Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 13, 2024

Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.

Language: Английский

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Landscape of human organoids: Ideal model in clinics and research

The Innovation, Journal Year: 2024, Volume and Issue: 5(3), P. 100620 - 100620

Published: April 1, 2024

In the last decade, organoid research has entered a golden era, signifying pivotal shift in biomedical landscape. The year 2023 marked milestone with publication of thousands papers this arena, reflecting exponential growth. However, amid burgeoning expansion, comprehensive and accurate overview field been conspicuously absent. Our review is intended to bridge gap, providing panoramic view rapidly evolving We meticulously analyze from eight distinctive vantage points, harnessing our rich experience academic research, industrial application, clinical practice. present deep exploration advances technology, underpinned by long-standing involvement arena. narrative traverses historical genesis organoids their transformative impact across various sectors, including oncology, toxicology, drug development. delve into synergy between avant-garde technologies such as synthetic biology single-cell omics discuss role tailoring personalized medicine, enhancing high-throughput screening, constructing physiologically pertinent disease models. analysis reflective discourse provide dive existing landscape emerging trends technology. spotlight technological innovations, methodological evolution, broadening spectrum applications, emphasizing revolutionary influence discovery, other fields. Looking ahead, we cautiously anticipate future developments especially its potential implications for patient care, new avenues research. trust that will be an asset researchers, clinicians, patients keen interest medical strategies. offer broad prospective capabilities encompassing wide range current applications. summary, attempt field. reflections, summaries, projections might useful researchers hope contribute shaping trajectory dynamic advancing

Language: Английский

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Recent research of peptide-based hydrogel in nervous regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 503 - 523

Published: June 29, 2024

Language: Английский

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A Soothing Lavender-Scented Electrospun Fibrous Eye Mask

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5461 - 5461

Published: Nov. 19, 2024

Electrospinning technology has demonstrated extensive applications in biomedical engineering, energy storage, and environmental remediation. However, its utilization the cosmetic industry remains relatively underexplored. To address challenges associated with skin damage caused by preservatives thickeners used for extending shelf life of conventional products, a soothing lavender-scented electrospun fibrous eye mask coaxial layers was developed using electrospinning technique. Polyvinyl alcohol (PVA) served as hydrophilic outer sheath, while polycaprolactone (PCL) constituted hydrophobic core, lavender oil (LO) encapsulated within. The structural physicochemical properties samples were characterized scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), contact angle measurements. Upon hydration, membrane exhibited strong adhesion properties, notable antioxidant activity, degree antibacterial efficacy, demonstrating potential safe effective use skincare applications. These findings suggest that material offers promising functional integration into formulations.

Language: Английский

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Micro robot as the feature of robotic in healthcare approach from design to application: the State of art and challenges

EAI Endorsed Transactions on AI and Robotics, Journal Year: 2024, Volume and Issue: 3

Published: April 12, 2024

Micro robots, miniature robotic devices typically ranging from micrometers to a few millimeters in size, hold immense potential various fields, particularly healthcare. Their diminutive stature enables access intricate anatomical regions previously unreachable, facilitating targeted drug delivery, localized treatment, and precise monitoring. These robots offer numerous advantages, including enhanced maneuverability, reduced invasiveness, minimized tissue damage. By navigating through complex biological environments, micro can deliver therapies with unprecedented precision, improving treatment efficacy patient outcomes. Additionally, their small size allows for minimally invasive procedures, reducing recovery times enhancing comfort. Overall, represent groundbreaking technological advancement the revolutionize healthcare delivery significantly benefit human well-being.Their Despite challenges like constraints navigation complexities, innovative solutions interdisciplinary collaboration are driving

Language: Английский

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The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 11, 2025

The dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment prevention of still pose significant challenges. Within oral cavity, traditional drug delivery systems suffer from limitation such as inadequate tissue penetration, short duration action at target site, low specificity, which minimally affect caries. Consequently, nanosystem for delivery, offering enhanced stability, solubility, bio-availability while reducing side effects, garnering attention increasing fight against Therefore, this review examines role nanosystems combating by inhibiting bacteria survival, biofilm formation, demineralization, promoting remineralization, exploring their potential become mainstream means future.

