Gene, Journal Year: 2025, Volume and Issue: 960, P. 149549 - 149549
Published: May 6, 2025
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: July 12, 2023
Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.
Language: Английский
Citations
53
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 26, 2025
Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract
Language: Английский
Citations
5
Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25
Published: Jan. 13, 2025
The field of biomedical science has witnessed another milestone with the advent RNA-based therapeutics. This review explores three major RNA molecules, namely: messenger (mRNA), interference technology (RNAi), and Antisense Oligonucleotide (ASO), analyses U.S. Food Drug Administration drugs from 14 pharmaceutical companies in terms targeted genes, diseases types, clinical trials status, mode delivery, year production. Many such are clinically approved or pending approval by (FDA) alongside other leading agencies. Regarding diseases, this article emphasizes cancer therapy, genetic viral infections, two categories drug delivery systems include vectors nanoparticles. Despite tremendous progress made, key issues associated these stability, off-target activities payloads, efficiency cellular uptake, innovative need for engineering techniques modifications. transformative potential therapeutics role technologies addressing needs, paving way a new era precision medicine.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2022, Volume and Issue: 9(26)
Published: July 18, 2022
Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD), Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain difficult to treat by the conventional molecular drugs. In recent years, various gene therapies have come into spotlight versatile therapeutics providing potential prevent these diseases. Despite significant progress that has undoubtedly been achieved in terms of design modification genetic modulators with desired potency minimized unwanted immune responses, efficient safe vivo delivery poses major translational challenges. Various non-viral nanomedicines recently explored circumvent this limitation. review, an overview for CNS is provided describes advances development nanomedicines, including their unique characteristics, chemical modifications, bioconjugations, specific applications those are harnessed deliver therapies.
Language: Английский
Citations
44
The Innovation, Journal Year: 2023, Volume and Issue: 5(1), P. 100548 - 100548
Published: Nov. 27, 2023
•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.
Language: Английский
Citations
34
Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(5), P. 343 - 353
Published: March 11, 2023
The COVID-19 mRNA vaccine was developed by the scalable manufacture of lipid nanoparticles (LNPs) that encapsulate within lipid. There are many potential applications for this large nucleic acid delivery technology, including plasmid DNA gene therapy. However, therapy brain requires LNP across blood-brain barrier (BBB). It is proposed LNPs could be reformulated conjugation receptor-specific monoclonal antibodies (MAbs) to surface. MAb acts as a molecular Trojan horse trigger receptor-mediated transcytosis (RMT) BBB and subsequent localization nucleus transcription therapeutic gene. enable new approaches brain.
Language: Английский
Citations
30
Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(12), P. 1713 - 1730
Published: Aug. 5, 2023
A major challenge in treating central nervous system (CNS) disorders is to achieve adequate drug delivery across the blood-brain barrier (BBB). Receptor-mediated nanodrug as a Trojan horse strategy has become an exciting approach. However, these nanodrugs do not accumulate significantly brain parenchyma, which greatly limits therapeutic effect of drugs. Amplifying efficiency receptor-mediated BBB becomes holy grail treatment CNS disorders.
Language: Английский
Citations
23
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2441 - 2467
Published: March 1, 2024
Abstract: New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from designers. The treatment of neurological conditions, including tumors, stroke, Parkinson's Disease (PD), and Alzheimer's disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration demonstrated the effective application nanomaterials illnesses. Nanocarriers (NCs) made it easier to deliver drugs precisely where they are needed. Thus, most use is various diseases, as this amplifies overall impact medication emphasizes significance nanotherapeutics through gene therapy, enzyme replacement blood-barrier mechanisms. Recent advances led development multifunctional nanotherapeutic agents, a promising disorders. This novel method reduces side effects improves outcomes. review critically assesses efficient nano-based systems light obstacles outstanding achievements. that transfer medications across blood-brain barrier nano-assisted therapies, nano-immunotherapy, nano-gene nano scaffolds, 3D 6D printing, been widely explored study aimed evaluate existing literature regarding can penetrate (BBB) therapeutic agents treat Keywords: delivery, nanomedicine, nano-therapeutics, nanocarriers,
Language: Английский
Citations
13
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 29, 2024
Language: Английский
Citations
13
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 18, 2024
Abstract Ischemic stroke is a complex, high-mortality disease with multifactorial etiology and pathogenesis. Currently, drug therapy mainly used treat ischemic in clinic, but there are still some limitations, such as limited blood-brain barrier (BBB) penetration efficiency, narrow treatment time window side effects. Recent studies have pointed out that delivery systems based on polymeric nanocarriers can effectively improve the insufficient for stroke. They provide neuronal protection by extending plasma half-life of drugs, enhancing drug’s permeability to penetrate BBB, targeting specific structures cells. In this review, we classified delivering drugs introduced their preparation methods. We also evaluated feasibility effectiveness discussed existing limitations prospects treatment. hoped review could theoretical basis future development nanomedicine Graphical
Language: Английский
Citations
10