International Journal of Endocrinology,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Endocrine-disrupting
chemicals
(EDCs),
found
in
various
cosmetic
products,
interfere
with
the
normal
functioning
of
endocrine
system,
impacting
hormone
regulation
and
posing
risks
to
human
health.
Common
EDCs,
such
as
ultraviolet
(UV)
filters,
parabens,
triclosan,
can
enter
body
through
different
routes,
including
skin
absorption.
Their
presence
has
been
linked
adverse
effects
on
reproduction,
immune
function,
development.
High-throughput
vitro
assays,
using
cell
lines,
were
employed
assess
common
EDCs
ethylhexyl
methoxycinnamate
(EHMC),
benzophenone-3
(BP-3),
homosalate,
parabens.
Despite
ongoing
regulatory
efforts,
gaps
persist
understanding
their
long-term
impacts,
particularly
when
they
are
present
mixtures
or
degradation
products
environment.
This
study
focuses
recent
research
investigate
mechanisms
which
cosmetic-related
disrupt
system
other
physiological
systems.
The
findings
highlight
broader
systemic
impact
these
chemicals,
extending
beyond
include
immune,
reproductive,
cardiovascular
effects.
underscores
importance
developing
safer
formulations
enhancing
public
health
protection,
emphasizing
need
for
stricter
regulations.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(35), P. 24044 - 24059
Published: Aug. 19, 2024
Oral
ingestion
is
the
primary
route
for
human
exposure
to
nanoplastics,
making
gastrointestinal
tract
one
of
first
and
most
impacted
organs.
Given
presence
gut–brain
axis,
a
crucial
concern
arises
regarding
potential
impact
intestinal
damage
on
neurotoxic
effects
nanoplastics
(NPs).
The
intricate
mechanisms
underlying
NP-induced
neurotoxicity
through
microbiome–gut–brain
axis
necessitate
further
investigation.
To
address
this,
we
used
mice
specifically
engineered
with
nuclear
factor
erythroid-derived
2-related
2
(Nrf2)
deficiency
in
their
intestines,
strain
whose
intestines
are
particularly
susceptible
polystyrene
NPs
(PS-NPs).
We
conducted
28-day
repeated-dose
oral
toxicity
study
2.5
250
mg/kg
50
nm
PS-NPs
these
mice.
Our
delineated
how
PS-NP
caused
gut
microbiota
dysbiosis,
characterized
by
Mycoplasma
Coriobacteriaceae
proliferation,
resulting
increased
levels
interleukin
17C
(IL-17C)
production
intestines.
surplus
IL-17C
permeated
brain
via
bloodstream,
triggering
inflammation
damage.
investigation
elucidated
direct
correlation
between
health
neurological
outcomes
context
exposure.
Susceptible
fragile
guts
exhibited
heightened
induced
PS-NPs.
This
phenomenon
was
attributed
elevated
abundance
associated
mice,
such
as
Mesorhizobium
Lwoffii,
provoked
Neurotoxicity
alleviated
vivo
treatment
anti-IL-17C-neutralizing
antibodies
or
antibiotics.
These
findings
advanced
our
comprehension
regulatory
governing
PS-NP-induced
underscored
critical
importance
maintaining
mitigate
Environment & Health,
Journal Year:
2024,
Volume and Issue:
2(7), P. 424 - 440
Published: May 4, 2024
Triclosan
(TCS)
has
garnered
significant
attention
due
to
its
widespread
use
and
associated
endocrine-disrupting
effects.
However,
impact
on
the
neuroendocrine
system
underlying
mechanisms
remain
poorly
understood.
Here,
we
established
correlations
between
TCS
exposure
serum
sex
hormone
levels
in
participants
of
National
Health
Nutrition
Examination
Survey
(NHANES).
Additionally,
investigated
TCS's
influence
using
adult
zebrafish
exposed
environmentally
relevant
concentrations
(0.361–48.2
μg/L)
for
21
days.
Assessment
reproductive
neurotoxicity
included
histopathological
examination
behavioral
tests.
Transcriptomics,
proteomics
analyses,
biochemical
detection
were
employed
elucidate
TCS-induced
disruption.
Significant
found
estradiol,
testosterone,
hormone-binding
globulin
NHANES
participants.