Language: Английский

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Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1

Bio-Design and Manufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Non-invasive neuromodulation assisted by exogenous stimuli-responsive nanoplatforms for Alzheimer’s disease and Parkinson's disease therapy

The Innovation Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100121 - 100121

Published: Jan. 1, 2025

<p>In recent decades, the incidence of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s (PD) has risen continuously, significantly impairing patients’ quality life while imposing growing economic social burdens. Traditional treatments exhibit limited effectiveness in halting progression. Non-invasive neuromodulation techniques, utilizing electromagnetic fields, light, or ultrasound, have emerged promising strategies to modulate neural activity alleviate symptoms. However, achieving spatially precise targeted remains challenging. The integration stimuli-responsive nanoplatforms addresses this limitation. These nanoplatforms, engineered respond specific stimuli, can deliver therapeutic agents desired brain regions. By enabling controlled localized drug release, they facilitate neuromodulation. Despite their potential, several hurdles must be overcome, including optimization nanoplatform design, elucidating complex nanoplatform-brain interactions, ensuring long-term safety efficacy. Nonetheless, combining non-invasive with holds revolutionary potential for therapy, offering targeted, personalized that may halt slow This comprehensive review explores applications assisted by exogenous AD PD therapy.</p>

Language: Английский

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Intranasal liposomes co-delivery of Aβ-targeted KLVFF and ROS-responsive ceria for synergistic therapy of Alzheimer’s disease

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153210 - 153210

Published: June 16, 2024

β-Amyloid (Aβ) aggregation and oxidative stress are primary pathological features of Alzheimer's disease (AD). Combination therapies that target brain tissue corporately address these main factors required for effective AD treatment. Here, we developed a multifunctional liposome delivery system (KLVFF@LIP-CeO2) co-delivery Aβ-targeted KLVFF reactive oxygen species (ROS)-responsive Ceria (CeO2) through intranasal administration. After Aβ1-42-induced ROS apoptosis in HT22 cells, KLVFF@LIP-CeO2 exhibited significant protective effects by inhibiting Aβ scavenging multi-ROS. With features, verified the therapeutic effectiveness APPswe/PSEN1dE9 (APP/PS1) model mice. administration, demonstrated sufficient rapid accumulation significantly alleviated deposition stress, contributing to rescue cognitive impairment APP/PS1 These results highlight clinical potential multi-targeted nanoparticles synergistic therapy AD.

Language: Английский

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Aqueous Grown Quantum Dots with Robust Near-Infrared Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical Monitoring

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19038 - 19053

Published: July 9, 2024

Surgical intervention is the most common first-line treatment for severe traumatic brain injuries (TBIs) associated with high intracranial pressure, while complexity of these surgical procedures often results in complications. Surgeons struggle to comprehensively evaluate TBI status, making it difficult select optimal strategy. Here, we introduce a fluorescence imaging-based technology that uses high-quality silver indium selenide-based quantum dots (QDs) integrated diagnosis and guidance. These engineered, poly(ethylene glycol)-capped QDs emit near-infrared region, are resistant phagocytosis, importantly, ultrastable after epitaxial growth an aluminum-doped zinc sulfide shell aqueous phase renders long-term light irradiation complex physiological environments. We found intravenous injection enabled both precise mouse model and, more comprehensive evaluation status before, during, operation distinguish from superficial hemorrhages, provide real-time monitoring secondary hemorrhage, guide decision on evacuation hematomas. This QD-based diagnostic system could ultimately complement existing clinical tools treating TBI, which may help surgeons improve patient outcomes avoid unnecessary procedures.

Language: Английский

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