Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149643 - 149643
Published: Feb. 17, 2024
Language: Английский
Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 197 - 235
Published: Dec. 23, 2022
Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause death worldwide. Wound dressings necessary to facilitate wound treatment. Engineering may substantially reduce healing time, risk recurrent infections, disability costs associated. In path engineering an ideal dressing, hydrogels played role. Hydrogels 3D hydrophilic polymeric structures that can provide protective barrier, mimic native extracellular matrix (ECM), humid environment. Due their advantages, (with different architectural, physical, mechanical, biological properties) been extensively explored as dressing platforms. Here we describe recent studies on applications with strong focus interplay between fabrication method used performance achieved. Moreover, review categories additives which enhance regeneration using hydrogel dressings. Hydrogel promises generation smart solutions solve this pressing problem, enabling key functionalities such bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery tissue functionality, overall, accelerated effective healing.
Language: Английский
Citations
223
Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)
Published: May 21, 2022
Abstract The pH value in the wound milieu plays a key role cellular processes and cell cycle involved process of healing. Here, microfluidic assembly technique is employed to fabricate micro‐gel ensembles that can precisely tune surface accelerate consist poly (hydroxypropyl acrylate‐ co ‐acrylic acid)‐magnesium ions (poly‐(HPA‐ ‐AA)‐Mg 2+ ) gel carboxymethyl chitosan (CMCS) gel, which release absorb hydrogen ion (H + separately at different stages healing response evolution microenvironment. By regulating affect proliferation migration on activity various biological factors wound, physiological are greatly facilitated results much accelerated chronic wound. This work presents an effective strategy designing materials with vast potentials for management.
Language: Английский
Citations
166
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: June 10, 2023
Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well inappropriate dosing timing in distinct stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed dynamically modulate immune microenvironment according varied phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, ROS-sensitive MN shell gradually degrades expose core component, which neutralizes various inflammatory factors and promotes phase transition from inflammation proliferation. In addition, released verteporfin inhibits scar formation blocking Engrailed-1 (En1) activation fibroblasts. Our experiments demonstrate that promote scarless repair mouse models both acute wounds, inhibit hypertrophic rabbit ear models.
Language: Английский
Citations
161
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120555 - 120555
Published: Jan. 6, 2023
Language: Английский
Citations
159
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)
Published: April 23, 2023
Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.
Language: Английский
Citations
146
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.
Language: Английский
Citations
135
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125250 - 125250
Published: June 10, 2023
Language: Английский
Citations
111
Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 355 - 376
Published: Nov. 26, 2023
Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They frequently encountered various creatures, including mammals, plants, microbes. The aforementioned commonly derived from renewable sources, possess a notable level of compatibility with living organisms, limited adverse effect on environment. As result, they hold considerable significance development sustainable environmentally friendly goods. In recent times, there has advancement investigation potential uses field biomedicine, specifically relation biomaterials exhibit antibacterial antioxidant characteristics. This review provides comprehensive overview prevalent utilized biomedical domain throughout preceding two decades. this paper, we present examination components typical methods for preparation based polymers. Furthermore, summarize application polymer materials each stage skin wound repair. Finally, key findings insights into limitations current elucidate prospects their future field.
Language: Английский
Citations
107
Advanced Science, Journal Year: 2023, Volume and Issue: 10(16)
Published: April 14, 2023
Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong capability is fabricated through facile mixture of PAA copolymers isoprenyl oxy poly(ethylene glycol) ether tannic (TA). The segments on prevent electrostatic repulsion among ionized carboxyl groups absorbed TA to form coacervates. provides solid dry substrates via multifarious interactions, which endows an adhesive strength skin 23.4 kPa 70% underwater. This achieves desirable self-healing extensible properties suitable for frequently moving joints. These investigations prove that has antibacterial activity, facilitates fibroblast migration, modulates M1/M2 polarization macrophages. In vivo hemorrhage experiments further confirm dramatically shortens hemostatic time from hundreds tens seconds. addition, full-thickness defect demonstrate best therapeutic effect by significantly promoting collagen deposition, angiogenesis, epithelialization. results promising dressing medical translation.
Language: Английский
Citations
100
Bioactive Materials, Journal Year: 2022, Volume and Issue: 20, P. 610 - 626
Published: July 1, 2022
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and coordination complex zinc metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes healing traumatic skin defect burn injury promoting cell proliferation, angiogenesis, collagen formation. Furthermore, find ZnMet could inhibit reactive oxygen species (ROS) production through activation autophagy, thereby protecting from oxidative stress induced damage wound. exerts better effects on wound than ZnCl2 or alone. also displays excellent antibacterial activity against Staphylococcus aureus Escherichia coli, which reduce incidence infections. Collectively, PF127 be used as new drug delivery system for treatment injury. The advantages this are obvious: (1) It convenient to use; (2) can cover irregular sites evenly in liquid state. In with system, establish it potential clinical
Language: Английский
Citations
93