Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics DOI Creative Commons
Shan Li, Tianyu Wu, Jingfeng Wu

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Oct. 15, 2024

The gastrointestinal tract (GIT) is an important and complex system by which humans to digest food absorb nutrients. GIT vulnerable diseases, may led discomfort or even death in humans. Therapeutics for disease treatment face multiple biological barriers, significantly decrease the efficacy of therapeutics. Recognizing barriers pathophysiological characteristics be helpful design innovative Nanotherapeutics, have special targeting controlled therapeutic release profiles, been widely used diseases. Herein, we provide a comprehensive review barrier GIT, aid promising nanotherapeutics treatment. Furthermore, several typical diseases upper lower digestive tracts, such as

Language: Английский

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics DOI Creative Commons
A. Chen, Ying Gong,

S. C. Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

3
Date seeds polysaccharides as novel capping agents for selenium nanoparticles: Synthesis, characterization, stability, biological activities, and gut microbiota modulation DOI
Athira Jayasree Subhash, Gafar Babatunde Bamigbade, M. Z. Abdin

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 470, P. 142746 - 142746

Published: Jan. 2, 2025

Language: Английский

Citations

2
Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis DOI Creative Commons

Xianguang Zhao,

Yixin Yu, Xudong Xu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy

Language: Английский

Citations

2
Combining Gut Microbiota Modulation and Enzymatic-Triggered Colonic Delivery by Prebiotic Nanoparticles Improves Mouse Colitis Therapy DOI Creative Commons
Hui Li, Yu Ti Cheng, Luwen Cui

et al.

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

The efficacy of ulcerative colitis (UC) therapy is closely connected to the composition gut microbiota in gastrointestinal tract. Prebiotic-based nanoparticles (NPs) provide a more precise approach alleviate UC via modulating dysbiosis. present study develops an efficient prebiotic-based colon-targeted drug delivery system (PCDDS) by using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as shell, with anti-inflammatory sulfasalazine (SAS) loaded into poly(lactic-co-glycolic acid) (PLGA) core construct SAS@PLGA-Csn-Pcn NPs. Then, we examine its characterization, cellular uptake, vivo therapeutic efficacy. results our indicate that Pcn/Csn shell confers pH-sensitivity properties. microbiota-secreted pectinase serves trigger agent for degradation, resulting Pcn oligosaccharides possess substantial property. Meanwhile, formed PCDDSs exhibit robust biodistribution accumulation colon tissue, rapid efficacy, modulation dysbiosis mouse model. Collectively, synthetic demonstrate promising synergistic strategy therapy.

Language: Английский

Citations

4
L‐Arginine‐Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis DOI Open Access
Shuaiwen Li, Zihui Chen, Minyu Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability gut lack of targeting, hindering precise intervention at lesion site. study prepares an L-Arginine-modified selenium nanozyme (Se-CA) for targeted oral treatment UC. Se-CA specifically targets M1-type macrophages sites by binding cationic amino acid transporter protein 2 on surface macrophages. In vitro studies show that scavenges nitrogen (RNS) artificial gastric fluids, inhibits iron death cells. mice model ulcerative colitis, administration is effective through its anti-inflammatory properties, inhibition regulation flora. conclusion, this work provides new insights into

Language: Английский

Citations

0
Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials DOI Creative Commons
Zetian Wang,

Ningning Hu,

Longqiu Yang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that has long plagued patients. Herein, an innovative oral treatment strategy for IBD proposed, which utilizes calcium alginate hydrogel as carrier to deliver Co3O4 nanocages loaded with total glucosides of paeony (TGP) into the body. This design ingeniously exploits protective properties outer layer ensure enzyme not prematurely degraded when passing through acidic gastric juice. However, upon reaching inflamed intestinal site, overexpressed H2O2 there mixes specific solution, causing degrade and release Co3O4@TGP. These negatively charged nanozymes can precisely recognize accumulate in colonic tissue, achieving targeted therapy their unique charge characteristics. More importantly, itself possesses excellent catalytic activity, effectively consuming excess at site inflammation degrading 10 nm small particles process, while simultaneously releasing TGP. Together, they exert dual effects scavenging reactive oxygen species (ROS) anti-inflammation. Its therapeutic mechanism involves fine regulation expression key proteins such TLR7, MYD88, GAPDH, well effective inhibition NF-κB signaling pathway. series actions only reduces various pro-inflammatory cytokines (such TNF-α, IL-18, IL-1β, IL-6, HMGB1) but also promotes production anti-inflammatory cytokine IL-10, thereby maintaining integrity barrier. research achievement opens up novel path colitis.

Language: Английский

Citations

0
Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery DOI
Xiangang Wan,

Caijie Zhang,

Pengyu Lei

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3245 - 3269

Published: Jan. 1, 2025

This review discusses ROS-responsive nanoparticles in IBD therapy, highlighting challenges, solutions, and the “layered programmable delivery” strategy for enhanced drug delivery localized treatment.

Language: Английский

Citations

0
Research progress on edible mushroom polysaccharides as a novel therapeutic strategy for inflammatory bowel disease DOI
Yating Song,

Yuqin Feng,

Guishan Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140994 - 140994

Published: Feb. 1, 2025

Language: Английский

Citations

0
Orally Administered ZnxCeyO2/Se Hydrogel with Effective Antioxidant Activity for Treating Inflammatory Bowel Disease by Inhibiting Ferroptosis DOI

Lingling Kan,

Tongsheng Li, Weinan Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Oxidative stress leads to intestinal barrier damage, which induces immune responses occur and further promotes oxidative exacerbating inflammatory bowel disease (IBD). In this work, the multifunctional Zn x Ce y O 2 /Se (ZCSO) nanozyme wrapped with acid‐resistant calcium alginate hydrogel designed for oral administration is prepared. The ZCSO can promote activation of Nrf2 pathway, then significantly improve efficiency scavenging reactive oxygen species (ROS) up‐regulate protein expression glutathione peroxidase 4 (GPx4), closely related inhibition ferroptosis. addition, inhibiting growth some pathogenic bacteria proliferating due shows a positive regulation flora reduces secretion pro‐inflammatory factors levels macrophages, achieving significant preventive delayed therapeutic effect colitis mice. Consequently, distinctive properties render it promising candidate treatment IBD by effectively ROS, thereby interrupting detrimental cycle between response, ultimately promoting proliferation epithelial cells reestablish integrity mucosal barrier.

Language: Английский

Citations

0
A “Janus” structured nanoclay microgel system for targeted probiotic therapy in diarrhea-predominant irritable bowel syndrome DOI Creative Commons
Youhe Wu,

Yiheng Jiang,

Yanrong Gong

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 383, P. 113769 - 113769

Published: April 23, 2025

Language: Английский

Citations

0