Advances in Hydrogel-Based Drug Delivery Systems

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 262 - 262

Published: April 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Language: Английский

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Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 26, 2024

Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable possesses outstanding properties. incorporating providing potential contrast magnetic resonance imaging observation, can propel reconfiguration enhance properties underwater due water‐initiated release Fe 3+ . vitro experiments show that hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, alleviated inflammation. effect ultimately demonstrated long urethral injury model vivo, achieves effective functional replacement accurate remodeling epithelium. Notably, proposed strategy provides advanced alternative treatment patients need large‐area epithelial reconstruction.

Language: Английский

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Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic materials, which successfully used for orthopedic and dental applications, with several products already approved clinical use. Apart from exhibiting osteogenic properties, BG also known to be angiogenic antibacterial. Recently, BG's role in immunomodulation has been gradually revealed. While the therapeutic effect mostly reported context bone skin-related regeneration, its application regenerating other tissues/organs, such as muscle, cartilage, gastrointestinal tissue, explored recently. The strategies applying have expanded powder or cement form more advanced fabrication composite polymer-BG scaffold, 3D printing BG-loaded BG-induced extracellular vesicle production. This review presents concise overview recent applications regenerative medicine. Various will first introduced. Next, various bone, tendon, skin, discussed. Finally, summarizing tissue regeneration conclude, outline future challenges directions translation BG.

Language: Английский

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Yeast-Inspired Orally-Administered Nanocomposite Scavenges Oxidative Stress and Restores Gut Immune Homeostasis for Inflammatory Bowel Disease Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Excessive oxidative stress, dysregulated immune homeostasis, and disruption of the intestinal epithelial barrier are crucial features inflammatory bowel disease (IBD). Traditional treatments focusing solely on inflammation resolution remain unsatisfactory. Herein, a yeast-inspired orally administered nanocomposite was developed. First, MD@MPDA core fabricated by integrating manganese dioxide (MnO2) nanozymes onto diallyl trisulfide (H2S prodrug)-loaded mesoporous polydopamine nanoparticles (MPDA). Then, yeast cell wall (YCW) chosen to encapsulate MD@MPDA, namely, YMD@MPDA. The β-glucan embedded in YCW shell not only protected from harsh gastrointestinal environment but also allowed targeting enrichment inflamed colon. Furthermore, M1 macrophages triggered intracellular GSH-responsive H2S release pathological microenvironment. effectively alleviated responses MnO2-mediated ROS-scavenging H2S-participated immunomodulation. synergistic action contributed macrophage mitochondrial function restoration M2 polarization suppressing NOX4 signaling p38 MAPK pro-inflammatory signaling. In mice model dextran sulfate sodium (DSS)-induced IBD, multipronged manner scavenging remodeling innate adaptive reshaping gut microbiota caused YMD@MPDA ameliorated restored functions. Overall, provides promising codelivery strategy antioxidative gas prodrugs for comprehensive management IBD.

Language: Английский

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Oral Delivery of Bioactive Glass‐Loaded Core–Shell Hydrogel Microspheres for Effective Treatment of Inflammatory Bowel Disease

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 24, 2023

Resolving inflammation and promoting intestinal tissue regeneration are critical for inflammatory bowel disease (IBD) treatment. Bioactive glass (BG) is a clinically approved bone graft material has been shown to modulate response, but it unknown whether BG can be applied treat IBD. Here, reported that attenuates pro-inflammatory response of lipopolysaccharide (LPS)-stimulated macrophages hence reduces damage organoids in vitro. In addition, zein/sodium alginate-based core-shell microspheres (Zein/SA/BG) developed oral delivery BG, which helps prevent premature dissolution the stomach. The results show Zein/SA/BG protects from gastric-simulated environment while dissolved an intestinal-simulated environment. When administered acute chronic colitis mice model, significantly inflammation, promotes epithelial regeneration, partially restores microbiota homeostasis. These findings first reveal therapeutic efficacy against IBD, may provide new approach at low cost effective IBD

Language: Английский

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Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 43 - 65

Published: April 17, 2024

Language: Английский

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Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

Science Advances, Journal Year: 2024, Volume and Issue: 10(30)

Published: July 26, 2024

The artificial mucus layer, such as hydrogels, used to repair the damaged intestinal barrier, is a promising treatment for inflammatory bowel disease (IBD). However, currently reported hydrogel-based barriers are administered via rectal injection, causing unnecessary discomfort patients. Herein, we report an oral hydrogel precursor solution based on thiol-modified hyaluronic acid (HASH). Owing reactive oxygen species (ROS)–responsive gelling behavior, our formed coating over inflamed regions of intestines, blocking microbial invasion and reducing abnormally activated immune responses. Notably, HASH also modulated gut microbiota, including increasing diversity enhancing abundance short-chain fatty acid–associated bacteria, which play key role in homeostasis. We believe that ROS-responsive layer strategy IBD.

Language: Английский

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Dental pulp regeneration strategies: A review of status quo and recent advances

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 258 - 275

Published: May 7, 2024

Microorganisms, physical factors such as temperature or mechanical injury, and chemical free monomers from composite resin are the main causes of dental pulp diseases. Current clinical treatment methods for diseases include root canal therapy, vital therapy regenerative endodontic therapy. Regenerative serves purpose inducing regeneration new functional tissues through autologous revascularization tissue engineering. This article first discusses current reviews strategies well research outcomes regarding regeneration. Then in vivo models, prospects challenges were further discussed.

Language: Английский

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Porphyra haitanensis polysaccharide-functionalized selenium nanoparticles for effective alleviation of ulcerative colitis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127570 - 127570

Published: Oct. 20, 2023

Language: Английский

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Fabrication of Core-Shell Hydrogel Bead Based on Sodium Alginate and Chitosan for Methylene Blue Adsorption

JOURNAL OF RENEWABLE MATERIALS, Journal Year: 2024, Volume and Issue: 12(4), P. 815 - 826

Published: Jan. 1, 2024

A novel core-shell hydrogel bead was fabricated for effective removal of methylene blue dye from aqueous solutions.The core, made sodium alginate-g-polyacrylamide and attapulgite nanofibers, cross-linked by Calcium ions (Ca 2+ ).The shell, composed a chitosan/activated carbon mixture, then coated onto the core.Fourier transform infrared spectroscopy confirmed grafting polymerization acrylamide alginate.Scanning electron microscopy images showed structure.The core exhibited high water uptake ratio, facilitating diffusion into core.During process, first adsorbed shell further core.Adsorption tests that coreshell structure had larger adsorption capacity than alone.The effectively enhanced to compared single core.Methylene activated chitosan in residual diffused adsorbed.

Language: Английский

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