Self‐Sacrificially Degradable Pseudo‐Semiconducting Polymer Nanoparticles that Integrate NIR‐II Fluorescence Bioimaging, Photodynamic Immunotherapy, and Photo‐Activated Chemotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(34)

Published: July 12, 2022

Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, clinical application is still hampered by poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) reported. The PSP can further co-assemble with an amphiphilic polyester pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX ), which are denoted as NP@PEDOX /PSP. /PSP accumulate at tumor sites generate ROS immunotherapy well near-infrared-II (NIR-II) bioimaging upon irradition 808 nm. could break up PEDOX , resulting rapid release PACT. Finally, both degraded sacrificially intracellular glutathione (GSH), the dissociation of This work highlights degradable PACT therapy.

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(16)

Published: March 27, 2022

Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)-sensitive thioketal bonds are designed. Triphenylphosphine (PPh

Language: Английский

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Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated Macrophage Reprogramming

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)

Published: June 7, 2023

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed deliver agent, i.e., regorafenib (Reg) nanoparticles (NP-PDT@Reg). NP-PDT@Reg under 808 nm laser irradiation (NP-PDT@Reg + L) efficiently release Reg improve via normalization, making more oxygen enter tumors. Moreover, L further result generation reactive species (ROS) eradicate cells while inducing immunogenic cell death (ICD) activate anti-tumor responses. In addition, reprogram TAM from pro-tumor M2 phenotype tumor-killing M1 well, thereby reversing immunosuppressive microenvironment. Taken together, current study provides an innovative perspective on development novel nanomaterials limitations immunotherapy.

Language: Английский

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Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 2, 2023

Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove primary tumor, remain poorly accessible. To overcome this limitation, herein, development a theranostic nanomaterial by incorporating chromophore for imaging and photosensitizer treatment metastatic tumor sites is presented. The mechanism action reveals that nanoparticles able intervene local generation cellular damage through photodynamic therapy as well systemic induction an immune response immunotherapy upon inhibition mTOR signaling pathway which crucial importance onset, progression spreading. strongly reduce volume eradicates in breast cancer multi-drug resistant patient-derived hepatocellular carcinoma models female mice.

Language: Английский

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NIR‐II Light Accelerated Prodrug Reduction of Pt(IV)‐Incorporating Pseudo Semiconducting Polymers for Robust Degradation and Maximized Photothermal/Chemo‐Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(28)

Published: April 5, 2023

Abstract Selective activation of Pt(IV) prodrugs within tumors is particularly attractive because their low damage to normal tissues. However, current common via chemical/photoreduction into Pt(II) counterparts limited by undesirable spatial–temporal control over this reduction process and the ineffective tissue penetration depth light. Here, a pseudo‐conjugated‐polymer designed Stille polymerization, resulting in PSP‐Pt with prodrug oxaliplatin (Oxa(IV)) polymer main chain that can be activated NIR‐II co‐assemble commercially available lipid polymer, namely mPEG 2k ‐DSPE, NP . Under 1064 nm light irradiation, photoactivated accelerate release oxaliplatin, thereby killing cancer cells photothermal effect chemo‐immunotherapy inside mouse model CT26 colon cancer. This work reports application for accelerating tumor therapy.

Language: Английский

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Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 5, 2023

Promoting innate immunity through pyroptosis induction or the cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) pathway activation has emerged as a potent approach to counteract immunosuppressive tumor microenvironment and elicit systemic antitumor immunity. However, current inducers STING agonists often suffer from limitations including instability, unpredictable side effects, inadequate intracellular expression gasdermin STING. Here, tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic simultaneously activate cGAS-STING in light-controlled manner is constructed. This involves development oxidation-sensitive nanoparticles (NP1) loaded photosensitizer TBE, along decitabine nanomicelles (NP2). NP2 enables restoration E (GSDME) expression, while NP1-mediated PDT facilitates release DNA fragments damaged mitochondria potentiate pathway, promotes caspase-3 cleave upregulated GSDME into pore-forming GSDME-N terminal. Subsequently, released inflammatory cytokines facilitate maturation antigen-presentation cells, triggering T cell-mediated Overall, this study presents an elaborate strategy for simultaneous photoactivation enabling targeted photoimmunotherapy immunotolerant tumors. innovative holds significant promise overcoming associated existing therapeutic modalities represents valuable avenue future clinical applications.

Language: Английский

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Molecular Evolution of Acceptor–Donor–Acceptor‐type Conjugated Oligomer Nanoparticles for Efficient Photothermal Antimicrobial Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: Feb. 22, 2023

Abstract Infectious diseases (such as wound infections) caused by pathogenic microorganisms can lead to serious consequences and even threaten life. The emergence of drug‐resistant bacteria has severely prevented the validity traditional antibiotics. Therefore, developing novel antimicrobial strategies without holds great promise for maximizing efficacy minimizing risk drug‐resistance resistant bacterial infections. Herein, near‐infrared (NIR)‐absorbing A–D–A type conjugated oligomers with a tunable backbone are designed synthesized regulating their photothermal conversion. After being assembled into nanoparticles, oligomer CP‐F8P nanoparticles (NPs) containing strong electron‐donating component show strongest conversion efficiency 81.6%. low concentration NPs receive over 99% against Amp r E. coli , S. aureus C. albicans upon NIR irradiation, phototherapy treatment effectively promote healing in diabetic mice good biocompatibility. This work provides ideas design efficient NIR‐activated reagents microbial

Language: Английский

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Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal‐Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment

Advanced Science, Journal Year: 2023, Volume and Issue: 11(9)

Published: Dec. 14, 2023

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and cartilage destruction. The severity of OA highly associated with the imbalance between M1 M2 synovial macrophages. In this study, novel strategy designed to modulate macrophage polarization reducing intracellular reactive oxygen species (ROS) levels regulating mitochondrial function. A ROS‐responsive polymer synthesized self‐assemble astaxanthin autophagy activator rapamycin form nanoparticles (NP@Poly RHAPM ). vitro experiments show that NP@Poly significantly reduced ROS levels. Furthermore, restored membrane potential, increased glutathione (GSH) levels, promoted autophagy, hence successfully repolarizing macrophages into phenotype. This repolarization enhanced chondrocyte proliferation vitality while inhibiting apoptosis. vivo utilizing an anterior cruciate ligament transection (ACLT)‐induced mouse model revealed anti‐inflammatory cartilage‐protective effects , effectively mitigating progression. Consequently, findings suggest intra‐articular delivery nanocarrier systems holds significant promise as potential effective therapeutic for treatment.

Language: Английский

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Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14085 - 14122

Published: May 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Language: Английский

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