Progress in the Application of Novel Nanomaterials in Targeted Therapy for Liver Cancer DOI Creative Commons
Xin Wei,

Weihua Cao,

Shiyu Wang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2623 - 2643

Published: March 1, 2025

In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties low toxicity, good tolerance, biocompatibility, and biodegradability new nanomaterials, a drug delivery system (TDDS) has been constructed, which can boost therapeutic effect hepatoma-targeted drugs, reduce minimize off target reactions by enhancing permeability retention (EPR) active targeting, thus existing liver cancer therapy strategies. Different nanoparticles have their own advantages disadvantages. They be loaded with multiple drugs on same nanoparticle also surface modified each other to achieve synergistic anti-tumor effects. This essay provides comprehensive overview current status hepatocarcinoma, nanoparticles' structure, disadvantages nanoparticle, application progress cancer. We hope provide basis future clinical hepatoma using nanotechnology.

Language: Английский

Exploring treatment options in cancer: Tumor treatment strategies DOI Creative Commons
Beilei Liu, Hongyu Zhou, Licheng Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 17, 2024

Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive remarkable transformation. Emerging fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, gene therapy. These cutting-edge not only afford personalized precise targeting, but also provide enhanced comfort potential to impede disease progression. Nonetheless, it is acknowledged that these strategies still harbour untapped for further advancement. Gaining understanding merits limitations holds promise offering novel perspectives clinical practice foundational research endeavours. In this review, we discussed different modalities, including drugs, peptide antibody cell therapy, It will detailed explanation each method, addressing their status development, challenges, solutions. The aim assist clinicians researchers in gaining deeper diverse options, enabling them carry out effective advance more efficiently.

Language: Английский

Citations

206
Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression DOI Creative Commons

Chenyang Zheng,

Bo Zhang, Yunyun Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(22)

Published: June 17, 2023

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Donafenib a multi‐receptor tyrosine kinase inhibitor approved for treatment patients with advanced HCC, but its clinical effect very limited. Here, through integrated screening small‐molecule library and druggable CRISPR library, that GSK‐J4 synthetically donafenib in liver cancer shown. This synergistic lethality validated multiple HCC models, including xenograft, orthotopically induced patient‐derived organoid models. Furthermore, co‐treatment resulted cell death mainly via ferroptosis. Mechanistically, RNA sequencing (RNA‐seq) assay transposase‐accessible chromatin high throughput (ATAC‐seq) analyses, synergistically promoted expression HMOX1 increased intracellular Fe2+ level found, eventually leading to Additionally, cleavage under targets & tagmentation followed by (CUT&Tag‐seq), it found enhancer regions upstream promoter significantly co‐treatment. A chromosome conformation capture confirmed caused enhanced interaction between dual‐drug combination. Taken together, this study elucidates new cancer.

Language: Английский

Citations

67
Ferroptosis: principles and significance in health and disease DOI Creative Commons
Fangquan Chen, Rui Kang, Daolin Tang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 6, 2024

Abstract Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic pathway in 2012, ferroptosis has emerged crucial mechanism numerous physiological pathological contexts, leading to significant therapeutic advancements across wide range diseases. This review summarizes the fundamental mechanisms regulatory pathways underlying ferroptosis, including both GPX4-dependent -independent antioxidant mechanisms. Additionally, we examine involvement various conditions, cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, metabolic disorders. Specifically, explore role response chemotherapy, radiotherapy, immunotherapy, nanotherapy, targeted therapy. Furthermore, discuss pharmacological strategies for modulating potential biomarkers monitoring this process. Lastly, elucidate interplay between other forms regulated death. Such insights hold promise advancing our understanding context human health disease.

Language: Английский

Citations

58
A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer DOI Creative Commons
Li Zhao, Fei Chang, Yao Tong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction may develop primary or acquired resistance. Further, multidrug combination used to prevent this in clinic places significant burden on patients. To address issue, work develops nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) exceptional near-infrared (NIR) absorption capability, small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This realizes targeted delivery multiple therapeutic effects, including chemo-and photothermal activities, oxidative stress, immune response. In vitro assays reveal HCT-modified nanoparticles exhibit specific recognition ability effective internalization by cells. The released PYR inhibit cell proliferation downregulating HER2 its associated pathways. NIR laser application induces effect tumor apoptosis, whereas an intracellular reactive oxygen species burst amplifies stress triggers cancer ferroptosis. Importantly, multimodal therapy also promotes upregulation genes related TNF NF-κB signaling pathways, enhancing activation immunogenic death. vivo studies confirm reduction volume after treatment, substantiating potential effectiveness these nanocarriers.