In
addition,
inhibited
ovary
development
spermatogenesis
zebrafish.
Transcriptomics
analysis
revealed
gender-specific
key
signaling
metabolism-related
pathways
implicated
toxicity.
Moreover,
induced
nervous
impairment,
as
evidenced
by
histological
changes
altered
motor
behavior,
possibly
with
oxidative
damage.
Correlation
further
highlighted
potential
connection
endocrine
disruption
impairment
following
exposure.
Overall,
this
study
provided
evidence
supporting
offered
insights
into
mechanisms.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 28, 2025
The
study
investigates
the
synergistic
endocrine
disruption
and
cellular
toxicity
resulting
from
co-exposure
to
polyethylene
microplastics
(PE-MPs)
bisphenol
A
(BPA)
in
zebrafish
MLTC-1
cells.
Previous
research
has
extensively
examined
individual
effects
of
PE-MPs
BPA
on
systems
health.
However,
specific
interactions
combined
toxicological
impacts
these
two
common
environmental
pollutants
remain
underexplored,
particularly
terms
their
pathways
viability.
To
fill
this
knowledge
gap,
we
characterized
using
scanning
electron
microscopy
Raman
spectrometry
exposed
cells
PE-MPs,
BPA,
or
combinations
both.
results
showed
that
100
µg/mL
100-150
µmol/L
for
48
h
significantly
decreased
cell
viability,
increased
apoptosis
rates,
induced
G2/M
cycle
arrest,
reduced
mitochondrial
membrane
potential,
altered
transcriptional
expression
genes
related
steroidogenesis.
Specifically,
upregulated
Ar
while
downregulating
Lhr
3β-Hsd,
with
being
more
pronounced
than
those
observed
single
exposures.
In
a
complementary
vivo
study,
adult
were
environmentally
relevant
concentrations
(1
mg/L)
(1.5
µg/L)
28
days.
This
resulted
significant
increases
GSI
alterations
gene
associated
HPG
axis.
male
brains,
such
as
Gnrh2,
Esr1,
downregulated,
female
Gnrh3,
also
exhibited
downregulation.
testes,
Star,
Cyp11a1,
Hsd11b2
upregulated,
whereas
Cyp19a1a,
Hsd3b,
Hsd20b,
Hsd17b3
downregulated.
contrast,
ovaries
upregulation
Cyp17,
Cyp11b,
Hsd17b3,
Cyp19a1a
was
indicating
sex-specific
disruption.
Overall,
findings
reveal
induces
toxic
both
vitro
vivo,
which
underscores
importance
studying
better
assess
health
risks.
Journal of Applied Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Abstract
Cumulative
evidence
suggested
that
nanoplastics
(NPs)
cause
male
toxicity,
but
the
mechanisms
of
which
are
still
misty.
Steroidogenesis
is
a
key
biological
event
responsible
for
maintaining
reproductive
health.
However,
whether
dysregulated
steroidogenesis
involved
in
NPs‐induced
impaired
function
and
underlying
mechanism
remains
unclear.
In
our
study,
Balb/c
mice
were
continuously
exposed
to
pristine‐NPs
or
NH
2
‐NPs
12
weeks,
spanning
puberty
adult
stage.
Upon
long‐term
NPs
treatment,
hypothalamus
testis
subjected
transcriptome
metabolome
analysis.
And
results
demonstrated
both
primitive‐NPs
resulted
spermatogenesis
steroidogenesis,
as
evidenced
by
significant
reduction
sperm
quality,
testosterone,
FSH,
LH.
The
expression
genes
hypothalamic‐pituitary‐testis
(HPT)
axis,
such
Kiss‐1
Cyp17a1
encoded
steroid
hormone
synthetase,
was
also
diminished.
Furthermore,
phosphatidylcholine
pantothenic
acid
mainly
enriched
glycerophospholipid
metabolism
significantly
reduced
testis.
Comprehensive
analysis
indicated
down‐regulated
associated
with
decreased
metabolites
acid.
Overall,
we
speculate
disturbed
HPT
axis
induced
contributes
disordered
subsequently
steroidogenesis.
Our
findings
deepen
understanding
action
toxicology.
