Glucose Responsive Coacervate Protocells from Microfluidics for Diabetic Wound Healing DOI Creative Commons
Chong Wang,

Yang Xin-yuan,

Qiao Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: May 20, 2024

Abstract The hyperglycemic pathophysiological environment in diabetic wounds is a major obstacle that impedes the healing process. Glucose‐responsive wound materials are promising approach to address this challenge. In study, complex coacervate‐based protocells introduced for healing. By employing microfluidic chip with an external mechanical vibrator, uniform coacervate microdroplets generated via electrostatic interactions between diethylaminoethyl‐dextran and double‐stranded DNA. spontaneous assembly of phospholipid membrane on droplet surface enhances its biocompatibility. Glucose oxidase copper peroxide nanodots integrated into microdroplets, enabling glucose‐responsive cascade produces hydroxyl radicals as antibacterial agents. These features contribute efficient activity mice. present facilitate intelligent management, design catalytic coacervates can development various smart vehicles drug delivery.

Language: Английский

A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers DOI
Xiaoliang Qi,

Yizuo Shi,

Chaofan Zhang

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

Citations

67
Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing DOI
Meijiao Zhao,

Miaomiao Kang,

Jingru Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 1, 2024

Abstract Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic requires both generation ROS to inhibit bacteria subsequent reduction levels initiate promote tissue regeneration, which calls for more intelligent regulation dressing system. Hence, dual‐layered hydrogel (Dual‐Gel) tailored repair is designed: inner layer (Gel 2) first responds bacterial hyaluronidase (Hyal) deliver aggregation‐induced emission photosensitizer functionalized adipose‐derived stem cell nanovesicles, generate upon light irradiation eliminate bacteria; then outer 1) continuously starts long‐lasting consumption excess at site accelerate regeneration. Simultaneously, nanovesicles trapped burns also provide nutrients mobilize neighboring tissues thoroughly assist inflammation regulation, proliferation, migration, angiogenesis. In summary, this study develops an treatment approach on by programmatically regulating facilitating comprehensive

Language: Английский

Citations

65
Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management DOI Creative Commons
Li Wang, Guopu Chen, Lu Fan

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)

Published: March 22, 2023

Hard-healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend achieve multistage promotion real-time reporting facilitate management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for healing, which is intergated with glucose oxidase (GOD) copper peroxide (CP). Such are composed of biofriendly hyaluronic acid methacryloyl (HAMA) pH-responsive acrylic (AA), provided abundant binding sites spaces chemical immobilizing doping enzymes metal bioinorganics. When the catalytic applied on sites, hyperglycemia environment would serve as hydrogen (H2 O2 ) generator through GOD catalysis, while acidic triggers decomposition CP, further catalyzing H2 generate reactive oxygen species (ROS). Additionally, distinctive structural color can visually reflect pH intelligently estimate healing state. It demonstrated that such microparticle systems exhibit excellent broad-spectrum antibacterial angiogenesis-promoting properties, well significant ability healing. These features indicate possess valuable potential in related field.

Language: Английский

Citations

59
Genetically Edited Cascade Nanozymes for Cancer Immunotherapy DOI
Jing Zhang,

Yuanwei Pan,

Lujie Liu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12295 - 12310

Published: May 2, 2024

Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and infiltration cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy promote DC maturation elicit T-cell immunity, whereas low levels ICD induction solid tumors restrict durable antitumor efficacy. Herein, we report a genetically edited membrane-coated cascade nanozyme (gCM@MnAu) for enhanced cancer immunotherapy by inducing activating the stimulator interferon genes (STING) pathway. In tumor microenvironment (TME), gCM@MnAu initiates reaction generates abundant hydroxyl (•OH), resulting in improved chemodynamic therapy (CDT) boosted activation. addition, released Mn

Language: Английский

Citations

29
Stimuli‐Responsive Hydrogels for Antibacterial Applications DOI
Zhe Hao, Xiyan Li, Ruizhong Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

Citations

24
Self-Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management DOI Creative Commons
Li Wang,

Xiaoya Ding,

Lu Fan

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 2, 2024

Abstract Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances. It is vital to develop multifunctional hydrogel dressings, with well-designed morphology structure enhance flexibility effectiveness in wound management. To achieve these, we propose self-healing dressing based on structural color microspheres for The microsphere comprised photothermal-responsive inverse opal framework, which was constructed by hyaluronic acid methacryloyl, silk fibroin methacryloyl black phosphorus quantum dots (BPQDs), further re-filled dynamic hydrogel. filler formed Knoevenagel condensation reaction between cyanoacetate benzaldehyde-functionalized dextran (DEX-CA DEX-BA). Notably, the composite can be applied arbitrarily, they adhere together upon near-infrared irradiation leveraging BPQDs-mediated photothermal effect thermoreversible stiffness change Additionally, eumenitin vascular endothelial growth factor were co-loaded their release behavior regulated same mechanism. Moreover, effective monitoring drug process achieved through visual variations. system has demonstrated desired capabilities controllable efficient These characteristics suggest broad prospects proposed clinical applications.

Language: Английский

Citations

19
Recent advances of hydrogels as smart dressings for diabetic wounds DOI
Xu Wang, Yuhan Yang, Weifeng Zhao

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

Citations

18
Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing DOI Creative Commons

Yuheng Liao,

Zhenhe Zhang,

Yanzhi Zhao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

Citations

16
Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing DOI Creative Commons

Xuehao Tian,

Yuting Wen, Zhongxing Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

Citations

4
Developing conductive hydrogels for biomedical applications DOI Creative Commons
Yu Wang, Jiahui Guo, Xinyue Cao

et al.

Smart Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: Sept. 15, 2023

Conductive hydrogels have attracted copious attention owing to their grateful performances, such as similarity biological tissues, compliance, conductivity and biocompatibility. A diversity of conductive been developed showed versatile potentials in biomedical applications. In this review, we highlight the recent advances hydrogels, involving various types functionalities well applications fields. Furthermore, current challenges reasonable outlook are also given. It is expected that review will provide potential guidance for advancement next-generation hydrogels.

Language: Английский

Citations

27