Nanomaterials-based photothermal therapies for antibacterial applications

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

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Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: Aug. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Language: Английский

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From hemostasis to proliferation: Accelerating the infected wound healing through a comprehensive repair strategy based on GA/OKGM hydrogel loaded with MXene@TiO2 nanosheets

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122548 - 122548

Published: March 27, 2024

Language: Английский

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Sensing, Imaging, and Therapeutic Strategies Endowing by Conjugate Polymers for Precision Medicine

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)

Published: Feb. 7, 2024

Abstract Conjugated polymers (CPs) have promising applications in biomedical fields, such as disease monitoring, real‐time imaging diagnosis, and treatment. As a luminescent material with tunable emission, high brightness excellent stability, CPs are widely used fluorescent probes biological detection imaging. Rational molecular design structural optimization broadened absorption/emission range of CPs, which more conductive for diagnosis precision therapy. This review provides comprehensive overview recent advances the application aiming to elucidate their functional relationships. The fluorescence properties mechanism signal amplification first discussed, followed by an elucidation emerging detection. Subsequently, CPs‐based systems therapeutic strategies illustrated systematically. Finally, advancements utilizing electroactive materials bioelectronic devices also investigated. Moreover, challenges outlooks medicine discussed. Through this systematic review, it is hoped highlight frontier progress promote new breakthroughs fundamental research clinical transformation.

Language: Английский

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Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16011 - 16028

Published: March 26, 2024

Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial conquer problem antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen–carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under near-infrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen(1O2), it also high photothermal conversion effect, which not only facilitates elimination bacteria but improves efficiency reactive oxygen species (ROS) production accelerates consumption GSH. shows lower hemolytic rate better cytocompatibility than CuCo/NC positive charge macroporous skeleton restricting negatively charged range ROS destruction, strengthening efficiency. Comparatively, stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) ampicillin-resistant Escherichia coli (AmprE. coli) through destroying cell membranes negligible occurrence AMR. More importantly, plus can exhibit satisfactory performance absence H2O2, avoiding toxicity from high-concentration H2O2. vivo evaluation conducted using mouse wound infection model histological analyses, results show that upon suppress promote healing, without causing inflammation tissue adhesions.

Language: Английский

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Rationally Manipulating Molecular Planarity to Improve Molar Absorptivity, NIR-II Brightness, and Photothermal Effect for Tumor Phototheranostics

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123113 - 123113

Published: Jan. 17, 2025

Language: Английский

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Recent Progress of Photothermal Therapy Based on Conjugated Nanomaterials in Combating Microbial Infections

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2269 - 2269

Published: Aug. 7, 2023

Photothermal therapy has the advantages of non-invasiveness, low toxicity, simple operation, a broad spectrum antibacterial ability, and non-proneness to developing drug resistance, which provide it with irreplaceable superiority in fighting against microbial infection. The effect photothermal is closely related choice agent. Conjugated nanomaterials are potential candidates for agents because their easy modification, excellent conversion efficiency, good photostability, biodegradability. In this paper, application based on conjugated antimicrobial treatment reviewed, including small molecules, oligomers, polymers, pseudo-conjugated polymers. At same time, combination (PTT) photodynamic (PDT) briefly introduced. Finally, research status, limitations, prospects using as discussed.

Language: Английский

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Multifunctional Gold–Silver–Carbon Quantum Dots Nano-Hybrid Composite: Advancing Antibacterial Wound Healing and Cell Proliferation

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(34), P. 40241 - 40254

Published: Aug. 21, 2023

The urgent need for innovative materials that effectively eliminate bacteria while promoting cell growth to accelerate wound healing has led the exploration of new options, as current antimicrobial nanoparticles often exhibit high cytotoxicity, which hinders closure. In this study, a nano-hybrid composite, named gold–silver–carbon quantum dots (AuAg-CDs), was prepared by embedding gold and silver nanoclusters into carbon dots. AuAg-CDs composite demonstrates remarkable biocompatibility, displays potent antibacterial activity, possesses unique capability promote proliferation. By physically disrupting bacterial membranes mammalian proliferation, emerges highly promising material applications. underlying mechanism multifunctional investigated through comprehensive analyses encompassing morphology, membrane potential, levels reactive oxygen species (ROS), adenosine triphosphate (ATP) production in both cells. Additionally, were incorporated alginate create hydrogel dressing, underwent evaluation using animal models. results underscore potential dressing facilitating proliferation fibroblasts combating infections. significance designing nanomaterials address challenges associated with pathogenic infections regenerative medicine is highlighted paving way future advancements these fields.

Language: Английский

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Engineering Carbon Nanotube‐Based Photoactive COF to Synergistically Arm a Multifunctional Antibacterial Hydrogel

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(11)

Published: Dec. 6, 2023

Abstract Enhancing the covalent organic framework (COF)’s photocatalytic ability synergistically with gelling formulations remains an urgent challenge for extended bio‐applications. Herein, COF is homogeneously coated on oxidized carbon nanotube (OCNT) and coordinated by Fe 3+ to obtain tubular nanocomplex OCNT@COF‐Fe (O@CF). The results showed that photodynamic reactive oxygen species (ROS) generation of O@CF enhanced due wrapped OCNT , which can respectively serve as intermolecular charge transfer channel electron acceptors/substrates (O 2 H O) adsorbent narrow energy band gaps, increase light absorption, decrease photogenerated carrier recombination. Synergistically, exhibited pH‐dependent peroxidase catalase activities, further ROS relieved hypoxia, respectively. Meanwhile, possessed degradation coatings‐dependent photothermal performances. Then, evenly incorporated into Schiff base hydrogel via coating‐participated cross‐linking, electroconductive OCNT@COF‐Fe@Gel (O@CF@G). This O@CF@G not only improve mechanical properties pure gel but also inherit multifunction O@CF. Consequently, it well adhere diabetic wounds imbibition, drug‐resistant biofilm elimination, gram‐positive negative bacteria killing, hypoxia alleviation, intercellular electrical signal conduction, thus accelerating wound healing.

Language: Английский

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Side Chain Programming Synchronously Enhances the Photothermal Conversion Efficiency and Photodynamic Activity of A–D–A Photosensitizers

ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(5), P. 489 - 494

Published: April 12, 2024

Synchronously improving the photothermal conversion efficiency and photodynamic activity of organic small molecule photosensitizers is crucial for their further wide application in cancer treatment. Recently, emerging A–D–A photosensitizer-based phototherapy systems have attracted great interest due to plentiful inherent merits. Herein, we propose a design strategy with synchronously enhanced reactive oxygen species (ROS) generation efficiencies. Side chain programming carried out three (IDT-H, IDT-Br, IDT-I) containing hexyl, bromohexyl, iodohexyl side chains, respectively. Theoretical calculations confirm that bulky iodine atom could weaken intermolecular π–π stacking enhance spin–orbit coupling constants IDT-I. These molecular mechanisms enable IDT-I nanoparticles (NPs) exhibit 2.4-fold 1.7-fold higher ROS than IDT-H NPs IDT-Br NPs, respectively, as well highest efficiency. Both experimental results vitro vivo verify are perfectly qualified mission synergistic therapy. Therefore, this contribution, provide promising perspective simultaneously improved therapy ability.

Language: Английский

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