Advanced Materials Technologies,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
3D
bioprinting
has
emerged
as
a
transformative
technology
in
tissue
engineering,
significantly
impacting
the
creation
of
patient‐specific
tissues
to
enhance
clinical
outcomes.
Despite
its
rapid
advancement,
translating
this
from
bench
bedside
remains
critical
need.
New
approaches,
such
handheld
printers
or
robotic
arm‐driven
situ
biofabrication
techniques,
have
promising
alternatives.
These
advancements
enable
reconstruction
damaged
directly
on
living
anatomical
structures,
offering
adaptability
and
precise
matching
affected
area.
The
integration
biomaterials,
engineering
principles,
digital
technologies,
particularly
robotics,
garnered
substantial
interest
both
academic
industrial
sectors,
highlighting
potential
for
applications.
However,
challenges
persist,
including
refining
bioink
formulations,
adjusting
mechanical
properties,
facilitating
crosslinking,
accurately
mimicking
extracellular
matrix.
This
review
explores
cutting‐edge
frontier
regeneration,
utilizing
arm‐assisted
printers.
It
systematically
examines
relative
advantages,
disadvantages,
challenges,
prospects
it
transitions
side
bed
side.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(12)
Published: Feb. 19, 2023
Three-dimensional
(3D)
bioprinting
technology
offers
great
potential
in
the
treatment
of
tissue
and
organ
damage.
Conventional
approaches
generally
rely
on
a
large
form
factor
desktop
bioprinter
to
create
vitro
3D
living
constructs
before
introducing
them
into
patient's
body,
which
poses
several
drawbacks
such
as
surface
mismatches,
structure
damage,
high
contamination
along
with
injury
due
transport
open-field
surgery.
In
situ
inside
body
is
potentially
transformational
solution
serves
an
excellent
bioreactor.
This
work
introduces
multifunctional
flexible
(F3DB),
features
degree
freedom
soft
printing
head
integrated
robotic
arm
deliver
multilayered
biomaterials
internal
organs/tissues.
The
device
has
master-slave
architecture
operated
by
kinematic
inversion
model
learning-based
controllers.
capabilities
different
patterns,
surfaces,
colon
phantom
are
also
tested
composite
hydrogels
biomaterials.
F3DB
capability
perform
endoscopic
surgery
further
demonstrated
fresh
porcine
tissue.
new
system
expected
bridge
gap
field
support
future
development
advanced
surgical
robots.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 101014 - 101014
Published: Feb. 29, 2024
Traditional
hydrogel
design
and
optimization
methods
usually
rely
on
repeated
experiments,
which
is
time-consuming
expensive,
resulting
in
a
slow-moving
of
advanced
development.
With
the
rapid
development
artificial
intelligence
(AI)
technology
increasing
material
data,
AI-energized
hydrogels
for
biomedical
applications
has
emerged
as
revolutionary
breakthrough
materials
science.
This
review
begins
by
outlining
history
AI
potential
advantages
using
hydrogels,
such
prediction
properties,
multi-attribute
optimization,
high-throughput
screening,
automated
discovery,
optimizing
experimental
design,
etc.
Then,
we
focus
various
supported
biomedicine,
including
drug
delivery,
bio-inks
manufacturing,
tissue
repair,
biosensors,
so
to
provide
clear
comprehensive
understanding
researchers
this
field.
Finally,
discuss
future
directions
prospects,
new
perspective
research
novel
applications.
Small,
Journal Year:
2024,
Volume and Issue:
20(22)
Published: Jan. 7, 2024
Abstract
Minimally
invasive
procedures
assisted
by
soft
robots
for
surgery,
diagnostics,
and
drug
delivery
have
unprecedented
benefits
over
traditional
solutions
from
both
patient
surgeon
perspectives.
However,
the
translation
of
such
technology
into
commercialization
remains
challenging.
The
lack
perception
abilities
is
one
obstructive
factors
paramount
a
safe,
accurate
efficient
robot‐assisted
intervention.
Integrating
different
types
miniature
sensors
onto
robotic
end‐effectors
promising
trend
to
compensate
perceptual
deficiencies
in
robots.
For
example,
haptic
feedback
with
force
helps
surgeons
control
interaction
at
tool‐tissue
interface,
impedance
sensing
tissue
electrical
properties
can
be
used
tumor
detection.
last
decade
has
witnessed
significant
progress
development
multimodal
built
on
advancement
engineering,
material
science
scalable
micromachining
technologies.
This
review
article
provides
snapshot
common
integrated
medical
It
covers
various
mechanisms,
examples
practical
clinical
applications,
standard
manufacturing
processes,
as
well
insights
emerging
engineering
routes
fabrication
novel
high‐performing
devices.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(6), P. 531 - 531
Published: March 16, 2024
Biomimetic
scaffolds
imitate
native
tissue
and
can
take
a
multidimensional
form.
