Herbal Medicine: Enhancing the Anticancer Potential of Natural Products in Hepatocellular Carcinoma Therapy Through Advanced Drug Delivery Systems DOI Creative Commons
Ghazala Muteeb,

Manar T. El-Morsy,

Mustafa Ali Abo-Taleb

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 673 - 673

Published: May 20, 2025

Hepatocellular carcinoma (HCC) is an aggressive and prevalent liver cancer with a poor prognosis. Nanotechnology combined natural products has emerged as promising strategy to enhance HCC treatment efficacy. This review assesses the current literature on application of nanotechnology in delivering for therapy. A comprehensive search was conducted PubMed, Science Direct, Web Science, Google Scholar identify relevant studies published up present articles focusing nanotechnology-based drug delivery systems using therapy, including different nanoparticle (NP) formulations therapeutic interventions, were included. Natural anticancer properties have been encapsulated various nanocarriers such liposomes, polymeric nanoparticles, quantum dots, which improved stability, prolonged circulation time, enhanced targeted cells. These advancements led increased efficacy reduced side effects. Additionally, combining multiple or integrating them conventional therapies via enables personalized approaches based patient characteristics molecular profiles. The integration shows great potential improving outcomes, representing significant advancement precision medicine paving way more effective strategies.

Language: Английский

A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma DOI Creative Commons
Ying Wen, Jing Ning, Min Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(8)

Published: Jan. 18, 2023

Abstract Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains significant challenge due complex physical environment. Human carboxylesterase (CE) is expected be potential of hepatocellular carcinoma (HCC) improve the accuracy diagnosis. However, existing probes CE has slow response rate low selectivity. Herein, amide group selected as CE‐responsive sites based on “substrate‐hydrolysis enzymatic reaction” approach. From series off–on with leave groups in unit, probe J screened optimal combination rapid high selectivity toward CE. requires only 150 s reach maximum at 676 nm presence free from interference other esterase. Computational docking simulations indicate shortest distance between active site . Cell vivo present that can turn liver cancer cells tumor region precisely. Importantly, allowed specifically image orthotopic rather than metastatic distinguish human primary tissue adjacent ones. This study provides new tool detection promotes advancements accurate HCC

Language: Английский

Citations

46
ONOO–-activatable and LD-traced NIR fluorescent probe for mechanism study and early diagnosis of NAFLD and diabetes induced liver injury DOI

Nannan Wang,

Xiaoyan Lu, Jiamin Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135806 - 135806

Published: April 10, 2024

Language: Английский

Citations

35
Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries DOI
Yang Shen, Wei Li, Zhixuan Zhou

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(32)

Published: May 23, 2024

Clear delineation of tumor margins is essential for accurate resection and decreased recurrence rate in the clinic. Fluorescence imaging emerging as a promising alternative to traditional visual inspection by surgeons intraoperative imaging. However, probes lack accuracy diagnosis, making it difficult depict boundaries accurately. Herein, we proposed an offensive defensive integration (ODI) strategy based on "attack systems (invasive peptidase) defense (reductive microenvironment)" multi-dimensional characteristics design activatable fluorescent precisely. Screened out from series ODI strategy-based probes, ANQ performed better than unilateral correlation distinguishing between cells normal minimizing false-positive signals living metabolic organs. To further improve signal-to-background ratio vivo, derivatized FANQ, was prepared successfully applied distinguish orthotopic hepatocellular carcinoma tissues adjacent mice models clinical samples. This work highlights innovative develop rapid diagnosis tumors high-precision boundaries, providing more efficient tools future applications assisted resection.

Language: Английский

Citations

22
Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges DOI Creative Commons
Luling Wu, Zilu Li, Kun Wang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Liver disease poses a significant challenge to global health, and its early diagnosis is crucial for improving treatment outcomes patient prognosis. Since fluctuation of key biomarkers during the onset progression liver diseases can directly reflect health normal/abnormal function, biomarker-based assays are vital tools detection disease. In this context, small molecule fluorescent probes have undeniably emerged as indispensable analysis, with an ever-growing number molecule-based being developed over recent years, sole aim monitoring relevant This perspective will focus on development application primarily last 10 years diagnosing range disease-related processes. It outline foundational design strategies developing promising probes, their optical response biomarkers, how they been demonstrated in proof-of-concept imaging applications. Current challenges new developments field be discussed, providing insights highlighting opportunities field.

