Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100863 - 100863
Published: Nov. 13, 2023
Non-healing
trauma,
with
limited
treatment
options,
remains
a
prevalent
complication
of
diabetes
mellitus.
The
underlying
causes
wherein
include
oxidative
stress
injury,
bacterial
infection,
cellular
dysfunction,
and
persistent
inflammation.
Acellular
Dermal
Matrix
(ADM),
wound
dressing
composed
natural
extracellular
matrix
abundant
bioactive
factors,
has
been
successfully
developed
to
treat
various
wounds,
including
burns
diabetic
ulcers.
Protocatechualdehyde
(PA)
&
trivalent
iron
ion
(Fe3+)
complex
(Fe3+@PA)
exhibits
potential
antioxidant
antibacterial
properties.
In
this
study,
we
dual
hydrogel
network
by
combining
Fe3+@PA
complex-modified
ADM
light-cured
gelatin
(GelMA),
supplemented
exosomes
derived
from
umbilical
vein
endothelial
cells
(HUVECs-Exos),
create
an
composite
system
(ADM-Fe3+@PA-Exos/GelMA)
antioxidant,
antibacterial,
cell-promoting
functions
for
treatment.
Through
in
vitro
experiments,
firstly
investigated
the
biosafety,
properties
hydrogel.
Furthermore,
examined
protective
effects
on
function
model.
animal
comprehensively
evaluated
therapeutic
wound.
above
experiments
collectively
demonstrate
that
our
ADM-Fe3+@PA-Exos/GelMA
reliably
overcomes
negative
factors
accelerates
healing,
which
provides
promising
strategy
optimize
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(22)
Published: May 18, 2023
Abstract
Treatment
of
infected
wounds
remains
a
challenge
owing
to
antibiotic
resistance;
thus,
developing
smart
biomaterials
for
the
healing
is
urgently
needed.
In
this
study,
microneedle
(MN)
patch
system
with
antimicrobial
and
immunomodulatory
properties
developed
promote
accelerate
wound
healing.
MN
(termed
PFG/M
MNs),
nanoparticle
polydopamine
(PDA)‐loaded
iron
oxide
grafted
glucose
oxidase
(GOx)
hyaluronic
acid
(HA)
then
integrated
into
tips,
amine‐modified
mesoporous
silica
nanoparticles
(AP‐MSNs)
are
incorporated
bases.
Results
show
that
MNs
eradicate
bacterial
infections
modulate
immune
microenvironment,
combining
advantages
chemodynamic
therapy,
photothermal
M2
macrophage
polarization
from
Fe/PDA@GOx@HA
in
tips
as
well
anti‐inflammatory
effect
AP‐MSNs
Thus,
promising
clinical
candidate
promoting
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(22)
Published: Feb. 1, 2024
Abstract
The
skin,
as
the
body's
largest
organ,
is
closely
linked
to
an
individual's
health.
Delayed
diagnosis
and
treatment
of
skin
infections
can
lead
complications
such
non‐healing
wounds
sepsis.
Despite
significant,
early
identification
wound
timely
remain
a
challenge
that
requires
continuous
management.
This
work
presents
novel
strategy
combines
smart
microneedle
sensing
inhibit
infection
track
healing
status.
tip
based
on
metal‐organic
frameworks
(MOF)
hydrogel
allows
rapid
self‐sterilization
promotes
healing.
substrate
patch
pH–sensitive
fluorescent
reagents,
integrate
with
smartphone
visualize
images.
Furthermore,
it
be
further
reliably
evaluated
pH
by
applying
machine‐learning
algorithm.
multifunctional
establishes
therapy
address
delayed
management,
design
optimization
MOF
hydrogels,
contributes
facile
way
for
disease
personalized
health
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: May 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 6, 2025
Abstract
The
use
of
microneedles
(MNs)
has
been
established
as
an
effective
transdermal
drug
delivery
strategy
that
extensively
deployed
for
treating
various
diseases,
including
skin
diseases.
MNs
can
surpass
the
constraints
conventional
methods
by
their
superior
safety
and
efficacy
through
precise
targeting,
while
simultaneously
enabling
painless
delivery.
Currently,
are
increasingly
used
carriers
delivery,
with
loading
insoluble
drugs
to
improve
treatment
efficiency
or
combining
bioactive
substances
construction
efficient
system
maximize
effects
substances.
preparation
diverse,
them
meet
requirements
most
applications.
emergence
addressed
shortcomings
associated
drugs,
expanded
applications
substances,
improved
in
clinical
practice.
This
review
summarizes
current
information
on
application
a
variety
such
psoriasis,
vitiligo,
alopecia,
hypertrophic
scarring,
atopic
dermatitis,
melanoma,
acne,
infections.
future
opportunities
diseases
also
discussed.
Despite
substantial
progress
vectors,
issues
low
poor
mechanical
strength
during
remain
main
challenges.
Therefore,
implementation
MNs-based
therapies
remains
limited,
highlighting
key
research.
