Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Abstract
Critical‐sized
bone
defects
represent
an
urgent
clinical
problem,
necessitating
innovative
treatment
approaches.
Gene‐activated
grafts
for
tissue
engineering
have
emerged
as
a
promising
solution.
However,
traditional
gene
delivery
methods
are
constrained
by
limited
osteogenic
efficacy
and
safety
concerns.
Recently,
organic
inorganic
nanoparticle
(NP)
vectors
attracted
significant
attention
in
their
safe,
stable,
controllable
delivery.
Targeted
guided
insights
into
healing
mechanisms,
coupled
with
the
multifunctional
design
of
NPs,
is
crucial
enhancing
therapeutic
outcomes.
Here,
theoretical
foundations
underlying
NP‐mediated
therapy
across
different
histological
stages
elucidated.
Furthermore,
distinct
attributes
functionalized
NP
discussed,
cutting‐edge
strategies
aimed
at
optimizing
efficiency
throughout
process
highlighted.
Additionally,
review
addresses
unresolved
challenges
prospects
this
technology.
This
may
contribute
to
continued
development
application
treating
critical‐sized
defects.
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(4), P. 533 - 533
Published: April 15, 2024
The
development
of
biomaterials
for
protein
delivery
is
an
emerging
field
that
spans
materials
science,
bioengineering,
and
medicine.
In
this
review,
we
highlight
the
immense
potential
protein-delivering
as
therapeutic
options
discuss
multifaceted
challenges
inherent
to
field.
We
address
current
advancements
approaches
in
leverage
stimuli-responsive
materials,
harness
advanced
fabrication
techniques
like
3D
printing,
integrate
nanotechnologies
greater
targeting
improved
stability,
efficacy,
tolerability
profiles.
also
demand
highly
complex
systems
maintain
structural
integrity
functionality
payload.
Finally,
barriers
clinical
translation,
such
biocompatibility,
immunogenicity,
achieving
reliable
controlled
release,
efficient
targeted
delivery,
stability
issues,
scalability
production,
navigating
regulatory
landscape
materials.
Overall,
review
summarizes
insights
from
a
survey
literature
sheds
light
on
interplay
between
innovation
practical
implementation
delivery.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7015 - 7057
Published: Oct. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
Polymers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 249 - 249
Published: Jan. 15, 2024
Polymeric
nanoparticles
(NPs),
utilized
extensively
in
biomedical
applications,
have
received
increasing
interest
the
preceding
years
and
today
represent
an
established
part
of
nanotechnology
field
[...].
