The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis
Huan Tian,
No information about this author
Dunbing Huang,
No information about this author
Jiaqi Wang
No information about this author
et al.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 29, 2024
Multiple
Sclerosis
(MS)
is
a
neurologic
autoimmune
disease
whose
exact
pathophysiologic
mechanisms
remain
to
be
elucidated.
Recent
studies
have
shown
that
the
onset
and
progression
of
MS
are
associated
with
dysbiosis
gut
microbiota.
Similarly,
large
body
evidence
suggests
mitochondrial
dysfunction
may
also
significant
impact
on
development
MS.
Endosymbiotic
theory
has
found
human
mitochondria
microbial
in
origin
share
similar
biological
characteristics
Therefore,
microbiota
function
crosstalk
relevant
However,
relationship
between
not
fully
understood.
by
synthesizing
previous
literature,
this
paper
focuses
changes
metabolite
composition
possible
MS,
provide
new
therapeutic
approaches
for
prevention
or
reduction
based
crosstalk.
Language: Английский
Body Composition and Its Outcomes and Management in Multiple Sclerosis: Narrative Review
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 1021 - 1021
Published: March 14, 2025
Background:
There
is
emerging
interest
in
obesity
and
its
prevalence,
outcomes,
management
people
with
multiple
sclerosis
(MS).
Body
mass
index
(BMI)
the
traditional
marker
of
MS,
whereas
body
composition,
inclusive
specific
tissue
compartments
(e.g.,
fat,
bone,
muscle),
often
overlooked
despite
relevance.
Objective:
This
narrative
review
(a)
underscored
use
utility
dual-energy
X-ray
absorptiometry
(DEXA)
as
an
accurate
reliable
measure
composition;
(b)
thematically
analyzed
synthesized
current
evidence
regarding
composition
(using
DEXA);
(c)
determined
gaps
to
be
addressed
future
research.
Methods:
The
structure
reporting
this
followed
guiding
criteria
outlined
Scale
for
Assessment
Narrative
Review
Articles
(SANRA).
relevant
literature
was
identified
via
a
PubMed
search
utilizing
combined
terms
such
‘body
composition’
‘multiple
sclerosis’.
research
then
organized
by
authors
into
major
themes
sub-themes.
articles
described
within
were
based
on
saturation
Results:
Three
identified,
namely
(1)
comparison
between
MS
non-MS
controls
(2
meta-analyses);
(2)
examination
relationships
range
outcomes
(14
cross-sectional
studies);
(3)
interventions
that
report
and/or
target
(11
clinical
trials).
Conclusions:
mapped
existing
posits
novel,
informative,
targeted
concept
population.
underscores
importance
randomized
controlled
trials
focus
significant
modifiable
outcome.
Such
could
improve
understanding
poor
identify
useful
recommendations
diagnosis
management.
Language: Английский
Fasting and Headache
Patrick T Ebbert,
No information about this author
Lauren R. Natbony
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Current Pain and Headache Reports,
Journal Year:
2025,
Volume and Issue:
29(1)
Published: March 21, 2025
Language: Английский
Research Roundup
Gillian Kamara,
No information about this author
Lisa Robson
No information about this author
British Journal of Neuroscience Nursing,
Journal Year:
2025,
Volume and Issue:
21(Sup 1a), P. S40 - S41
Published: March 1, 2025
Lisa
Robson
and
Gillian
Kamara
provide
a
synopsis
brief
review
of
selected
recently
published
research
articles
that
are
interest
to
neuroscience
nurses,
highlighting
key
points
keep
you
up
date;
full
reference
is
provided
so
the
can
be
read
in
Language: Английский
Intermittent fasting as a treatment for obesity in young people: a scoping review
npj Metabolic Health and Disease,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Dec. 30, 2024
Intermittent
fasting
focuses
on
the
timing
of
eating
rather
than
diet
quality
or
energy
intake,
with
evidence
supporting
its
effects
weight
loss
and
improvements
in
cardiometabolic
outcomes
adults
obesity.
However,
there
is
limited
for
feasibility
efficacy
young
people.
To
address
this,
a
scoping
review
was
conducted
to
examine
intermittent
regimens
individuals
aged
10
25
treatment
obesity
focusing
methodology,
intervention
parameters,
outcomes,
adherence,
feasibility,
efficacy.
Due
paucity
this
age
group,
adequately
assess
all
published
studies
category,
regardless
status
intention,
were
included
review.
The
34
(28
interventional
6
observational
studies)
893
participants
12
25.
Interventions
varied
9
cohorts
utilizing
as
an
treatment.
