Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Hydrogel
microspheres
are
important
in
regenerative
medicine
and
tissue
engineering,
acting
as
cargos
of
cells,
drugs,
growth
factors,
bio‐inks
for
3D
printing,
medical
devices.
The
antimicrobial
anti‐inflammatory
characteristics
hydrogel
good
treating
injured
tissues.
However,
the
biological
properties
should
be
modified
optimal
treatment
various
body
parts
with
different
physiological
biochemical
environments.
In
addition,
specific
preparation
methods
required
to
produce
customized
shapes
sizes
clinical
applications.
Herein,
advances
biomedical
applications
reviewed.
Synthesis
precursor
solutions,
manufacturing
methods,
strategies
enhancing
functions
these
described.
involvement
bioactive
repair
is
also
discussed.
This
review
anticipates
fostering
more
insights
into
design,
production,
application
biomedicine.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(10)
Published: Oct. 1, 2024
ABSTRACT
Nanogels
represent
a
significant
innovation
in
the
fields
of
nanotechnology
and
biomedical
engineering,
combining
properties
hydrogels
nanoparticles
to
create
versatile
platforms
for
drug
delivery,
tissue
bioimaging,
other
applications.
These
nanoscale
hydrogels,
typically
ranging
from
10
1000
nm,
possess
unique
characteristics
such
as
high
water
content,
biocompatibility,
ability
encapsulate
both
hydrophilic
hydrophobic
molecules.
The
review
explores
synthesis,
structural
configurations,
stimuli‐responsive
nature
nanogels,
highlighting
their
adaptability
targeted
including
across
challenging
barriers
like
blood–brain
barrier.
Furthermore,
paper
delves
into
applications
particularly
delivery
systems,
demonstrating
potential
revolutionize
these
fields.
Despite
promising
preclinical
results,
challenges
remain
translating
technologies
clinical
practice,
issues
related
stability,
scalability,
regulatory
approval.
concludes
by
discussing
future
perspectives,
emphasizing
need
further
research
optimize
ultimately
aiming
enhance
efficacy
safety
settings.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Extracellular
vesicles
(EVs)
are
heterogeneous
membrane-like
secreted
by
living
cells
that
involved
in
many
physiological
and
pathological
processes
act
as
intermediaries
of
intercellular
communication
molecular
transfer.
Recent
studies
have
shown
EVs
from
specific
sources
regulate
tissue
repair
regeneration
delivering
proteins,
lipids,
nucleic
acids
to
target
signaling
molecules.
Nanotechnology
breakthroughs
facilitated
the
development
exploration
engineered
for
repair.
Enhancements
through
gene
editing,
surface
modification,
content
modification
further
improved
their
therapeutic
efficacy.
This
review
summarizes
potential
regeneration,
mechanisms
action,
research
progress
regenerative
medicine.
highlights
design
logic
typical
examples
explores
prospects
The
aim
this
is
provide
new
insights
into
applications,
thereby
expanding
use
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 28, 2025
Abstract
Hydrogel
drug-delivery
system
that
can
effectively
load
antibacterial
drugs,
realize
the
in-situ
drug
release
in
microenvironment
of
wound
infection
to
promote
healing.
In
this
study,
a
multifunctional
hydrogel
delivery
(HA@TA-Okra)
was
constructed
through
integration
hyaluronic
acid
methacrylate
(HAMA)
matrix
with
tannic
(TA)
and
okra
extract.
The
composition
structural
characteristics
HA@TA-Okra
its
unique
advantages
treatment
diverse
wounds
were
systematically
evaluated.
TA,
due
chemical
structure,
is
able
anchor
within
HAMA
network
interactions
cross-linking,
conferring
exceptional
mechanical
strength
stability
hydrogel.
Both
TA
extract
possess
antioxidant
properties,
when
they
two
acts
synergistically
scavenge
free
radicals,
enhance
action,
diminishing
risk
infection.
vitro
experiments
revealed
has
superior
such
as
rapid
gel
response,
remarkable
swelling
regulation,
potent
ability.
Furthermore,
significantly
outperformed
conventional
dressings
terms
hemostatic
performance
rat
hemorrhage
model.
We
further
evaluated
repair
role
vivo
by
establishing
an
animal
model
full-thickness
skin
defects
infected
total
defects.
results
confirmed
positive
effects
fighting
bacterial
infection,
reducing
inflammation
promoting
summary,
exhibits
comprehensive
properties
antibacterial,
which
potential
application
field
tissue
medicine.
Graphical
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
The
microenvironment
of
diabetic
wounds
is
exceptionally
complex,
characterized
notably
by
persistent
bacterial
infections
and
the
excessive
production
reactive
oxygen
species
(ROS).
Traditional
treatment
methods
often
fall
short
achieving
ideal
results.
Consequently,
there
an
urgent
need
to
develop
implement
more
advanced
efficient
strategies
effectively
address
complexity
recalcitrance
wounds.
This
study
pioneers
a
novel
approach
fabricating
silk
fibroin-based
nonwoven
dressing
(SF-Ag-HCA)
under
neutral
conditions,
integrating
silver
ions
with
dihydrocaffeic
acid-modified
fibroin.
Uniquely,
this
achieves
dual
functionality:
exceptional
antibacterial
efficacy
against
common
pathogens
(E.
coli,
S.
aureus,
P.
aeruginosa)
robust
ROS-scavenging
capabilities,
mitigating
oxidative
stress
promoting
immune
homeostasis.
SF-Ag-HCA
not
only
surpasses
conventional
materials
in
regulating
wound
but
also
accelerates
re-epithelialization
collagen
deposition.
Animal
studies
further
validate
its
superior
performance
healing
infected
compared
commercial
alternatives.
innovative
represents
significant
advancement
care,
offering
integrated,
cost-effective
solution
tailored
for
complex
chronic
management.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: June 25, 2024
Emerging
infectious
diseases
like
coronavirus
pneumonia
(COVID-19)
present
significant
challenges
to
global
health,
extensively
affecting
both
human
society
and
the
economy.
Extracellular
vesicles
(EVs)
have
demonstrated
remarkable
potential
as
crucial
biomedical
tools
for
COVID-19
diagnosis
treatment.
However,
due
limitations
in
performance
titer
of
natural
vesicles,
their
clinical
use
remains
limited.
Nonetheless,
EV-inspired
strategies
are
gaining
increasing
attention.
Notably,
biomimetic
inspired
by
EVs,
possess
specific
receptors
that
can
act
"Trojan
horses,"
preventing
virus
from
infecting
host
cells.
Genetic
engineering
enhance
these
enabling
them
carry
more
receptors,
significantly
specificity
absorbing
novel
coronavirus.
Additionally,
inherit
numerous
cytokine
parent
cells,
allowing
effectively
mitigate
"cytokine
storm"
adsorbing
pro-inflammatory
cytokines.
Overall,
this
strategy
offers
new
avenues
treatment
emerging
diseases.
Herein,
review
systematically
summarizes
current
applications
COVID-19.
The
status
associated
with
implementation
also
discussed.
goal
is
provide
insights
into
design
expand
application
combating
