Facile Synthesis of Fe‐Based Metal‐Quinone Networks for Mutually Enhanced Mild Photothermal Therapy and Ferroptosis DOI

Zhendong Liu,

Sainan Liu,

Bin Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Mild photothermal therapy (MPTT) has emerged as a promising therapeutic modality for attenuating thermal damage to the normal tissues surrounding tumors, while heat-induced upregulation of heat shock proteins (HSPs) greatly compromises curative efficacy MPTT by increasing cellular thermo-tolerance. Ferroptosis been identified suppress overexpression HSPs accumulation lipid peroxides and reactive oxygen species (ROS), but is restricted overexpressed glutathione (GSH) in tumor microenvironment undesirable ROS generation efficiency. Herein, synergistic strategy based on mutual enhancement ferroptosis proposed cleaving recover cell sensitivity. A facile method fabricating series Fe-based metal-quinone networks (MQNs) coordinated assembly representative FTP MQNs possess high conversion efficiency (69.3 %). Upon 808 nm laser irradiation, not only trigger effective induce apoptosis more significantly, potentiate Fenton reaction marked GSH consumption boost ferroptosis, reinforced effect turn can alleviate resistance declining HSP70 defense reducing ATP levels. This study provides valuable rationale constructing large library achieving ferroptosis.

Language: Английский

Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade DOI Creative Commons
Xiaolin Liu, Xiao Liu, Xiaonan Luo

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 7, 2025

Language: Английский

Citations

2
Enhancing Tumor Targeted Therapy: The Role of iRGD Peptide in Advanced Drug Delivery Systems DOI Open Access
Dragana Nikitovic,

Ekaterina V. Kukovyakina,

Aikaterini Berdiaki

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3768 - 3768

Published: Nov. 8, 2024

Chemotherapy remains the primary therapeutic approach in treating cancer. The tumor microenvironment (TME) is complex network surrounding cells, comprising various cell types, such as immune fibroblasts, and endothelial well ECM components, blood vessels, signaling molecules. often stiff dense of TME interacts dynamically with influencing cancer growth, response, metastasis, resistance to therapy. effectiveness treatment solid tumors frequently reduced due poor penetration drug, which leads attaining concentrations below levels at site. Cell-penetrating peptides (CPPs) present a promising that improves internalization agents. CPPs, are short amino acid sequences, exhibit high ability pass membranes, enabling them deliver drugs efficiently minimal toxicity. Specifically, iRGD peptide, member notable for its capacity deeply penetrate tissues by binding simultaneously integrins ανβ3/ανβ5 neuropilin receptors. Indeed, characteristically expressed allows peptide home onto cells. Notably, respective dual-receptor targeting mechanism considerably increases permeability vessels tumors, an efficient delivery co-administered or nanoparticles into mass. Therefore, facilitates deeper drug efficacy therapies. Distinctively, we will focus on action, systems their application, deliberate future perspectives developing iRGD-conjugated therapeutics. In summary, this review discusses potential overcoming barriers maximize efficiency while minimizing side effects.

Language: Английский

Citations

9
Carbon dot decorated covalent organic framework for mild NIR-II photothermal and heterojunction amplified sonodynamic and chemodynamic therapy DOI
Yanqun Pan,

Lingling Fang,

S.H. Gu

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 119987 - 119987

Published: Jan. 1, 2025

Language: Английский

Citations

1
MXene-based mild potothermal therapy synergizes STING activation to enhance the efficacy of cancer vaccines post-cryoablation DOI
Fu-ming Wang, Xiaodong Zhu, Qianwen Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159311 - 159311

Published: Jan. 6, 2025

Language: Английский

Citations

1
“Cicada Out of the Shell” Deep Penetration and Blockage of the HSP90 Pathway by ROS‐Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy DOI Creative Commons

Fashun Li,

Jianqin Yan, Wei Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)

Published: April 22, 2024

Abstract Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer clinical trials. However, free small‐molecule drugs most drug vehicles have a low delivery efficiency deep into the tumor owing to poor hypoxic conditions at site. In this study, objective is use reactive oxygen species (ROS)‐responsive supramolecular gels co‐loaded with photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS 4 ) functionalized tetrahedral DNA (TGSAs) (G@P/TGSAs) enhance tissue cell block HSP90 pathway chemo‐ photodynamic (PDT) ‐ photothermal (PTT) trimodal therapy. The injected situ release ZnPCS TGSAs under high ROS concentrations originating from both PDT. penetrate deeply tissues augment by inhibiting pathway. Proteomics show that HSP‐related proteins molecular chaperones inhibited/activated, Simultaneously, TGSA‐regulated apoptotic activated. vivo study demonstrates efficient excellent (45% growth inhibition).

