Illuminating oral health: AIEgens for phototheranostics

Published: March 1, 2025

Language: Английский

---

A “three-in-one” thermosensitive gel system that enhances mucus and biofilm penetration for the treatment of vulvovaginal candidiasis

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113666 - 113666

Published: March 1, 2025

Language: Английский

---

Vaginal mycobiome characteristics and therapeutic strategies in vulvovaginal candidiasis (VVC): differentiating pathogenic species and microecological features for stratified treatment

Clinical Microbiology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

SUMMARY Vulvovaginal candidiasis (VVC) is a prevalent global health burden, particularly among reproductive-aged women. Recurrent VVC affects significant proportion of this population, presenting therapeutic challenges. The predominant pathogen, Candida albicans , opportunistically transitions from commensal organism to pathogen when microenvironmental conditions become dysregulated. Recently, non- species have gained attention for their reduced antifungal susceptibility and recurrence tendencies. Diagnosis constrained by the limitations conventional microbiological techniques, while emerging molecular assays offer enhanced detection yet lack established thresholds differentiate between pathogenic states. Increasing resistance issues are encountered traditional azole-based antifungals, necessitating innovative approaches that integrate microbiota modulation precision medicine. Therefore, review aims systematically explore diversity, drug mechanisms, biofilm effects species. Vaginal (VMB) alterations associated with were also examined, focusing on interaction Lactobacillus spp. fungi, emphasizing role microbial dysbiosis in disease progression. Finally, potential summarized, particular focus use probiotics modulate VMB composition restore healthy ecosystem as promising treatment strategy. This addresses adopts microbiota-centric approach, proposing comprehensive framework personalized management reduce improve patient outcomes.

Language: Английский

---

Phototheranostics: An Advanced Approach for Precise Diagnosis and Treatment of Gynecological Inflammation and Tumors

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123012 - 123012

Published: Dec. 15, 2024

Language: Английский

---

Aggregation‐Induced Emission Photosensitizer‐Armored Magnetic Nanoparticles for Sepsis Treatment: Combating Multidrug‐Resistant Bacteria and Alleviating Inflammation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)

Published: Nov. 22, 2023

Abstract Sepsis, a life‐threatening condition stemming from an uncontrolled host immune response to bacterial infections, continues impose significant global burden with high morbidity and mortality. Addressing the challenges posed by antimicrobial resistance uncontrollable inflammation remains challenge in sepsis treatment. Moreover, traditional antibacterial materials have low trapping efficiency inevitable prolonged circulation within bloodstream, resulting suboptimal effects, metabolic complications, undesirable side effects. In this study, innovative solution is introduced through development of Fe 3 O 4 @SH@TBTCP‐PMB, aggregation‐induced emission (AIE) photosensitizer (PS)‐armored magnetic nanoparticles (NPs). It has reactive oxygen species (ROS) generation exceptional ability capture Gram‐positive bacteria over 80% enrichment just 1 h, even at concentrations. Under white light illumination, 100 µg mL −1 @SH@TBTCP‐PMB effectively eliminated more than 99.9% methicillin‐resistant Staphylococcus aureus (MRSA). Furthermore, its separation properties efficiently prevent systemic blood associated Most importantly, demonstrates superior anti‐inflammatory effects regulating cytokines, reducing adhesion molecule expression, managing oxidative stress levels. This multifunctional approach significantly enhances survival rates, offering promising strategy for combating multidrug‐resistant (MDR) infections patients while addressing inflammation‐related complications.

