibilities clinical applications potential avenues development multiple treatments.

Language: Английский

Citations

37
The One‐Stop Integrated Nanoagent Based on Photothermal Therapy for Deep Infection Healing and Inflammation Inhibition DOI
Wentao Wang,

Yumeng Gao,

Wang Xu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 20, 2023

Abstract Chronic wounds caused by bacterial infections are a major challenge in medical fields. The hypoxia condition extremely induces reactive oxygen species (ROS) generation and upregulates the expression of hypoxia‐inducible factor, both which can increase pro‐inflammatory M1 subtype macrophages production while reducing anti‐inflammatory M2 macrophages. Besides, bacteria‐formed biofilms hinder penetration therapeutic agents. Encouraged natural motors automatically executing tasks, hypothesized that supplying sufficient (O 2 ) would simultaneously drive agent movement, rescue hypoxic microenvironment, disrupt vicious cycle inflammation. Here, small organic molecule‐based nanoparticles (2TT‐mC6B@Cu 5.4 O NPs) possess high photothermal conversion efficiency enzymatic activities developed, including superoxide dismutase‐, catalase‐, glutathione peroxidase‐like activity. 2TT‐mC6B@Cu NPs exhibit superior ROS‐scavenging abilities synergistically relieve inflammation, alleviate conditions, promote their deep chronic wound tissues. Transcriptome analysis further demonstrates 2TT‐[email protected] inhibit biological inside bacteria. Furthermore, vivo experiments prove NPs‐based hyperthermia effectively eliminate bacteria to healing.

Language: Английский

Citations

37
NIR‐II Perylene Monoimide‐Based Photothermal Agent with Strengthened Donor–Acceptor Conjugation for Deep Orthotopic Glioblastoma Phototheranostics DOI
Jun Guan, Chang Liu, Chendong Ji

et al.

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 12, 2023

Abstract Extensive efforts have been devoted to the design of organic photothermal agents (PTAs) that absorb in second near‐infrared (NIR‐II) bio‐window, which can provide deeper tissue penetration is significant for phototheranostics lethal brain tumors. Herein, first example NIR‐II‐absorbing small molecule (N1) derived from perylene monoamide (PMI) and its bio‐application after nano‐encapsulation N1 function as a nano‐agent deep orthotopic glioblastoma (GBM) reported. By adopting dual modification strategy introducing donor‐acceptor unit extending π‐conjugation, obtained 1000–1400 nm region exhibit high conversation due apparent intramolecular charge transfer (ICT). A choline analogue, 2‐methacryloyloxyethyl phosphorylcholine, capable interacting specifically with receptors on surface blood‐brain barrier (BBB), used fabricate amphiphilic copolymer N1. The nanoparticles demonstrate efficient BBB‐crossing receptor‐mediated transcytosis well nanoparticle size approximately 26 nm. prepared excellent photoacoustic imaging growth inhibition GBM. current study demonstrates enormous potential PMI‐based NIR‐II PTAs provides an phototheranostic paradigm

Language: Английский

Citations

27