Language: Английский

Citations

8
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment DOI
Yutang Li, Yandong Wang, Zhao Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

Citations

7
Multifunctional ZnO@DOX/ICG-LMHP Nanoparticles for Synergistic Multimodal Antitumor Activity DOI Creative Commons
Zhuoyue Li, Jingru Wang, Junwei Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(2), P. 35 - 35

Published: Jan. 30, 2024

Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive loading the chemotherapy agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG), biocompatible low-molecular-weight heparin (LMHP) gatekeepers photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release ICG DOX. simultaneously produced oxygen (O2) reactive species (ROS) photodynamic therapy (PDT). The released under laser irradiation ROS PDT raised tumor temperature (PTT). DOX directly caused cell death chemotherapy. Both also induced immunogenic (ICD) immunotherapy. in vivo vitro results presented superior inhibition progression, metastasis recurrence. Therefore, this study could provide an efficient approach designing multifunctional therapy.

Language: Английский

Citations

6
Ternary heterostructure-driven photoinduced electron-hole separation enhanced oxidative stress for triple-negative breast cancer therapy DOI Creative Commons
Shuqing Dong, Yuqi Huang,

Hanrong Yan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 12, 2024

Abstract Zinc oxide nanoparticles (ZnO NPs) stand as among the most significant metal in trigger formation of reactive oxygen species (ROS) and induce apoptosis. Nevertheless, utilization ZnO NPs has been limited by shallowness short-wavelength light constrained production ROS. To overcome these limitations, a strategy involves achieving red shift towards near-infrared (NIR) spectrum, promoting separation restraining recombination electron-hole (e − -h + ) pairs. Herein, hybrid plasmonic system Au@ZnO (AZ) with graphene quantum dots (GQDs) doping (AZG) nano heterostructures is rationally designed for optimal NIR-driven cancer treatment. Significantly, multifold increase ROS generation can be achieved through following creative initiatives: (i) Au nanorods expands photocatalytic capabilities AZG into NIR domain, offering foundation NIR-induced clinical utilization; (ii) elaborate design mesoporous core-shell AZ structures facilitates redistribution pairs; (iii) incorporation GQDs structure could efficiently restrain e (iv) Modification hyaluronic acid (HA) enhance CD44 receptor mediated targeted triple-negative breast (TNBC). In addition, introduced NRs present catalysts enhancing photothermal therapy (PTT), effectively inducing apoptosis tumor cells. The resulting HA-modified (AZGH) exhibits efficient hot electron injection separation, affording unparalleled convenience enabling PDT treanment. As result, our well-designed AZGH photosensitizers exhibit excellent efficacy.

Language: Английский

Citations

6
Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐senolytics DOI Creative Commons
Hairui Zhang, Xiaoling Xu, Xin Shou

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 26, 2024

Cellular senescence is a significant risk factor for aging and age-related diseases (ARD). The canonical senolytics Dasatinib Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses challenge achieving optimal outcomes. Despite recent occurrence nanomaterial-based approaches targeting SnCs, limited therapeutic effects, potential toxicity still remain major concern. Herein, "double locks-like" nanoplatform developed that integrated Galactan coating mesoporous polydopamine to encase senolytic drug DQ. By this way, DQ only released SnCs are featured with higher levels β-galactosidase (β-gal) low PH. Additionally, nanoparticles equipped 2,2,6,6-Tetramethylpiperidine-1-oxyl (Tempo) gain enhanced photothermal converting potential. Consequently, synthesized nanosenolytics demonstrate remarkable specificity efficacy eradicating accordingly reverse pulmonary fibrosis mice without affecting normal tissues. Upon exposure near-infrared (NIR) light, efficiently remove tumor inducted by chemotherapy, thereby hindering outgrowth metastasis or breast cancer. Collectively, present study develops an "On/Off" switchable response produces more safe, efficient, feasible way delay alleviate age-associated diseases.

Language: Английский

Citations

6
Self-Delivery Nanomedicines Reverse Thermal Resistance to Enhance Tumor Mild-Temperature Photothermal Therapy DOI
Jinmei Lai,

Qun‐Ying Shi,

Yongqi Xie

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(3), P. 1526 - 1536

Published: Feb. 21, 2024

Tumoral thermal defense mechanisms considerably attenuate the therapeutic outcomes of mild-temperature photothermal therapy (PTT). Thus, developing a simple, efficient, and universal strategy to sensitize PTT is desirable. Herein, we report self-delivery nanomedicines ACy NPs comprising near-infrared (NIR) agent (Cypate), mitochondrial oxidative phosphorylation inhibitor (ATO), distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE–PEG2000), which have high drug-loading efficiency that can reverse tumoral resistance, thereby increasing efficacy. achieved targeted tumor accumulation performed NIR fluorescence imaging capability in vivo guide for optimized outcomes. The released ATO reduced intracellular ATP levels downregulate multiple heat shock proteins (including HSP70 HSP90) before PTT, reversed resistance cells, contributing excellent results vitro vivo. Therefore, this study provides biosafe, advanced, protein-blocking PTT.

Language: Английский

Citations

4