Language: Английский

Citations

4
THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores DOI Creative Commons
Zhiqiang Mao, Hyeonji Rha, Jungryun Kim

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 28, 2023

Near-infrared fluorescence imaging is vital for exploring the biological world. The short emissions (<650 nm) and small Stokes shifts (<30 of current xanthene dyes obstruct their applications since a long time. Recently, potent universal THQ structural modification technique that emission to NIR-I/II range enables substantial shift (>100 THQ-modified established. Thus, timely discussion THQ-xanthene its extensive. Hence, advent, working principles, development trajectory, dyes, especially in fields probe-based sensing imaging, cancer theranostics, super-resolution are introduced. It envisioned tactic simple yet exceptional approach upgrade performance conventional dyes. will advance strides xanthene-based potentials early fluorescent diagnosis diseases, imaging-guided surgery.

Language: Английский

Citations

40
Diketopyrrolopyrrole-based fluorescent probe for visualizing over-expressed carboxylesterase in fever via ratiometric imaging DOI
Bo Zhang,

Shuchun Qin,

Nannan Wang

et al.

Talanta, Journal Year: 2023, Volume and Issue: 266, P. 124971 - 124971

Published: July 19, 2023

Language: Английский

Citations

38
Recent advances in enzyme-activated NIR fluorescent probes for biological applications DOI
Hyunsun Jeong, Xiao‐Feng Wu, Jun‐Seok Lee

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 168, P. 117335 - 117335

Published: Sept. 27, 2023

Language: Английский

Citations

33
Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers DOI

Quan Wei,

Wenhui Song, Qian Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215407 - 215407

Published: Sept. 12, 2023

Language: Английский

Citations

31
Ketocyanine‐Based Fluorescent Probe Revealing the Polarity Heterogeneity of Lipid Droplets and Enabling Accurate Diagnosis of Hepatocellular Carcinoma DOI

Deming He,

Minmin Yan,

Qiuling Sun

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(7)

Published: Jan. 19, 2024

Hepatocellular carcinoma (HCC) has gradually become a pronoun for terrifying death owing to its high mortality rate. With the progression of HCC, lipid droplets (LDs) in HCC cells exhibit specific variations such as increased LDs number and decreased polarity, which can serve diagnostic target. However, developing an effective method achieve diagnosis reveal polarity heterogeneity is still crucial challenge. Herein, first high-performance LDs-targeting probe (1) reported based on ketocyanine strategy with ultrasensitive polarity-responding ability near-infrared emission. Probe 1 shows excellent sensitivity parameter Δf (0.027-0.290) 808-fold fluorescence enhancement emission wavelength red-shifts 91 nm. In cells, 2.5- 5.9-fold compared normal other cancer exceeds clinical threshold 2.0, indicating distinguish cells. The revealed it displays sequence, < may provide useful insight engineer probes cell discrimination. Finally, realizes accurate cellular, organ, vivo levels, providing satisfying tool surgical navigation.

Language: Английский

Citations

18
Co-Reactive Ligand In Situ Engineered Gold Nanoclusters with Ultra-Bright Near-Infrared Electrochemiluminescence for Ultrasensitive and Label-Free Detection of Carboxylesterase Activity DOI
Wenzheng Guo, Mingyang Xia, Peng Duan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(6), P. 2369 - 2377

Published: Feb. 4, 2024

Ultrasensitive and accurate monitoring of carboxylesterase (CE) activity is extremely crucial for the early diagnosis hepatocellular carcinoma (HCC), which still a considerable challenge. Herein, using co-reactive ligand engineering strategy, ultra-bright near-infrared (λmax = 830 nm) self-enhanced electrochemiluminescence (ECL) Au nanoclusters (NCs) were in situ prepared with 2-(diethylamino) ethanethiol (DEAET) as ligand. Remarkably, not only acts stabilizer like traditional ligands but also plays role co-reactant to ensure confinement effect shorten charge transfer distance increase local concentration, significantly improving collision efficiency between electrogenerated free radicals. Consequently, DEAET NCs exhibited record stable anodal ECL without addition an exogenous co-reactant, dramatically superior classical Ru(bpy)32+ certain amount co-reactant. As proof concept, convenient label-free CE biosensor was innovatively constructed 1-naphthyl acetate selective substrate, achieving ultrasensitive detection low limit 9.1 × 10–7 U/L. Therefore, this work paves strategy preparation high-efficiency metal provides platform HCC.

Language: Английский

Citations

10