A Visual Raman Nano−Delivery System Based on Thiophene Polymer for Microtumor Detection DOI Creative Commons
Meng Li,

Aoxiang Luo,

Wei Xu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 655 - 655

Published: May 14, 2024

A visual Raman nano-delivery system (NS) is a widely used technique for the visualization and diagnosis of tumors various biological processes. Thiophene-based organic polymers exhibit excellent biocompatibility, making them promising candidates development as NS. However, materials based on thiophene face limitations due to their absorption spectra not matching with NIR (near-infrared) excitation light, which makes it difficult achieve enhanced properties also introduces potential fluorescence interference. In this study, we introduce donor–acceptor (D-A)-structured thiophene-based polymer, PBDB-T. Due D-A molecular modulation, PBDB-T exhibits narrow bandgap Eg = 2.63 eV red-shifted spectrum, edge extending into region. Upon optimal 785 nm achieves ultra-strong pre-resonant enhancement while avoiding As an intrinsically sensitive NS in vivo imaging, enables microtumor regions dimensions 0.5 mm × 0.9 mm, successfully diagnoses deeper tumor tissues, circulation half-life 14.5 h. This research unveils application excited diagnosis, introducing new platform advancement “Visualized Drug Delivery Systems”. Moreover, aforementioned more diverse range targeted drug delivery methods, can be tailored specific regions.

Language: Английский

Cancer Cell‐Specific Fluorescent Prodrug Delivery Platforms DOI Creative Commons
Siyue Ma, Ji Hyeon Kim, Wei Chen

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(16)

Published: April 7, 2023

Abstract Targeting cancer cells with high specificity is one of the most essential yet challenging goals tumor therapy. Because different surface receptors, transporters, and integrins are overexpressed specifically on cells, using these cell‐specific properties to improve drug targeting efficacy holds particular promise. Targeted fluorescent prodrugs not only intracellular accumulation bioavailability but also report their own localization activation through real‐time changes in fluorescence. In this review, efforts highlighted develop innovative targeted that efficiently accumulate organs, including lung cancer, liver cervical breast glioma, colorectal cancer. The latest progress advances chemical design synthetic considerations fluorescence prodrug conjugates how therapeutic can be activated by tumor‐specific stimuli reviewed. Additionally, novel perspectives provided strategies behind engineered nanoparticle platforms self‐assembled from prodrugs, readouts used monitor position action nanoparticle‐mediated delivery agents preclinical models. Finally, future opportunities for prodrug‐based solutions challenges accelerating clinical translation treatment organ‐specific tumors proposed.

Language: Английский

Citations

29
Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials DOI Open Access
Md. Harun-Or-Rashid,

Most. Nazmin Aktar,

Md. Sabbir Hossain

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(23), P. 4563 - 4563

Published: Nov. 28, 2023

Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication strategies use biodegradable and bio-reducible polymers, progress the field been accelerated by future possible research applications. Natural polymers utilized polymeric systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic bioabsorbable as well biomimetic bio-related drug-free macromolecular therapies have employed delivery. Different synthetic natural biomaterials are clinical phase mitigate different diseases. Drug methods using becoming increasingly common pharmaceutical industry, with biocompatible copolymers dendrimers having helped cure cancer systems. This review discusses all above components how, combining biological approaches, micro- nano-drug can result revolutionary gene devices.

Language: Английский

Citations

28
Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging DOI Creative Commons
Yue Jiang, Min Zhao,

Jia Miao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 8, 2024

Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs) that instead utilize acidity-manipulated singlet oxygen ( 1 O 2 ) with enlarged thus possess more flexibility signal. After vitro validation of acidity-activated luminescence, ALCNs vivo 4T1-xenograft subcutaneous tumors female mice orthotopic liver male high signal-to-noise ratio (SNR). As representative targeting trial, Bio-ALCNs biotin modification prove the enhanced ability, sensitivity, specificity for pulmonary metastasis tumor via systemic administration mice, also implies potential broad utility diverse design flexibility. Therefore, this study provides innovative general approach better performance than fluorescence imaging.