Thirteen
utilized
8-h
time-restricted
eating.
Primary
risk
factors
(7/28),
anthropometric
measurements
body
composition
(5/28),
muscular
performance
(4/28),
(1/28),
others
(4/28).
All
people
reported
some
degree
loss,
although
comparator
groups
significantly.
This
underscores
various
utilizations
group
highlights
potential
treating
findings
emphasize
need
rigorous
standardized
frameworks
ensure
comparability
determine
fasting's
practicality
depending
outcome
interest.
Language: Английский
Mind Over Microbes: Investigating the Interplay Between Lifestyle Factors, Gut Microbiota, and Brain Health
Neuroepidemiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: March 26, 2024
<b><i>Background:</i></b>
The
gut
microbiota
(GM)
of
the
human
body
comprises
several
species
microorganisms.
This
microorganism
plays
a
significant
role
in
physiological
and
pathophysiological
processes
various
diseases.
<b><i>Methods:</i></b>
literature
review
includes
studies
that
describe
causative
factors
influence
GM.
GM
is
sensitive
to
like
circadian
rhythms,
environmental
agents,
physical
activity,
nutrition,
hygiene
together
impact
functioning
composition
microbiome.
affects
health
host,
including
psycho-neural
aspects,
due
interconnectivity
between
brain
gut.
Hence,
this
paper
examines
relationship
with
neurodegenerative
disorders
context
these
aforesaid
factors.
<b><i>Conclusion:</i></b>
Future
identify
regulatory
pathways
associated
microbes
can
provide
causal
link
degeneration
at
molecular
level.
Together,
could
be
helpful
designing
preventive
treatment
strategies
aimed
GM,
so
diseases
treated.
Language: Английский
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus
Elliott Ferris,
No information about this author
Josue D. Gonzalez Murcia,
No information about this author
Adriana Cristina Rodriguez
No information about this author
et al.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 27, 2024
Abstract
Elucidating
the
genetic
basis
of
mammalian
metabolism
could
help
define
mechanisms
central
to
health
and
disease.
Here,
we
conserved
cis-
regulatory
elements
(CREs)
programs
for
metabolic
control.
We
delineate
gene
expression
chromatin
responses
in
mouse
hypothalamus
7
steps
Fed-to-Fasted-to-Refed
(FFR)
response
process.
Comparative
genomics
hibernating
versus
non-hibernating
lineages
then
illuminates
showing
convergent
changes
hibernators.
Hibernators
accumulated
loss-of-function
effects
specific
CREs
regulating
hypothalamic
FFR
responses.
Multi-omics
approaches
pinpoint
key
CREs,
genes,
programs,
cell
types
divergence
homeothermic
lineages.
The
refeeding
period
after
extended
fasting
is
revealed
as
one
critical
remodeling
with
genomic
changes.
This
framework
a
step
toward
harnessing
hibernator
adaptations
medicine.
One
sentence
summary
Convergent
signals
behind
food
scarcity
hibernator-homeotherm
divergence.
Language: Английский
Intermittent Fasting in Youth: A Scoping Review
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Intermittent
fasting
(IF)
focuses
on
the
timing
of
eating
rather
than
diet
quality
or
energy
intake,
with
evidence
supporting
its
effects
weight
loss
and
cardiometabolic
outcomes
in
adults.
However,
there
is
limited
for
efficacy
adolescents
emerging
To
address
this,
a
scoping
review
examined
IF
regimens
individuals
aged
10
to
25,
focusing
methodology,
intervention
parameters,
outcomes,
adherence,
feasibility,
efficacy.
The
included
39
studies
731
participants
15
25.
Methodologies
varied,
18
time-restricted
others
requiring
caloric
restriction.
Primary
risk
factors
(11/29),
body
composition
(9/29),
anthropometric
measurements
(8/29),
feasibility
(2/29).
Most
reported
significant
loss.
This
underscores
IF's
potential
treating
obesity
this
age
group
but
highlights
need
rigorous
standardized
frameworks
ensure
comparability
determine
practicality
group.
Language: Английский
Incidence and pattern of neurological emergencies in Ramadan
Rehab Magdy,
No information about this author
Demiana Adel Nagieb,
No information about this author
Rakia Mohamed
No information about this author
et al.
Nutritional Neuroscience,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 11
Published: Sept. 17, 2024
The
impact
of
Ramadan
fasting
on
various
neurological
emergencies
remains
relatively
unexplored.
This
study
aimed
to
clarify
the
incidence
and
pattern
different
in
compared
Shaaban.
Language: Английский