Theranostics,
Journal Year:
2023,
Volume and Issue:
13(15), P. 5386 - 5417
Published: Jan. 1, 2023
Stimuli-activatable
strategies
prevail
in
the
design
of
nanomedicine
for
cancer
theranostics.Upon
exposure
to
endogenous/exogenous
stimuli,
stimuli-activatable
could
be
self-assembled,
disassembled,
or
functionally
activated
improve
its
biosafety
and
diagnostic/therapeutic
potency.A
myriad
tumor-specific
features,
including
a
low
pH,
high
redox
level,
overexpressed
enzymes,
along
with
exogenous
physical
stimulation
sources
(light,
ultrasound,
magnet,
radiation)
have
been
considered
nano-medicinal
products.Recently,
novel
stimuli
explored
elegant
designs
emerged
nanomedicine.In
addition,
multi-functional
theranostic
has
employed
imaging-guided
image-assisted
antitumor
therapy.In
this
review,
we
rationalize
development
clinical
pressing
needs.Stimuli-activatable
self-assembly,
disassembly
functional
activation
approaches
developing
realize
better
efficacy
are
elaborated
state-of-the-art
advances
their
structural
detailed.A
reflection,
status,
future
perspectives
provided.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Aug. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(46)
Published: Sept. 28, 2023
Abstract
To
realize
sensing
and
labeling
biomarkers
is
quite
challenging
in
terms
of
designing
multimodal
imaging
probes.
In
this
study,
we
developed
a
novel
β
‐galactosidase
(
‐gal)
activated
bimodal
probe
that
combines
near‐infrared
(NIR)
fluorescence
magnetic
resonance
(MRI)
to
enable
real‐time
visualization
activity
living
organisms.
Upon
‐gal
activation,
Gal‐Cy‐Gd‐1
exhibits
remarkable
42‐fold
increase
NIR
intensity
at
717
nm,
allowing
covalent
adjacent
target
enzymes
or
proteins
avoiding
molecular
escape
promote
accumulation
the
tumor
site.
This
reaction
enhances
longitudinal
relaxivity
by
approximately
1.9
times,
facilitating
high‐resolution
MRI.
The
unique
features
precise
live
cells
mice.
probe's
utilization
aids
identifying
situ
ovarian
tumors,
offering
valuable
assistance
removal
tissue
during
surgical
procedures
fusion
MRI
activation
through
self‐immobilizing
provides
robust
approach
for
visualizing
activity.
Moreover,
sets
groundwork
developing
other
activatable
probes,
vivo
enzyme
localization.
