Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 462 - 462
Published: March 21, 2025
Plastic
pollution
has
become
one
of
the
major
environmental
problems
facing
human
beings
in
world
today.
waste
accumulated
environment
forms
plastic
particles
different
sizes
due
to
farming
activities,
climate
change,
ultraviolet
light,
microbial
degradation,
and
animal
chewing.
The
caused
by
microplastics
a
problem
recent
years,
it
is
also
research
hotspot
field
ecological
environment.
More
more
studies
have
found
that
ruminants
are
exposed
for
long
time,
which
seriously
threaten
their
healthy
growth.
This
paper
introduces
current
situation
pollution;
properties
effects
on
environment,
beings,
animals;
summarizes
types
toxicity
mechanisms
microplastics;
concludes
main
ways
enter
harm
them.
In
addition,
shortcomings
future
development
summarized
prospected
provide
theoretical
reference
related
alleviating
influence
ruminant
production.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(19)
Published: May 5, 2023
Abstract
Exposure
to
micro‐
and
nanoplastics
(MNPs)
is
common
because
of
their
omnipresence
in
environment.
Recent
studies
have
revealed
that
MNPs
may
cause
atherosclerosis,
but
the
underlying
mechanism
remains
unclear.
To
address
this
bottleneck,
ApoE
−/−
mice
are
exposed
2.5–250
mg
kg
−1
polystyrene
(PS‐NPs,
50
nm)
by
oral
gavage
with
a
high‐fat
diet
for
19
weeks.
It
found
PS‐NPs
blood
aorta
mouse
exacerbate
artery
stiffness
promote
atherosclerotic
plaque
formation.
activate
phagocytosis
M1‐macrophage
aorta,
manifesting
as
upregulation
macrophage
receptor
collagenous
structure
(MARCO).
Moreover,
disrupt
lipid
metabolism
increase
long‐chain
acyl
carnitines
(LCACs).
LCAC
accumulation
attributed
PS‐NP‐inhibited
hepatic
carnitine
palmitoyltransferase
2.
PS‐NPs,
well
LCACs
alone,
aggravate
via
upregulating
MARCO
oxidized
low‐density
lipoprotein‐activated
foam
cells.
Finally,
synergistic
effects
on
increasing
total
cholesterol
cells
found.
Overall,
study
indicates
PS‐NP‐induced
atherosclerosis
MARCO.
This
offers
new
insight
into
mechanisms
MNP‐induced
cardiovascular
toxicity,
highlights
combined
endogenous
metabolites
system,
which
warrant
further
study.
Particle and Fibre Toxicology,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Nov. 22, 2023
Microplastics
and
nanoplastics
(MNPs)
are
emerging
environmental
contaminants
detected
in
human
samples,
have
raised
concerns
regarding
their
potential
risks
to
health,
particularly
neurotoxicity.
This
study
aimed
investigate
the
deleterious
effects
of
polystyrene
(PS-NPs,
50
nm)
understand
mechanisms
inducing
Parkinson's
disease
(PD)-like
neurodegeneration,
along
with
exploring
preventive
strategies.
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
45(38), P. 4099 - 4110
Published: Sept. 6, 2024
Abstract
Emerging
evidence
indicates
that
chemical
exposures
in
the
environment
are
overlooked
drivers
of
cardiovascular
diseases
(CVD).
Recent
suggests
micro-
and
nanoplastic
(MNP)
particles
derived
largely
from
or
mechanical
degradation
plastics
might
represent
a
novel
CVD
risk
factor.
Experimental
data
preclinical
models
suggest
MNPs
can
foster
oxidative
stress,
platelet
aggregation,
cell
senescence,
inflammatory
responses
endothelial
immune
cells
while
promoting
range
metabolic
alterations
lead
to
disease
premature
death.
In
humans,
various
plastics,
including
polyethylene
polyvinylchloride,
have
been
detected
atherosclerotic
plaques
other
tissues,
pericardia,
epicardial
adipose
pericardial
myocardia,
left
atrial
appendages.
measurable
levels
within
thrombi
seem
accumulate
preferentially
areas
vascular
lesions.
Their
presence
carotid
is
associated
with
subsequent
increased
incidence
events.
To
further
investigate
possible
causal
role
CVD,
future
studies
should
focus
on
large,
prospective
cohorts
assessing
exposure
individuals
plastic-related
pollution,
routes
absorption,
existence
putative
safety
limit,
correspondence
between
accumulation
timing
development,
pathophysiological
mechanisms
instigated
by
pertinent
concentrations
MNPs.
Data
such
would
allow
design
preventive,
even
therapeutic,
strategies.
Meanwhile,
existing
reducing
plastic
production
use
will
produce
benefits
for
human
health.
This
goal
could
be
achieved
through
UN
Global
Plastics
Treaty
currently
negotiation.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(3), P. 2370 - 2383
Published: Jan. 8, 2024
Nanoplastics
(NPs)
pervade
daily
life,
posing
serious
threats
to
marine
ecosystems.
Despite
the
crucial
role
that
surface
charge
plays
in
NP
effects,
there
is
a
substantial
gap
our
understanding
of
how
influences
toxicity.
Herein,
by
exposing
Environmental Health Perspectives,
Journal Year:
2024,
Volume and Issue:
132(2)
Published: Feb. 1, 2024
Micro-
and
nanoplastics
(MNPs)
homosalate
(HMS)
are
ubiquitous
emerging
environmental
contaminants
detected
in
human
samples.
Despite
the
well-established
endocrine-disrupting
effects
(EDEs)
of
HMS,
interaction
between
MNPs
HMS
its
impact
on
HMS-induced
EDEs
remain
unclear.
Particle and Fibre Toxicology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: April 12, 2024
Abstract
Background
The
global
use
of
plastic
materials
has
undergone
rapid
expansion,
resulting
in
the
substantial
generation
degraded
and
synthetic
microplastics
nanoplastics
(MNPs),
which
have
potential
to
impose
significant
environmental
burdens
cause
harmful
effects
on
living
organisms.
Despite
this,
detrimental
impacts
MNPs
exposure
towards
host
cells
tissues
not
been
thoroughly
characterized.
Results
In
present
study,
we
elucidated
a
previously
unidentified
hepatotoxic
effect
20
nm
polystyrene
nanoparticles
(PSNPs),
rather
than
larger
PS
beads,
by
selectively
inducing
necroptosis
macrophages.
Mechanistically,
PSNPs
were
rapidly
internalized
macrophages
accumulated
mitochondria,
where
they
disrupted
mitochondrial
integrity,
leading
heightened
production
reactive
oxygen
species
(mtROS).
This
elevated
mtROS
essentially
triggered
macrophages,
enhanced
crosstalk
with
hepatocytes,
ultimately
hepatocyte
damage.
Additionally,
it
was
demonstrated
that
induced
promoted
acute
liver
injury
mice.
significantly
mitigated
administration
inhibitor
or
systemic
depletion
prior
injection.
Conclusion
Collectively,
our
study
suggests
profound
toxicity
PSNP
triggering
macrophage
necroptosis,
turn
induces
hepatotoxicity
via
intercellular
between
hepatocytes
hepatic
microenvironment.