Synergizing Algorithmic Design, Photoclick Chemistry and Multi‐Material Volumetric Printing for Accelerating Complex Shape Engineering DOI Creative Commons
Parth Chansoria, Dominic Rütsche, Anny Wang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 3, 2023

The field of biomedical design and manufacturing has been rapidly evolving, with implants grafts featuring complex 3D constraints materials distributions. By combining a new coding-based modeling approach high-throughput volumetric printing, is demonstrated to transform the way shapes are designed fabricated for applications. Here, an algorithmic voxel-based used that can generate large library porous structures, auxetic meshes cylinders, or perfusable constructs. deploying finite cell within framework, arrays selected designs be computationally modeled. Finally, schemes in conjunction approaches multi-material printing based on thiol-ene photoclick chemistry fabricate heterogeneous shapes. Collectively, design, fabrication techniques toward wide spectrum products such as actuators, grafts, tissue disease models.

Language: Английский

Light-sheet 3D microprinting via two-colour two-step absorption DOI
Vincent Hahn, Pascal Rietz,

Frank Hermann

et al.

Nature Photonics, Journal Year: 2022, Volume and Issue: 16(11), P. 784 - 791

Published: Oct. 13, 2022

Language: Английский

Citations

96
Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering DOI
Shenqiang Wang, Sheng Zhao, Jicheng Yu

et al.

Small, Journal Year: 2022, Volume and Issue: 18(36)

Published: June 17, 2022

The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and hierarchical organizations for translational engineering remains challenging. printing, an additive manufacturing technique, has revolutionized the field by fabricating biomimetic precisely controlled composition, spatial distribution, architecture that can replicate both biological functional native tissues. Therefore, printing is gaining increasing attention as a viable option to advance personalized therapy various diseases regenerating desired This review outlines recently developed techniques clinical translation specifically summarizes applications these approaches cartilage, bone, osteochondral current challenges future perspectives technology are also discussed.

Language: Английский

Citations

86
Controlling Light in Scattering Materials for Volumetric Additive Manufacturing DOI
Jorge Madrid‐Wolff, Antoine Boniface, Damien Loterie

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: May 18, 2022

3D printing has revolutionized the manufacturing of volumetric components and structures in many areas. Several fully light-based techniques have been recently developed thanks to advent photocurable resins, promising reach unprecedented short print time (down a few tens seconds) while keeping good resolution (around 100 μm). However, these new approaches only work with homogeneous relatively transparent resins so that light patterns used for photo-polymerization are not scrambled along their propagation. Herein, method takes into account scattering resin prior computing projection is proposed. Using tomographic printer, it experimentally demonstrated implementation this correction critical when objects whose size exceeds mean free path. To show broad applicability technique, functional high fidelity fabricated hard organic acrylates soft cell-laden hydrogels (at 4 million cells mL-1 ). This opens up perspectives inside turbid materials particular interesting applications bioprinting constructs.

Language: Английский

Citations

77
Light-based vat-polymerization bioprinting DOI
Riccardo Levato, Oksana Y. Dudaryeva, Carlos Ezio Garciamendez‐Mijares

et al.

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: June 22, 2023

Language: Английский

Citations

75
The 3D Bioprinted Scaffolds for Wound Healing DOI Creative Commons
Pablo Edmundo Antezana, Sofía Municoy, María I. Álvarez Echazú

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 464 - 464

Published: Feb. 21, 2022

Skin tissue engineering and regeneration aim at repairing defective skin injuries progress in wound healing. Until now, even though several developments are made this field, it is still challenging to face the complexity of with current methods fabrication. In review, short, state-of-the-art on using 3D bioprinting as a new tool described. The summary bioink formulations, parameters, properties discussed. Finally, representative number examples advances field together limitations future needs provided.

Language: Английский

Citations

72
Introducing Dynamic Bonds in Light‐based 3D Printing DOI Creative Commons
Guangda Zhu, Hannes A. Houck, Christoph A. Spiegel

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(20)

Published: April 23, 2023

Abstract Light‐based 3D printing has received significant attention due to several advantages including high speed and resolution. Along with the development of new technologies, material design is key for next generation light‐based printing. Conventional printable polymeric materials, also known as photopolymers or photoresins, often lead thermosets–polymer networks cross‐linked by permanent covalent bonds which bring limited adaptability restricted reprocessability. Dynamic that can reversibly break reform enable network rearrangement, thereby offering unprecedented properties materials such adaptability, self‐healing, recycling capabilities. Hence, introducing dynamic into a promising strategy further expand meet diverse application scenarios printed multi‐functional moreover more demanding sustainable nature‐inspired considerations (e.g., self‐healing). Herein, an overview recent advances in printing, aiming bridge these two research fields presented. Importantly, current challenges are analyzed perspectives developing their potential applications provided.

