Light from Afield: Fast, High-Resolution, and Layer-Free Deep Vat 3D Printing DOI Creative Commons
Parth Chansoria, Riccardo Rizzo, Dominic Rütsche

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(14), P. 8787 - 8822

Published: July 5, 2024

Harnessing light for cross-linking of photoresponsive materials has revolutionized the field 3D printing. A wide variety techniques leveraging broad-spectrum shaping have been introduced as a way to achieve fast and high-resolution printing, with applications ranging from simple prototypes biomimetic engineered tissues regenerative medicine. Conventional light-based printing use material in layer-by-layer fashion produce complex parts. Only recently, new emerged which deploy multidirection, tomographic, light-sheet or filamented image projections deep into volume resin-filled vat photoinitiation cross-linking. These Deep Vat (DVP) approaches alleviate need layer-wise enable unprecedented fabrication speeds (within few seconds) high resolution (>10 μm). Here, we elucidate physics chemistry these processes, their commonalities differences, well emerging biomedical non-biomedical fields. Importantly, highlight limitations, future scope research that will improve scalability applicability DVP engineering medicine applications.

Language: Английский

Holographic tomographic volumetric additive manufacturing DOI Creative Commons
Maria Isabel Álvarez-Castaño, Andreas Erik Gejl Madsen, Jorge Madrid‐Wolff

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 11, 2025

Language: Английский

Citations

2
Stiffness control in dual color tomographic volumetric 3D printing DOI Creative Commons
Bin Wang, Einstom Engay, P. Stubbe

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 18, 2022

Abstract Tomographic volumetric printing (TVP) physically reverses tomography to offer fast and auxiliary-free 3D printing. Here we show that wavelength-sensitive photoresins can be cured using visible ( $$\bar{\lambda }=455$$ λ ¯ = 455 nm) UV }=365$$ 365 sources simultaneously in a TVP setup generate internal mechanical property gradients with high precision. We develop solutions of mixed acrylate epoxy monomers utilize the orthogonal chemistry between free radical cationic polymerization realize fully stiffness control. The radial resolution control is 300 µm or better an average modulus gradient 5 MPa/µm achieved. further reactive transport inhibitors defines workpiece’s shape limits achievable contrast range from 127 MPa 201 according standard tensile tests after post-processing. Our result presents strategy for controlling material spatially light-based additive manufacturing.

Language: Английский

Citations

49
Spatial‐Selective Volumetric 4D Printing and Single‐Photon Grafting of Biomolecules within Centimeter‐Scale Hydrogels via Tomographic Manufacturing DOI Creative Commons
Marc Falandt, Paulina Núñez Bernal, Oksana Y. Dudaryeva

et al.

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(15)

Published: May 23, 2023

Conventional additive manufacturing and biofabrication techniques are unable to edit the chemicophysical properties of printed object postprinting. Herein, a new approach is presented, leveraging light-based volumetric printing as tool spatially pattern any biomolecule interest in custom-designed geometries even across large, centimeter-scale hydrogels. As biomaterial platform, gelatin norbornene resin developed with tunable mechanical suitable for tissue engineering applications. The can be volumetrically within seconds at high resolution (23.68 ± 10.75 μm). Thiol-ene click chemistry allows on-demand photografting thiolated compounds postprinting, from small large (bio)molecules (e.g., fluorescent dyes or growth factors). These molecules covalently attached into structures using light projections, forming 3D spatiotemporal control ≈50 μm resolution. proof concept, vascular endothelial factor locally photografted bioprinted construct demonstrated region-dependent enhanced adhesion network formation cells. This technology paves way toward precise biofunctionalization modification chemical composition (bio)printed constructs better guide cell behavior, build bioactive cue gradients. Moreover, it opens future possibilities 4D mimic dynamic changes morphogen presentation natively experienced biological tissues.

Language: Английский

Citations

38
A review of materials used in tomographic volumetric additive manufacturing DOI Creative Commons
Jorge Madrid‐Wolff, Joseph Toombs, Riccardo Rizzo

et al.

MRS Communications, Journal Year: 2023, Volume and Issue: 13(5), P. 764 - 785

Published: Aug. 29, 2023

Volumetric additive manufacturing is a novel fabrication method allowing rapid, freeform, layer-less 3D printing. Analogous to computer tomography (CT), the projects dynamic light patterns into rotating vat of photosensitive resin. These build up three-dimensional energy dose within resin, solidifying volume desired object seconds. Departing from established sequential methods like stereolithography or digital printing, volumetric offers new opportunities for materials that can be used include viscous acrylates and elastomers, epoxies (and orthogonal epoxy-acrylate formulations with spatially controlled stiffness) formulations, tunable stiffness thiol-enes shape memory foams, polymer derived ceramics, silica-nanocomposite based glass, gelatin-based hydrogels cell-laden biofabrication. Here we review these materials, highlight challenges adapt them manufacturing, discuss perspectives they present.

Language: Английский

Citations

32
Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing DOI Creative Commons
Lucía Rodríguez‐Pombo, Laura Martínez-Castro, Xiaoyan Xu

et al.

