International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111695 - 111695
Published: Feb. 23, 2024
Language: Английский
Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14
Published: July 7, 2023
Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related death worldwide. Both genetic and environmental factors through a multitude underlying molecular mechanisms participate in pathogenesis HCC. Recently, numerous studies have shown that circular RNAs (circRNAs), an emerging class non-coding characterized by presence covalent bonds linking 3' 5' ends, play important role initiation progression cancers, including In this review, we outline current status field circRNAs, with emphasis on functions circRNAs HCC its microenvironment. We also summarize discuss recent advances as biomarkers therapeutic targets. These efforts are anticipated to throw new insights into future perspectives about basic, translational clinical research, eventually advancing diagnosis, prevention treatment
Language: Английский
Citations
8
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
The therapeutic potential of fucoidan (FUC), a natural polysaccharide, in metabolic disorders is recognized, yet its underlying mechanisms remain unclear. We conducted investigations into the FUC sourced from Sargassum fulvellum concerning induced by high-sucrose diet (HSD), employing Drosophila melanogaster and mice models. larvae were subjected to HSD exposure monitor growth inhibition, reduced pupation, developmental delays. Additionally, we examined impact on growth- development-related hormones Drosophila. Furthermore, assessed modulation larval intestinal homeostasis FUC, focusing regulation Notch signaling. In mice, evaluated effects HSD-induced impairments epithelial barrier integrity gut hormone secretion. supplementation significantly enhanced pupal weight effectively countered elevation glucose triglyceride levels. It notably influenced expression hormones, particularly augmenting insulin-like peptides production while mitigating retardation. also modulated negatively regulating signaling, thereby protecting against stress. ameliorated ileum Our findings demonstrate multifaceted maintaining health. holds promise as agent, with attributed partly sulfate group ability regulate emphasizing for addressing disorders.
Language: Английский
Citations
2
Metabolism, Journal Year: 2024, Volume and Issue: 164, P. 156104 - 156104
Published: Dec. 12, 2024
Language: Английский
Citations
2
Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 5070 - 5070
Published: Oct. 20, 2023
Pancreatic cancer (PCa) remains a formidable global health challenge, with high mortality rates and limited treatment options. While advancements in pharmacology have led to improved outcomes for various cancers, PCa continues exhibit significant disparities, disproportionately affecting certain populations. This paper explores the intersection of anthropology understanding disparities associated PCa. By considering socio-cultural, economic, behavioral factors that influence development, diagnosis, treatment, PCa, pharmacologic provides comprehensive framework address these improve patient care.
Language: Английский
Citations
6
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111695 - 111695
Published: Feb. 23, 2024
Language: Английский
Citations
2