Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Language: Английский

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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Jan. 27, 2022

The emergence of bacterial resistance due to the evolution microbes under antibiotic selection pressure, and their ability form biofilm, has necessitated development alternative antimicrobial therapeutics. Physical stimulation, as a powerful method disrupt microbial structure, been widely used in food industrial sterilization. With advances nanotechnology, nanophysical strategies (NPAS) have provided unprecedented opportunities treat antibiotic-resistant infections, via combination nanomaterials physical stimulations. In this review, NPAS are categorized according modes which include mechanical, optical, magnetic, acoustic, electrical signals. biomedical applications combating infections systematically introduced, with focus on design mechanisms. Current challenges further perspectives clinical treatment also summarized discussed highlight potential use settings. authors hope that review will attract more researchers advance promising field NPAS, provide new insights for designing combat resistance.

Language: Английский

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Single Copper Atom Photocatalyst Powers an Integrated Catalytic Cascade for Drug-Resistant Bacteria Elimination

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 2980 - 2991

Published: Jan. 25, 2023

To address the issue posed by drug-resistant bacteria and inspired natural antimicrobial enzymes, we report atomically doped copper on guanine-derived nanosheets (G–Cu) that possess integrated catalytic cascade property of glucose oxidase peroxidase, yielding free radicals to eliminate upon light irradiation. Density functional theory calculations demonstrate could notably promote oxygen activation H2O2 splitting G–Cu complexes. Further all-atom simulation experimental data indicate lysis is mainly induced cell membrane damage elevation intracellular reactive species. Lastly, complexes efficiently staphylococci in infected wounds accelerate their closure a murine model, with negligible side effects normal tissues. Therefore, our may provide an efficient nonantibiotic alternative current treatments for bacterial infections.

Language: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761

Published: Jan. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Language: Английский

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Metal-Based Nanoparticles as Antimicrobial Agents: A Review

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 2529 - 2545

Published: Jan. 18, 2024

Antibiotic abuse has become a rising public health concern in recent years, leading to dangerous bacteria developing antibiotic resistance most medicines currently use. Traditional antimicrobial medications have been helpful the early stages of treating numerous forms serious bacterial infectious diseases; however, despite significant therapeutic benefit, there are number issues with follow-up treatment. Metal-based nanomaterials, which properties including difficulty establishing drug and advantages reduced cytotoxicity, considered promising substances. This review discusses important types metal-based nanoparticles (MNPs), such as copper, titanium, zinc oxide, etc., focus on applications gold- silver-based nanoparticles. Furthermore, advanced research progress MNPs agents stimuli-responsive metal nanoparticle strategies working under photothermal, magnetic, pH stimulation also summarized this article. In general, advancement technology, materials based will offer excellent prospects for improving applications.

Language: Английский

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Electron Lock Manipulates the Catalytic Selectivity of Nanozyme

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3814 - 3825

Published: Jan. 17, 2024

Nanomaterials with enzyme-mimicking functions, termed nanozymes, offer attractive opportunities for biocatalysis and biomedicine. However, manipulating nanozyme selectivity poses an insurmountable hurdle. Here, we propose the concept of energy-governed electron lock that controls transfer between substrates to achieve manipulation enzyme-like catalysis. An can be constructed opened, via modulating nanozyme's energy match barrier enzymatic reactions. iron-doped carbon dot (FeCD) easy-to-regulate is selected as a proof concept. Through regulating conduction band which dominates energy, activatable oxidase selective peroxidase (POD) substrate affinity 123-fold higher than natural horseradish (HRP) achieved. Furthermore, while maintaining selectivity, FeCDs exhibit catalytic kinetics comparable HRP upon transforming photons into electrons. Superior efficient catalysis, undetectable biotoxicity energize potent targeted drugs on antibiotic-resistant bacterial abscesses. provides robust strategy manipulate toward advanced nanozymes.

Language: Английский

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Metal-based nanomaterials with enzyme-like characteristics for bacterial rapid detection and control

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215799 - 215799

Published: April 1, 2024

Language: Английский

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Multifunctional Roles of Ionic Microenvironments in the Preparation, Modification, and Application of g‐C₃N₄

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract As a visible light‐responsive metal‐free polymer semiconductor, graphitic carbon nitride (g‐C 3 N 4 ) has garnered increasing attention in photocatalysis but needs structural modification and functional enhancement. Recently, the rational design of ionic microenvironments (IMEs) by leveraging tunability various ions to endow catalysts with tailored functionalities been elevated hot direction. To elucidate their respective effects on g‐C , IMEs are categorized into three types, namely plasma IMEs, organic inorganic according criteria external field dependence, cation type, application scenarios. These promotions include facilitated preparation, diversified modifications, improved efficiencies. First, participate constructing functionalized microenvironment through dynamic interactions precursor during facilitating customization, crystal nucleation growth, surface performance enhancement, process cleanliness. Second, create tunable for post‐modification functioning as an electron reservoir, modifier, substrate adsorbent, stabilizer. Lastly, synergistic effect between IME they achieve targeted product regulation, enhanced chemical stability, efficient adsorption, potential fields like catalysis, energy storage, gas adsorption. Also, limitations, challenges, prospects strategies discussed, offering systematic insights IMEs‐based structure‐activity relationships 4.

Language: Английский

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GSH-depleting and H2O2-self-supplying hybrid nanozymes for intensive catalytic antibacterial therapy by photothermal-augmented co-catalysis

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 155, P. 588 - 600

Published: Oct. 31, 2022

Language: Английский

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Ultrasound activatable microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 158, P. 811 - 826

Published: Dec. 24, 2022

Language: Английский

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