They
are
biocompatible
influence
cellular
metabolism,
making
them
attractive
bioengineering
platforms.
The
use
of
biomimetic
adds
complexity
to
traditional
cell
cultivation
methods.
most
commonly
used
technique
involves
cultivating
cells
on
flat
surface
in
two-dimensional
format
due
its
simplicity.
A
three-dimensional
(3D)
provide
microenvironment
for
surrounding
cells.
There
two
main
techniques
obtaining
3D
structures
based
the
presence
scaffolding.
Scaffold-free
consist
spheroid
technologies.
Meanwhile,
scaffold
contain
organoids
all
constructs
that
various
types
scaffolds,
ranging
from
decellularized
extracellular
matrix
(dECM)
through
hydrogels
one
extensively
studied
forms
potential
culture
up
4D
bioprinted
biomaterials.
bioprinting
is
important
create
scaffolds.
versatility
this
allows
many
different
inks,
mainly
hydrogels,
as
well
inorganic
substances.
Increasing
amounts
data
evidence
vast
usage
engineering
personalized
medicine,
with
area
application
being
regeneration
skin
musculoskeletal
systems.
Recent
papers
also
indicate
increasing
vivo
tests
products
which
further
strengthen
importance
branch
emphasize
need
extensive
research
safe
humansbiomimetic
tissues
organs.
In
review
article,
we
recent
advancements
field
preceded
by
an
overview
technologies
led
development
complex
type
culture.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(20), P. 11585 - 11636
Published: Oct. 11, 2024
Soft
robotics
presents
innovative
solutions
across
different
scales.
The
flexibility
and
mechanical
characteristics
of
soft
robots
make
them
particularly
appealing
for
wearable
implantable
applications.
scale
level
invasiveness
required
depend
on
the
extent
human
interaction.
This
review
provides
a
comprehensive
overview
robots,
including
applications
in
rehabilitation,
assistance,
organ
simulation,
surgical
tools,
therapy.
We
discuss
challenges
such
as
complexity
fabrication
processes,
integration
responsive
materials,
need
robust
control
strategies,
while
focusing
advances
actuation
sensing
mechanisms,
techniques.
Finally,
we
future
outlook,
highlighting
key
proposing
potential
solutions.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(3), P. 032006 - 032006
Published: May 2, 2024
Abstract
Organoids
have
emerged
as
crucial
platforms
in
tissue
engineering
and
regenerative
medicine
but
confront
challenges
faithfully
mimicking
native
structures
functions.
Bioprinting
technologies
offer
a
significant
advancement,
especially
when
combined
with
organoid
bioinks-engineered
formulations
designed
to
encapsulate
both
the
architectural
functional
elements
of
specific
tissues.
This
review
provides
rigorous,
focused
examination
evolution
impact
bioprinting.
It
emphasizes
role
bioinks
that
integrate
key
cellular
components
microenvironmental
cues
more
accurately
replicate
complexity.
Furthermore,
this
anticipates
transformative
landscape
invigorated
by
integration
artificial
intelligence
bioprinting
techniques.
Such
fusion
promises
refine
bioink
optimize
parameters,
thus
catalyzing
unprecedented
advancements
medicine.
In
summary,
accentuates
pivotal
potential
advancing
therapies,
deepening
our
understanding
organ
development,
clarifying
disease
mechanisms.
Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Organ
damage
or
failure
arising
from
injury,
disease,
and
aging
poses
challenges
due
to
the
body's
limited
regenerative
capabilities.
transplantation
presents
issues
of
donor
shortages
immune
rejection
risks,
necessitating
innovative
solutions.
The
3D
bioprinting
organs
on
demand
offers
promise
in
tissue
engineering
medicine.
In
this
review,
we
explore
state-of-the-art
technologies,
with
a
focus
bioink
cell
type
selections.
We
follow
discussions
advances
solid
organs,
such
as
heart,
liver,
kidney,
pancreas,
highlighting
importance
vascularization
integration.
Finally,
provide
insights
into
key
future
directions
context
clinical
translation
bioprinted
their
large-scale
production.
Biophysics Reviews,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: July 19, 2024
3D
bioprinting
techniques
enable
the
precise
deposition
of
living
cells,
biomaterials,
and
biomolecules,
emerging
as
a
promising
approach
for
engineering
functional
tissues
organs.
Meanwhile,
recent
advances
in
researchers
to
build
vitro
models
with
finely
controlled
complex
micro-architecture
drug
screening
disease
modeling.
Recently,
artificial
intelligence
(AI)
has
been
applied
different
stages
bioprinting,
including
medical
image
reconstruction,
bioink
selection,
printing
process,
both
classical
AI
machine
learning
approaches.
The
ability
handle
datasets,
make
computations,
learn
from
past
experiences,
optimize
processes
dynamically
makes
it
an
invaluable
tool
advancing
bioprinting.
review
highlights
current
integration
discusses
future
approaches
harness
synergistic
capabilities
developing
personalized
