Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(22), P. 12371 - 12430

Published: Aug. 24, 2023

Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on photoresponsive materials have become a new trend in inactivation due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective promising strategy recent years. In process treatment, are excited by different wavelengths lights produce reactive oxygen species (ROS) or other toxic killing various microbes, such bacteria, viruses, fungi, parasites, algae. Therefore, this review timely summarizes latest progress PCAT field, with emphasis development antimicrobials (PCAMs), underlying mechanisms, design multiple practical applications local infections therapy, personal protective equipment, water purification, coatings, wound dressings, food safety, antibacterial textiles, air purification. Meanwhile, we also present challenges perspectives widespread implementation therapeutics. We hope result review, will flourish weapon against antibiotic

Language: Английский

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Flourishing Antibacterial Strategies for Osteomyelitis Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Jan. 30, 2023

Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because the complex and long‐term abnormal conditions, osteomyelitis one refractory diseases in orthopedics. Currently, anti‐infective therapy primary modality for addition to thorough surgical debridement. However, bacterial resistance has gradually reduced benefits traditional antibiotics, development advanced antibacterial agents received growing attention. This review introduces main targets treating osteomyelitis, including cell wall, membrane, intracellular macromolecules, energy metabolism, focuses on their mechanisms, predicts prospects clinical applications.

Language: Английский

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Antimicrobial Hydrogels: Potential Materials for Medical Application

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Sept. 26, 2023

Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.

Language: Английский

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Osteomyelitis and non-coding RNAS: A new dimension in disease understanding

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155186 - 155186

Published: Feb. 2, 2024

Language: Английский

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3D-printed bone scaffolds containing graphene oxide/gallium nanocomposites for dual functions of anti-infection and osteogenesis differentiation

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 57, P. 105770 - 105770

Published: Jan. 1, 2025

Language: Английский

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Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 100, P. 106617 - 106617

Published: Sept. 23, 2023

The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.

Language: Английский

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Lattice Strain Engineering of Ti₃C₂ Narrows Band Gap for Realizing Extraordinary Sonocatalytic Bacterial Killing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14840 - 14851

Published: July 26, 2023

The rapid development of sonodynamic therapy (SDT) provides a promising strategy for treating deep-seated multidrug-resistant (MDR) bacterial infection. However, the extreme scarcity biologically functional and highly efficient sonosensitizers severely limits further clinical practice SDT. Herein, lattice-strain-rich Ti3C2 (LS-Ti3C2) with greatly improved sonosensitizing effect is one-step synthesized using meso-tetra(4-carboxyphenyl)porphine (TCPP) by solvothermal method realizing extraordinary intervention TCPP causes all Ti–O chemical bonds most Ti–F on surface layer to break down. amino groups are then recombined these exposed Ti atoms perturb order atoms, resulting in displacement final lattice structural distortion Ti3C2. inherent strain narrows band gap Ti3C2, which mainly facilitates electron–hole pair separation electron transfer under ultrasound irradiation, thereby US-mediated reactive oxygen species (ROS) production subsequent robust bactericidal capability (99.77 ± 0.16%) against methicillin-resistant Staphylococcus aureus (MRSA). Overall, this research offers perspective into Ti-familial toward SDT practice.

Language: Английский

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Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 17, 2024

Abstract The effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, high probability recurrence, requirement secondary surgery or multiple surgeries, and in eradicating infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Hence, smart biodegradable biomaterials that provide precise local anti‐infection effects can promote repair defects are actively being developed. Here, a novel nano‐micro composite is fabricated combining calcium phosphate (CaP) nanosheets drug‐loaded GelMA microspheres via microfluidic technology. covalently linked vancomycin (Van) through an oligonucleotide (oligo) linker using EDC/NHS carboxyl activator. Accordingly, called “CaP@MS‐Oligo‐Van” synthesized. porous CaP@MS‐Oligo‐Van composites target capture bacteria. They also release Van response presence bacterial micrococcal nuclease Ca 2+ , exerting additional antibacterial inhibiting inflammatory response. Finally, released CaP tissue repair. Overall, findings show rapid, targeted drug system based on effectively infections. this agent holds potential clinical treatment MRSA.

Language: Английский

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Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13573 - 13584

Published: March 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Language: Английский

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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 14, 2024

Abstract This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance bone‐related applications. Various synthesis methods types 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, MXene are discussed, along strategies for incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical high surface area, strong near‐infrared (NIR) photon absorption controlled release capabilities, making them suitable range regeneration therapeutic In cancer therapy, 2D‐material‐based show promise photothermal photodynamic therapies, drug delivery (chemotherapy). The properties these materials enable selective tumor ablation upon NIR irradiation, while drug‐loading capacity facilitates targeted chemotherapeutic agents. Additionally, 2D‐materials ‐infused potent antibacterial activity, effective against multidrug‐resistant infections disruption biofilm generated implant surface. Moreover, synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, immunotherapy to enhance outcomes. bio‐imaging, serve versatile contrast agents imaging probes, enabling real‐time monitoring during imaging. Furthermore, bone regeneration, most incorporated promote osteogenesis tissue offering potential solutions defects repair. Overall, integration presents promising platform developing multifunctional theragenerative biomaterials.

Language: Английский

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