ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(47), P. 54207 - 54220
Published: Nov. 17, 2023
Tumor
drug
resistance
caused
by
the
tumor
microenvironment
is
an
extremely
difficult
problem
for
researchers
to
solve.
Nanoplatforms
that
integrate
diagnosis
and
treatment
have
great
advantages
in
treatment,
but
design
synthesis
of
simple
efficient
nanoplatforms
still
face
tremendous
challenges.
In
this
study,
a
novel
Mn/Au@ir820/GA-CD133
nanoprobe
was
developed.
The
manganese
dioxide/gold
particles
were
prepared
coprecipitation/assembly,
chemically
coupled
with
CD133
antibody,
finally
loaded
photosensitive
IR820
heat
shock
protein
inhibitor
Ganetespib.
demonstrated
good
tumor-targeting
ability,
increased
level
singlet
oxygen
produced
from
laser
irradiation
effectively
alleviating
hypoxia,
decreased
threshold
tolerance
downregulating
expression
HSP90
tissues.
This
successfully
inhibited
growth
progression
tissues
tumor-bearing
mouse
model
improving
effectiveness
photodynamic
low-temperature
photothermal
combination
therapy.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 303 - 326
Published: April 18, 2023
Microneedle,
as
a
novel
drug
delivery
system,
has
attracted
widespread
attention
due
to
its
non-invasiveness,
painless
and
simple
administration,
controllable
delivery,
diverse
cargo
loading
capacity.
Although
microneedles
are
initially
designed
penetrate
stratum
corneum
of
skin
for
transdermal
they,
recently,
have
been
used
promote
wound
healing
regeneration
tissues
organs
the
results
promising.
Despite
there
reviews
about
microneedles,
few
them
focus
on
tissue
regeneration.
Here,
we
review
recent
advances
in
this
field.
We
first
give
an
overview
microneedle
system
terms
potential
cargos
(e.g.,
small
molecules,
macromolecules,
nucleic
acids,
nanoparticles,
extracellular
vesicle,
cells),
structural
designs
multidrug
structures,
adhesive
structures),
material
selection,
release
mechanisms.
Then
briefly
summarize
different
fabrication
methods,
including
their
advantages
limitations.
finally
progress
microneedle-assisted
skin,
cardiac,
bone,
tendon,
ocular,
vascular,
oral,
hair,
spinal
cord,
uterine
tissues).
expect
that
our
article
would
serve
guideline
readers
design
systems
according
applications,
structure
design,
achieving
better
efficacy.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100559 - 100559
Published: Jan. 21, 2023
With
the
widespread
prevalence
of
drug-resistant
pathogens,
traditional
antibiotics
have
limited
effectiveness
and
do
not
yield
desired
outcomes.
Recently,
alternative
antibacterial
therapies
based
on
ultrasound
(US)
been
explored
to
overcome
crisis
bacterial
pathogens.
Antimicrobial
sonodynamic
therapy
(aSDT)
offers
an
excellent
solution
that
relies
US
irradiation
produce
reactive
oxygen
species
(ROS)
achieve
antibiotic-free
mediated
antimicrobial
effects.
In
addition,
aSDT
possesses
advantage
superior
tissue
penetrability
compared
light
irradiation,
demonstrating
great
feasibility
in
treating
deep
infections.
Although
existing
conventional
sonosensitizers
can
ROS
for
activity,
some
limitations,
such
as
low
penetration
rate,
nonspecific
distribution
poor
production
under
hypoxic
conditions,
result
suboptimal
sterilization
aSDT.
emerging
nanosonosensitizers
enormous
advantages
high-performance
agents
aSDT,
which
deficiencies
described
above.
Thus,
nanosonosensitizer-mediated
has
a
bright
future
management
This
review
classifies
current
available
provides
overview
mechanisms,
biomedical
applications,
recent
advances
perspectives
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2298 - 2316
Published: Jan. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: May 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
100, P. 106617 - 106617
Published: Sept. 23, 2023
The
rapid
spread
and
uncontrollable
evolution
of
antibiotic-resistant
bacteria
have
already
become
urgent
global
to
treat
bacterial
infections.
Sonodynamic
therapy
(SDT),
a
noninvasive
effective
therapeutic
strategy,
has
broadened
the
way
toward
dealing
with
biofilms,
which
base
on
ultrasound
(US)
sonosensitizer.
Sonosensitizer,
based
small
organic
molecules
or
inorganic
nanoparticles,
is
essential
SDT
process.
Thus,
it
meaningful
design
sonosensitizer-loaded
nanoplatform
synthesize
an
efficient
effect.
In
this
review,
we
initially
summarize
probable
SDT-based
antibacterial
mechanisms
systematically
discuss
current
advancement
in
different
(including
for
small-molecule
sonosensitizer
delivery
as
sonosensitizer)
infection
therapy.
addition,
biomedical
applications
SDT-involved
multifunctional
nanoplatforms
are
also
discussed.
We
believe
innovative
would
highly
next-generation
tool
combating
infection.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(23)
Published: May 9, 2023
Phototherapy
and
sonotherapy
are
recognized
by
scientific
medicine
as
effective
strategies
for
treating
certain
cancers.
However,
these
have
limitations
such
an
inability
to
penetrate
deeper
tissues
overcome
the
antioxidant
tumor
microenvironment.
In
this
study,
a
novel
"BH"
interfacial-confined
coordination
strategy
synthesize
hyaluronic
acid-functionalized
single
copper
atoms
dispersed
over
boron
imidazolate
framework-derived
nanocubes
(HA-NC_Cu)
achieve
sonothermal-catalytic
synergistic
therapy
is
reported.
Notably,
HA-NC_Cu
demonstrates
exceptional
sonothermal
conversion
performance
under
low-intensity
ultrasound
irradiation,
attained
through
intermolecular
lattice
vibrations.
addition,
it
shows
promise
efficient
biocatalyst,
able
generate
high-toxicity
hydroxyl
radicals
in
response
tumor-endogenous
hydrogen
peroxide
glutathione.
Density
functional
theory
calculations
reveal
that
superior
parallel
catalytic
of
originates
from
CuN4
C/B
active
sites.
Both
vitro
vivo
evaluations
consistently
demonstrate
significantly
improves
inhibition
rate
(86.9%)
long-term
survival
(100%).
combination
with
triggers
dual
death
pathway
apoptosis
ferroptosis
MDA-MB-231
breast
cancer
cells,
comprehensively
limiting
primary
triple-negative
cancer.
This
study
highlights
applications
single-atom-coordinated
nanotherapeutics
therapy,
which
may
create
new
opportunities
biomedical
research.