Language: Английский

Citations

50
Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem‐Cell Niches for In Vitro Models DOI Creative Commons
Francesca K. Lewns, Olga Tsigkou, Liam R. Cox

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: April 23, 2023

Advances in bioprinting have enabled the fabrication of complex tissue constructs with high speed and resolution. However, there remains significant structural biological complexity within tissues that is unable to recapitulate. Bone, for example, has a hierarchical organization ranging from molecular whole organ level. Current techniques materials employed imposed limits on scale, speed, resolution can be achieved, rendering technique reproduce hierarchies cell-matrix interactions are observed bone. The shift toward biomimetic approaches bone engineering, where hydrogels provide biophysical biochemical cues encapsulated cells, promising approach enhancing function development vitro modeling. A major focus modeling creating dynamic microenvironmental niches support, stimulate, direct cellular processes formation remodeling. Hydrogels ideal imitating extracellular matrix since they engineered present various whilst allowing bioprinting. Here, recent advances 3D niche conducive engineering models reviewed.

Language: Английский

Citations

47
Volumetric additive manufacturing: A new frontier in layer-less 3D printing DOI Creative Commons
Daniel J. Whyte, Egan H. Doeven, Alessandra Sutti

et al.

Additive manufacturing, Journal Year: 2024, Volume and Issue: 84, P. 104094 - 104094

Published: March 1, 2024

Volumetric Additive Manufacturing (VAM) is an emerging 3D printing technology that operates by fabricating objects from all points within a medium's volume. This technique capable of producing parts without supporting structures and overprinting around existing structures. Notably, the approach VAM utilises to print time efficient compared traditional additive manufacturing methods with times being measured in seconds minutes instead hours. As this there little comparison or synthesis reported so far literature, thus primary objective review address issue providing comprehensive analysis VAM, delving into its applications, challenges it faces, research advancements made area. also investigates how new are investigated on, literature. In order achieve goal structured literature was conducted thoroughly examine current state VAM. found 30 papers, which were used categorise different methods, explore potential various fields, formulate definition for differentiate other technologies. A key finding while offers rapid fabrication capabilities, currently faces several constraints. These include limited availability commercial printers, complex methodologies, restricted range compatible materials, need specialised equipment. Collectively, these factors could serve as barriers broader adoption technology. addition, lack homogeneity parameters investigate report makes difficult compare contrast works against published field progresses, addressing will be essential unlock applications increase one first explicitly focus on entirety offering valuable insights present directions future research.

Language: Английский

Citations

21
Holographic tomographic volumetric additive manufacturing DOI Creative Commons
Maria Isabel Álvarez-Castaño, Andreas Erik Gejl Madsen, Jorge Madrid‐Wolff

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 11, 2025

Language: Английский

Citations

2
A review of materials used in tomographic volumetric additive manufacturing DOI Creative Commons
Jorge Madrid‐Wolff, Joseph Toombs, Riccardo Rizzo

et al.

MRS Communications, Journal Year: 2023, Volume and Issue: 13(5), P. 764 - 785

Published: Aug. 29, 2023

Volumetric additive manufacturing is a novel fabrication method allowing rapid, freeform, layer-less 3D printing. Analogous to computer tomography (CT), the projects dynamic light patterns into rotating vat of photosensitive resin. These build up three-dimensional energy dose within resin, solidifying volume desired object seconds. Departing from established sequential methods like stereolithography or digital printing, volumetric offers new opportunities for materials that can be used include viscous acrylates and elastomers, epoxies (and orthogonal epoxy-acrylate formulations with spatially controlled stiffness) formulations, tunable stiffness thiol-enes shape memory foams, polymer derived ceramics, silica-nanocomposite based glass, gelatin-based hydrogels cell-laden biofabrication. Here we review these materials, highlight challenges adapt them manufacturing, discuss perspectives they present.

Language: Английский

Citations

32