Toxicity Mechanisms of Microplastic and Its Effects on Ruminant Production: A Review DOI Creative Commons

Mao-Sen Su,

Shangquan Gan, Rui Gao

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 462 - 462

Published: March 21, 2025

Plastic pollution has become one of the major environmental problems facing human beings in world today. waste accumulated environment forms plastic particles different sizes due to farming activities, climate change, ultraviolet light, microbial degradation, and animal chewing. The caused by microplastics a problem recent years, it is also research hotspot field ecological environment. More more studies have found that ruminants are exposed for long time, which seriously threaten their healthy growth. This paper introduces current situation pollution; properties effects on environment, beings, animals; summarizes types toxicity mechanisms microplastics; concludes main ways enter harm them. In addition, shortcomings future development summarized prospected provide theoretical reference related alleviating influence ruminant production.

Language: Английский

Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) DOI
Sheng Liu, Chenyang Wang, Yunxiao Yang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133855 - 133855

Published: Feb. 21, 2024

Language: Английский

Citations

84
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies DOI

Zhengguo Liu,

Xue‐yi You

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166766 - 166766

Published: Sept. 2, 2023

Language: Английский

Citations

73
Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO DOI Creative Commons
Bo Wang,

Boxuan Liang,

Yuji Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 5, 2023

Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis M1‐macrophage aorta, manifesting as upregulation macrophage receptor collagenous structure (MARCO). Moreover, disrupt lipid metabolism increase long‐chain acyl carnitines (LCACs). LCAC accumulation attributed PS‐NP‐inhibited hepatic carnitine palmitoyltransferase 2. PS‐NPs, well LCACs alone, aggravate via upregulating MARCO oxidized low‐density lipoprotein‐activated foam cells. Finally, synergistic effects on increasing total cholesterol cells found. Overall, study indicates PS‐NP‐induced atherosclerosis MARCO. This offers new insight into mechanisms MNP‐induced cardiovascular toxicity, highlights combined endogenous metabolites system, which warrant further study.

Language: Английский

Citations

49
Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo DOI Creative Commons

Yuji Huang,

Boxuan Liang,

Zhiming Li

et al.

Particle and Fibre Toxicology, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 22, 2023

Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.

Language: Английский

Citations

46
Micro/nano-plastics impacts in cardiovascular systems across species DOI
Ji Liang, Feng Ji,

Anisah Lee Binti Abdullah

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 942, P. 173770 - 173770

Published: June 7, 2024

Language: Английский

Citations

22
Micro-nanoplastics and cardiovascular diseases: evidence and perspectives DOI Creative Commons
Francesco Prattichizzo, Antonio Ceriello, Valeria Pellegrini

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(38), P. 4099 - 4110

Published: Sept. 6, 2024

Abstract Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent suggests micro- and nanoplastic (MNP) particles derived largely from or mechanical degradation plastics might represent a novel CVD risk factor. Experimental data preclinical models suggest MNPs can foster oxidative stress, platelet aggregation, cell senescence, inflammatory responses endothelial immune cells while promoting range metabolic alterations lead to disease premature death. In humans, various plastics, including polyethylene polyvinylchloride, have been detected atherosclerotic plaques other tissues, pericardia, epicardial adipose pericardial myocardia, left atrial appendages. measurable levels within thrombi seem accumulate preferentially areas vascular lesions. Their presence carotid is associated with subsequent increased incidence events. To further investigate possible causal role CVD, future studies should focus on large, prospective cohorts assessing exposure individuals plastic-related pollution, routes absorption, existence putative safety limit, correspondence between accumulation timing development, pathophysiological mechanisms instigated by pertinent concentrations MNPs. Data such would allow design preventive, even therapeutic, strategies. Meanwhile, existing reducing plastic production use will produce benefits for human health. This goal could be achieved through UN Global Plastics Treaty currently negotiation.

Language: Английский

Citations

19
Microplastics in Animal-Derived Products and Their Potential Risks to Human Health DOI
Hao Zeng, Yujie Cui,

Runlin Shao

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118187 - 118187

Published: Feb. 1, 2025

Language: Английский

Citations

3
Surface-Charge-Driven Ferroptosis and Mitochondrial Dysfunction Is Involved in Toxicity Diversity in the Marine Bivalve Exposed to Nanoplastics DOI
Yanfei Zhou, Wenzhi Liu, Hao Jiang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2370 - 2383

Published: Jan. 8, 2024

Nanoplastics (NPs) pervade daily life, posing serious threats to marine ecosystems. Despite the crucial role that surface charge plays in NP effects, there is a substantial gap our understanding of how influences toxicity. Herein, by exposing

Language: Английский

Citations

18
Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish DOI Creative Commons
Rongyi Ye, Zhiming Li,

Hongyi Xian

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(2)

Published: Feb. 1, 2024

Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.

Language: Английский

Citations

16
Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk DOI Creative Commons
Junjie Fan, Li Liu, Yongling Lu

et al.

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 12, 2024

Abstract Background The global use of plastic materials has undergone rapid expansion, resulting in the substantial generation degraded and synthetic microplastics nanoplastics (MNPs), which have potential to impose significant environmental burdens cause harmful effects on living organisms. Despite this, detrimental impacts MNPs exposure towards host cells tissues not been thoroughly characterized. Results In present study, we elucidated a previously unidentified hepatotoxic effect 20 nm polystyrene nanoparticles (PSNPs), rather than larger PS beads, by selectively inducing necroptosis macrophages. Mechanistically, PSNPs were rapidly internalized macrophages accumulated mitochondria, where they disrupted mitochondrial integrity, leading heightened production reactive oxygen species (mtROS). This elevated mtROS essentially triggered macrophages, enhanced crosstalk with hepatocytes, ultimately hepatocyte damage. Additionally, it was demonstrated that induced promoted acute liver injury mice. significantly mitigated administration inhibitor or systemic depletion prior injection. Conclusion Collectively, our study suggests profound toxicity PSNP triggering macrophage necroptosis, turn induces hepatotoxicity via intercellular between hepatocytes hepatic microenvironment.

Language: Английский

Citations

14