International Journal of Pharmaceutics X, Journal Year: 2023, Volume and Issue: 5, P. 100166 - 100166

Published: Feb. 8, 2023

3D printing is driving a shift in patient care away from generalised model and towards personalised treatments. To complement fast-paced clinical environments, technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric an emerging technology that affords such speeds, being capable of producing entire objects within seconds. In this study, the first time, rotatory volumetric was used simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as drug, poly(ethylene glycol) diacrylate (PEGDA) 575 700 photoreactive monomers, water PEG 300 non-reactive diluents, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator were investigated. Two printlets successfully 12 32 s exhibited sustained drug release profiles. These results support use rotary efficient effective manufacturing various medicines at same time. With speed precision it affords, has potential become one most promising alternative pharmaceutical industry.

Language: Английский

Citations

27
3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space DOI Creative Commons
Angelique Van Ombergen, Franziska Chalupa‐Gantner, Parth Chansoria

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: June 23, 2023

Abstract 3D bioprinting has developed tremendously in the last couple of years and enables fabrication simple, as well complex, tissue models. The international space agencies have recognized unique opportunities these technologies for manufacturing cell models basic research space, particular investigating effects microgravity cosmic radiation on different types human tissues. In addition, is capable producing clinically applicable grafts, its implementation therefore can support autonomous medical treatment options astronauts future long term far‐distant missions. article discusses but also challenges operating bioprinters under conditions, mainly microgravity. While some process steps, most which involving handling liquids, are challenging microgravity, this environment help overcome problems such sedimentation low viscous bioinks. Hopefully, publication will motivate more researchers to engage topic, with publicly available becoming at International Space Station (ISS) imminent future.

Language: Английский

Citations

27
Deconvolution volumetric additive manufacturing DOI Creative Commons
Antony Orth, Daniel Webber, Yujie Zhang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 21, 2023

Volumetric additive manufacturing techniques are a promising pathway to ultra-rapid light-based 3D fabrication. Their widespread adoption, however, demands significant improvement in print fidelity. Currently, volumetric prints suffer from systematic undercuring of fine features, making it impossible objects containing wide range feature sizes, precluding effective adoption many applications. Here, we uncover the reason for this limitation: light dose spread resin due chemical diffusion and optical blurring, which becomes features ⪅0.5 mm. We develop model that quantitatively predicts variation time with size demonstrate deconvolution method correct error. This enables previously beyond capabilities manufacturing, such as complex gyroid structure variable thickness fine-toothed gear. These results position mature printing method, all but eliminating gap industry-standard

Language: Английский

Citations

26
Recent Progress of the Vat Photopolymerization Technique in Tissue Engineering: A Brief Review of Mechanisms, Methods, Materials, and Applications DOI Open Access
Ying Li, Xueqin Zhang, Xin Zhang

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(19), P. 3940 - 3940

Published: Sept. 29, 2023

Vat photopolymerization (VP), including stereolithography (SLA), digital light processing (DLP), and volumetric printing, employs UV or visible to solidify cell-laden photoactive bioresin contained within a vat in point-by-point, layer-by-layer, manner. VP-based bioprinting has garnered substantial attention both academia industry due its unprecedented control over printing resolution accuracy, as well rapid speed. It holds tremendous potential for the fabrication of tissue- organ-like structures field regenerative medicine. This review summarizes recent progress VP fields tissue engineering First, it introduces mechanism photopolymerization, followed by an explanation technique commonly used biomaterials. Furthermore, application was discussed. Finally, challenges facing are discussed, future trends projected.

Language: Английский

Citations

25
Graphene Oxide Based Transparent Resins For Accurate 3D Printing of Conductive Materials DOI
David Tilve-Martínez, Wilfrid Néri,

Dylan Horaud

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: Feb. 25, 2023

Abstract Digital Light Processing (DLP) allows the fast realization of 3D objects with high spatial resolution. However, DLP is limited to transparent resins, and therefore not well suited for printing electrically conductive materials. Manufacturing materials will significantly broaden spectrum applications technology. But metals or carbon‐based fillers absorb scatter light; inhibiting thereby photopolymerization, lowering In this study, UV liquid crystal graphene oxide (GO) used as precursor generating in situ particles. The GO are added a photopolymerizable resin via an original solvent exchange process. By contrast earlier contributions, absence drying during all process material be transferred monolayers limit scattering. scattering absorption high‐resolution printing. chosen sustain temperature enable efficient thermal reduction into reduced (rGO) that conductive. rGO particles form percolated networks conductivities up 1.2 × 10 −2 S m −1 . present method appears way reconcile technology manufacturing objects.

Language: Английский

Citations

24
Advances in volumetric bioprinting DOI

Sibo Jing,

Liming Lian, Yingying Hou

et al.

Biofabrication, Journal Year: 2023, Volume and Issue: 16(1), P. 012004 - 012004

Published: Nov. 3, 2023

The three-dimensional (3D) bioprinting technologies are suitable for biomedical applications owing to their ability manufacture complex and high-precision tissue constructs. However, the slow printing speed of current layer-by-layer (bio)printing modality is major limitation in biofabrication field. To overcome this issue, volumetric (VBP) developed. VBP changes layer-wise operation conventional devices, permitting creation geometrically complex, centimeter-scale constructs tens seconds. next step onward from sequential methods, opening new avenues fast additive manufacturing fields engineering, regenerative medicine, personalized drug testing, soft robotics, etc. Therefore, review introduces principles hardware designs VBP-based techniques; then focuses on recent advances (bio)inks applications. Lastly, limitations discussed together with future direction research.

Language: Английский

Citations

23