Language: Английский

Citations

13
Hybrid adipocyte-derived exosome nano platform for potent chemo-phototherapy in targeted hepatocellular carcinoma DOI
Xinying Liu, Jiaxin Zhang,

Shunzhe Zheng

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 168 - 181

Published: April 24, 2024

Language: Английский

Citations

7
Brain gliomas: Diagnostic and therapeutic issues and the prospects of drug-targeted nano-delivery technology DOI Creative Commons

Baoqin Song,

Xiu Wang,

Lijing Qin

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107308 - 107308

Published: July 15, 2024

Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to heterogeneity invasiveness of tumors, lack personalized clinical design, physiological barriers, it often difficult accurately distinguish gliomas, which dramatically affects subsequent diagnosis, imaging treatment, prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities diagnosing treating gliomas recent years. They been modified surface efficiently traverse BBB/BBTB, target lesion sites, intelligently release therapeutic or contrast agents, thereby achieving precise treatment. In this review, we focus on systems. Firstly, provide an overview standard emerging diagnostic technologies for glioma practice. After induction analysis, summarizing delivery methods drug systems, design nanoparticles, their new advances Finally, discussed prospects potential challenges drug-delivery glioma.

Language: Английский

Citations

7
Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer DOI Open Access
Jiali Gong,

Danling Cheng,

Changcun Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Tumor immunotherapy represents a highly promising modality for the treatment of triple-negative breast cancer (TNBC). Nevertheless, its therapeutic efficacy has been profoundly impacted by challenges such as low drug uptake, hypoxia, and immunosuppression. To address these problems, study develops strategy combining sonodynamic therapy (SDT) using biomimetic nanoparticles coated with hybrid membranes. The are loaded semiconducting polymers (PFODBT), Atovaquone (ATO), TMP195 to enhance biocompatibility, targeting ability, uptake retention at tumor site. In in vitro experiments, alleviate induce immunogenic cell death (ICD), prompt reprogramming tumor-associated macrophages (TAMs) from M2 type M1 type. vivo synergistic effects enhanced SDT-mediated ICD TAMs repolarization significantly inhibit proliferation primary distant 4T1 subcutaneous model, effectively attenuated metastasis lung liver. Moreover, immune responses further activated improving maturation dendritic cells, filtration CD8

Language: Английский

Citations

5
Macrophage-modulating nanomedicine for cancer immunotherapy DOI
Muhammad Muzamil Khan, Yongjiang Li, Zhuoming Zhou

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(15), P. 7378 - 7386

Published: Jan. 1, 2024

We highlight the recent advances, discuss challenges, and propose future opportunities in nanomedicine-based strategies centered around macrophages for enhanced cancer immunotherapy.

Language: Английский

Citations

4
Biomimetic cell membrane decorated ZIF‐8 nanocarriers with IR‐780 and doxorubicin loading for multiple myeloma treatment DOI Creative Commons
Guangtao Gao, Junyi Che, Peipei Xu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Several therapeutic drugs including heptamethine cyanine dye (IR‐780), doxorubicin (DOX), and others have exhibited positive outcomes in the treatment of multiple myeloma (MM). However, curing MM is still hampered by undesired off‐target effects uncontrolled release therapeutics. Herein, we present novel MM‐mimicking nanocarriers integration DOX, IR‐780, cell membrane with zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles (D/INPs@CM) for treatment. The were fabricated co‐loading DOX IR‐780 into ZIF‐8 further coated membrane. After intravenous injection, D/INPs@CM can enter bone marrow target tumor cells owing to homing homologous targeting properties Once accumulating site, decomposed under acid microenvironment released encapsulated IR‐780. As a result, showed best eradication performance compared D/INPs, without displaying noticeable systemic toxicity. All these features suggest that our biomimetic may great potential precise targeted therapy related other hematological malignancies.

Language: Английский

Citations

4
Nanoscale strategies: doxorubicin resistance challenges and enhancing cancer therapy with advanced nanotechnological approaches DOI

Jian Xin Lim,

Yoke Keong Yong,

Firli Rahmah Primula Dewi

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

Citations

0
Advances in Targeted Therapy for Tumor with Nanocarriers: A Review DOI Creative Commons

Hongxia Cheng,

Juan Liao,

Yuhan Ma

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101583 - 101583

Published: Feb. 16, 2025

The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like imprecise delivery, poor bioavailability, high dose requirement, and tendency develop multidrug resistance. With protection NCs, drugs can reach lesion site then release accurately completely. Although some reviews have summarized biological applications little attention has been given advantages disadvantages analyzing organic, inorganic, hybrid NCs separately for targeted therapy identifying means further improve targeting ability. First, in this review, we emphasize three factors that marked impact on therapy: tumor microenvironment (TME), different administration modalities (intravenous, oral, intracavitary administration), pathways (passive active). Second, systematic examination polymeric dendrimers, micelles, liposomes, mesoporous silica gold quantum dots, nano clay, core-shell MOFs are reviewed. Further, propose ways efficiency therapy, including regulating size, shape, surface properties NCs.

Language: Английский

Citations

0