ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(4)
Published: Jan. 26, 2024
Abstract
We
report
the
development
of
a
convenient
organocatalytic
method
for
synthesis
5
H
‐pyrano[3,2‐
c
]chromenes
from
chromone‐containing
acrylates
and
ethyl
cyanoacetate.
The
is
characterized
by
simple
conditions
(ethanol,
basic
catalysis)
good
yields
(up
to
90
%).
synthesized
pyrano[3,2‐
are
promising
new
class
fluorescent
compounds.
They
have
intense
fluorescence
in
yellow‐green
region
spectrum
(495–554
nm)
with
high
quantum
72
%)
exhibit
large
Stokes
shifts
(3514–5856
cm
−1
).
demonstrated
possible
application
obtained
as
selective
“turn‐off”
sensors
nucleophilic
anions,
such
cyanide,
sulfide
sulfite.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4683 - 4703
Published: Jan. 31, 2024
Organic
fluorescent
molecules
with
emission
in
the
second
near-infrared
(NIR-II)
biological
window
have
aroused
increasing
investigation
cancer
phototheranostics.
Among
these
studies,
Benzobisthiadiazole
(BBT),
high
electron
affinity,
is
widely
utilized
as
acceptor
constructing
donor–acceptor–donor
(D-A-D)
structured
fluorophores
intensive
(NIR)
absorption
and
NIR-II
fluorescence.
Until
now,
numerous
BBT-based
dyes
been
employed
tumor
phototheranostics
due
to
their
exceptional
structure
tunability,
biocompatibility,
photophysical
properties.
This
review
systematically
overviews
research
progress
of
small
molecular
focuses
on
molecule
design
bioapplications.
First,
engineering
strategies
fine-tune
properties
high-performance
are
discussed
detail.
Then,
applications
optical
imaging
phototherapy
highlighted.
Finally,
current
challenges
future
prospects
also
summarized.
believed
significantly
promote
further
BBT-derived
for
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(16)
Published: Feb. 26, 2024
Bacterial
infections
have
emerged
as
the
leading
causes
of
mortality
and
morbidity
worldwide.
Herein,
we
developed
a
dual-channel
fluorescence
"turn-on"
sensor
array,
comprising
six
electrostatic
complexes
formed
from
one
negatively
charged
poly(para-aryleneethynylene)
(PPE)
positively
aggregation-induced
emission
(AIE)
fluorophores.
The
6-element
array
enabled
simultaneous
identification
20
bacteria
(OD
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(18)
Published: April 28, 2023
Near-infrared
fluorescence
imaging
is
vital
for
exploring
the
biological
world.
The
short
emissions
(<650
nm)
and
small
Stokes
shifts
(<30
of
current
xanthene
dyes
obstruct
their
applications
since
a
long
time.
Recently,
potent
universal
THQ
structural
modification
technique
that
emission
to
NIR-I/II
range
enables
substantial
shift
(>100
THQ-modified
established.
Thus,
timely
discussion
THQ-xanthene
its
extensive.
Hence,
advent,
working
principles,
development
trajectory,
dyes,
especially
in
fields
probe-based
sensing
imaging,
cancer
theranostics,
super-resolution
are
introduced.
It
envisioned
tactic
simple
yet
exceptional
approach
upgrade
performance
conventional
dyes.
will
advance
strides
xanthene-based
potentials
early
fluorescent
diagnosis
diseases,
imaging-guided
surgery.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(20), P. 6131 - 6138
Published: May 10, 2024
Accurate
intraoperative
tumor
delineation
is
critical
to
achieving
successful
surgical
outcomes.
However,
conventional
techniques
typically
suffer
from
poor
specificity
and
low
sensitivity
are
time-consuming,
which
greatly
affects
decision-making.
Here,
we
report
a
cascade
activatable
near-infrared
fluorescent
(NIRF)
probe
IR780SS@CaP
that
can
sequentially
respond
acidity
elevated
glutathione
levels
for
accurate
localization.
Compared
with
nonactivatable
single-factor
probes,
strategy
minimize
nonspecific
activation
false
positive
signals
in
complicated
biological
environment,
affording
superior
tumor-to-normal
tissue
ratio
facilitate
the
of
abdominal
metastases.
Small
metastatic
lesions
were
less
than
1
mm
diameter
be
precisely
identified
by
completely
excised
under
NIRF
imaging
guidance.
This
study
could
benefit
diagnosis
image-guided
surgery
providing
real-time
information
reliable
decision
support,
thus
reducing
risk
both
recurrence
complications
improve
patient
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Near-infrared
fluorescence
imaging
is
key
in
biological
exploration.
Short
emission
wavelengths
of
xanthene
dyes
limit
their
use.
Structural
modifications
shift
emissions
to
the
NIR-I/II
range,
enhancing
biomedical
applications.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
136(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