Language: Английский

---

Regulation of Charge Transfer Pathway in Ag‐ZnIn₂S₄ Nanowires for Visible Photodynamic Therapy on Candida Albicans Infections

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Photodynamic therapy (PDT) is receiving extensive attention as an antimicrobial strategy that does not cause drug resistance by reactive oxygen species (ROS). Herein, hierarchical Ag‐ZnIn 2 S 4 (Ag‐ZIS) core‐shell nanowires are synthesized in situ Metal‐Organic Framework derived method for efficient PDT of Candida albicans (C. albicans). The structure enables spatial synergy to regulate the charge transfer pathway under visible light excitation, which Ag like highway photogenerated electrons. enhanced carrier separation efficiency greatly increased chances generation ROS. As expected, optimized Ag‐ZIS exhibit excellent performance inactivation C. irradiation ( λ ≥ 420 nm, 15 min), and effective sterilization concentration high 10 7 CFU mL ‐1 . Moreover, vivo infection experiments suggested effect on mouse wound healing better than clinical Ketoconazole drug. antifungal mechanism also investigated, superoxide anion found be predominant active causes damage. This work provides a new perspective designing novel interface structures achieve therapy.

Language: Английский

---

Copper‐infused zinc porphyrin supramolecular polymersomes for triple synergistic combat against wound bacterial biofilm infections

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Bacterial biofilm infections (BBI) on wound surfaces and implants pose a significant clinical challenge due to the impermeable nature of biofilms obstacles in tissue repair. Traditional photothermal therapy (PTT) or chemodynamic (CDT), whether used alone combination, often causes damage surrounding normal tissues from high operating temperatures elevated levels reactive oxygen species, leading unsatisfactory anti‐biofilm effects. This study introduces novel copper ions loaded zinc porphyrin polymer vesicle (Cu‐PPS) that employs triple synergistic approach involving PTT, CDT, bacterial cuproptosis‐like death (BCD). Cu‐PPS exhibits exceptional efficiency 51.06%, promoting release under stimulation, enhancing CDT BCD effectiveness, facilitating mature clearance achieves bactericidal rate exceeding 99% an 93.32% vitro also excellent efficacy treating BBI vivo. presents innovative therapeutic strategy for combating infections, addressing challenges encountered management BBI.

Language: Английский

---

Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail lead persistent recurrent infections. The main culprits are 1) bacteria reviving, colonizing, rejuvenating biofilms, 2) secondary pathogen exposure, particularly in individuals with chronic diseases. Addressing how inhibit revival prevent reinfection simultaneously is still a major challenge. Herein, an oligo-ethylene glycol-modified lipophilic cationic photosensitizer (PS), TBTCP-PEG7, developed. It effectively eradicates Methicillin-Resistant Staphylococcus aureus (MRSA) under light irradiation. Furthermore, TBTCP-PEG7-mediated photodynamic therapy (PDT) not only conquers stubborn by downregulating the two-component system (TCS), quorum sensing (QS), virulence factors, thereby reducing intercellular communication, inhibiting bacterial regrowth remodeling but also prevents upregulating heat shock protein-related genes induce immunogenetic cell death (ICD) establish immune memory. In vivo, TBTCP-PEG7 efficiently MRSA adhered medical catheters, stimulates angiogenesis, reduces inflammatory factor expression, accelerates wound healing. ICD promotes short-term long-term immunological memory for coping This two-pronged strategy overcomes stubborn, infection, provides theoretical guidance designing next generation of antibacterial materials.

Language: Английский

---

An AIE Fungal Vacuole Membrane Probe toward Species Differentiation, Vacuole Formation Visualization, and Targeted Photodynamic Therapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101329 - 101329

Published: Nov. 6, 2024

Vacuoles are unique organelles of fungi. The development probes targeting the vacuoles membrane will enable visualization physiological processes and precise diagnosis therapy. Herein, a zwitterionic molecule, MXF-R, comprising an aggregation-induced emission (AIE) photosensitizing unit antibiotic moxifloxacin, was found capable specifically imaging vacuole using for targeted antifungal MXF-R demonstrated higher signal-to-noise ratio, stronger capability, better biocompatibility than commercial probe FM4-64. By real-time formation during Candida albicans (C. albicans) proliferation achieved. More importantly, owing to its varying staining ability towards different fungus, could be used quickly identify C. in mixed strains by fluorescence imaging. Moreover, exhibits remarkable generate reactive oxygen species under white light, effectively eradicating disrupting structure. This therapy damage is more effective clinical drug fluconazole. Therefore, this work not only presents initial discovery vacuolar membrane, but also provides way develop novel materials realize integrated

Language: Английский

---