Language: Английский

Citations

21
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke DOI Creative Commons
Ru Li, Riqing Wei,

Chenxin Liu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3983 - 4000

Published: May 13, 2024

With the escalating prevalence of global heat waves, stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms injury, stroke-induced damage is characterized by cytotoxicity and heightened inflammation, directly contributing elevated mortality rates. While clinical assessments have identified bilirubin levels as indicative Kupffer cell dysfunction, their specific correlation with injury remains unclear. Our hypothesis proposes involvement ferroptosis during stroke, initiating IL-1

Language: Английский

Citations

11
Recent progress of ferroptosis in cancers and drug discovery DOI Creative Commons
Xiang Wang, Xinxin Ren, Xu Lin

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(4), P. 100939 - 100939

Published: June 26, 2024

Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation. involved in range pathological processes, such as cancer. Many studies have confirmed that ferroptosis plays an essential role inhibiting cancer proliferation. In addition, series small-molecule compounds been developed, including erastin, RSL3, FIN56, which can be used inducers. The combination inducers with anticancer drugs produce significant synergistic effect treatment, patients treated these combinations exhibit better prognosis than receiving traditional therapy. Therefore, thorough understanding the roles great significance for treatment This review mainly elaborates molecular biological characteristics mechanism ferroptosis, summarizes function development treatment,illustrates application patient's prediction drug discovery, discusses prospects targeting ferroptosis.

Language: Английский

Citations

9
Programmed cell death in hepatocellular carcinoma: mechanisms and therapeutic prospects DOI Creative Commons

Xiang’an Wu,

Jingying Cao,

Xueshuai Wan

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 8, 2024

Hepatocellular Carcinoma (HCC), the most common primary liver cancer, ranks as third cause of cancer-related deaths globally. A deeper understanding cell death mechanisms in HCC is essential for developing more effective treatment strategies. This review explores programmed (PCD) pathways involved HCC, including apoptosis, necroptosis, pyroptosis, ferroptosis, and immunogenic (ICD). These trigger specific cascades that influence development progression HCC. Although multiple PCD are shared cellular factors suggest a possible interplay between different forms death. However, exact roles which pathway plays major role remain unclear. also highlights how disruptions related to drug resistance cancer therapy, promoting combined approach induction anti-tumor enhance therapeutic efficacy. Further research required unravel complex modalities may lead innovative breakthroughs.

Language: Английский

Citations

9
Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis DOI

Chuyu Wang,

Ying Zhao,

Yingfei Peng

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156417 - 156417

Published: Jan. 1, 2025

Language: Английский

Citations

1
Multi‐Enzyme Activity of MIL‐101 (Fe)‐Derived Cascade Nano‐Enzymes for Antitumor and Antimicrobial Therapy DOI
Mengmeng Sun, Liling Wang, Yong Zhuo

et al.

Small, Journal Year: 2023, Volume and Issue: 20(17)

Published: Dec. 21, 2023

Abstract The clinical application of oncology therapy is hampered by high glutathione concentrations, hypoxia, and inefficient activation cell death mechanisms in cancer cells. In this study, Fe Mo bimetallic sulfide nanomaterial (FeS 2 @MoS ) based on metal‐organic framework structure rationally prepared with peroxidase (POD)‐, catalase (CAT)‐, superoxide dismutase (SOD)‐like activities depletion ability, which can confer versatility for treating tumors mending wounds. the lesion area, FeS SOD‐like activity facilitate transformation anions (O − to hydrogen peroxide (H O ), then resulting H serves as a substrate Fenton reaction FMS produce highly toxic hydroxyl radicals ( ∙ OH). Simultaneously, has an ability deplete (GSH) catalyze decomposition nicotinamide adenine dinucleotide phosphate (NADPH) curb regeneration GSH from source. Thus it realize effective tumor elimination through synergistic apoptosis‐ferroptosis strategy. Based alteration system, free radical production, alleviation hypoxia microenvironment, NPS not only significantly inhibit vivo vitro, but also multidrug‐resistant bacteria hasten wound healing. It may open door development cascade nanoplatforms treatment overcoming infection.

Language: Английский

Citations

22
NFE2L2 and ferroptosis resistance in cancer therapy DOI Open Access
Daolin Tang, Rui Kang

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key in the cellular defense against oxidative stress, playing crucial role cancer cell survival and resistance to therapies. This review outlines current knowledge on link between NFE2L2 ferroptosis - form of regulated death characterized by iron-dependent lipid peroxidation within cells. While activation can protect normal cells from damage, its overexpression contributes drug upregulating antioxidant defenses inhibiting ferroptosis. We delve into molecular pathways ferroptosis, highlighting involvement target genes, such

Language: Английский

Citations

8