Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137401 - 137401
Published: March 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)
Published: Feb. 1, 2024
Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D ‐bioHJs) devised. Under ultrasonication, 2D ‐bioHJs effectively eliminate disrupting metabolism electron transport chain (ETC). When ultrasonication ceases, they enable elimination SPT‐generated ROS. The act as a “lever” that achieves balance between ROS generation annihilation, delivering both antibacterial anti‐inflammatory properties engineered membrane. More importantly, in vivo assays corroborate membranes transform stalled chronic environment into regenerative one eradicating bacterial population, dampening NF‐κB pathway promoting angiogenesis. As envisaged, this work demonstrates novel tactic arm with programmed effects remedy refractory wounds from drug‐fast bacteria.
Language: Английский
Citations
61
Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 17 - 30
Published: Jan. 21, 2024
Diabetic wounds has a gradually increasing incidence and morbidity. Excessive inflammation due to immune imbalance leads delayed wound healing. Here, we reveal the interconnection between activation of NLRP3 inflammatory pathway in endotheliocyte polarization macrophages via cGAS-STING oxidative microenvironment. To enhance immune-regulation based on repairing mitochondrial damage, zeolitic imidazolate framework-8 coated with cerium dioxide that carries Rhoassociated protein kinase inhibition Y-27632 (CeO2–Y@ZIF-8) is developed. It encapsulated photocross-linkable hydrogel (GelMA) cationic quaternary ammonium salt groups modified endow antibacterial properties (CeO2–Y@ZIF-8@Gel). CeO2 superoxide dismutase catalase activities can remove excess reactive oxygen species limit damage repair damaged DNA, thus improving proliferation endotheliocyte. After uptakes CeO2–Y@ZIF-8 NPs degrade peroxides into water cells mitochondria, inhibited leakage oxidatively DNA (Ox-mtDNA, damage-associated molecular pattern) through mPTP decreases. Futhermore, as activated by Ox-mtDNA down-regulated, M2 phenotype anti-inflammatory factors increase. Collectively, CeO2–Y@ZIF-8@Gel, remodulating crosstalk macrophage reprogramming angiogenesis alleviate microenvironment accelerates
Language: Английский
Citations
25
Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151
Published: Oct. 15, 2024
Language: Английский
Citations
18
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Abstract The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating hyperglycemia. pivotal anti‐pathogenic efficiency is focused on confined gradually weaken reactive oxygen species (ROS) yield peculiar micromilieu owing to materials transformation/dissolution. There, type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation proposed, which consisted by glucose oxidase (GOx) decorated type‐I FeSe 2 /Cu O heterojunction. It exhibits robust catalytic produce ROS. Followed, heterojunction can be transformed into dual Z‐scheme a composition /CuSe/Cu primed acid meliorative energy band. conducive NIR‐induced capabilities improve ROS yield. GOx consume H as an amplifier. combined followed enhanced powerfully remove colonization. On top that, sample downgrade Forkhead box (FoxO) signaling pathway regulate cell cycle, facilitate proliferation, further promote repairment. This work provides effective feasible antibacterial strategy way thinking for healing.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2023, Volume and Issue: 10(21)
Published: May 10, 2023
Abstract Antibacterial dynamic therapy (ADT) triggered by reactive oxygen species (ROS) is promising for diabetic infectious disease treatment. However, the limited local O 2 /H production and post‐treatment inflammation remain long‐standing issues. To address these challenges, a novel H ‐evolving bio‐heterojunction enzyme (Bio‐HJzyme) consisting of graphite‐phase carbon nitride/copper sulfide (CN/Cu 2− x S) heterojunction glucose oxidase (GO ) created. The Bio‐HJzyme offers glutathione peroxidase (GP ), (POD), catalase (CAT) mimetic activities; provides anti‐pathogen properties via programmed light activation; effectively promotes wound healing. Specifically, its GP ‐mimetic activity presence GO significantly enhance yield , which can be catalyzed through POD‐mimetic to produce highly germicidal •OH. also assisted CAT‐mimetic activity. products then into •OH •O − under NIR irradiation, giving enhanced ADT. Further, CN split water form solar light, dramatically suppresses caused excessive ROS. In vivo evaluation confirms that regeneration skin killing bacteria, enhancing angiogenesis, promoting bed epithelialization, reinforcing anti‐inflammatory responses; hence, providing revolutionary approach wounds
Language: Английский
Citations
40
Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122355 - 122355
Published: Nov. 4, 2023
Language: Английский
Citations
31
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(3), P. 3116 - 3125
Published: Jan. 15, 2024
High concentrations of reactive oxygen and nitrogen species (RONS) are key characteristics inflammatory sites. Scavenging RONS at the site inflammation is an effective therapeutic strategy. This study introduces ultrasmall Cu2O@His nanoparticles with RONS-scavenging ability for treatment bowel disease (IBD) in mice. The strong coordination between atom histidine (His) copper enhances dispersion stability Cu2O@His. Due to their small size large surface area, exhibits outstanding RONS-clearing ability. Importantly, can target mitochondrial sites repair damaged mitochondria. With excellent scavenging ability, demonstrates good efficacy treating mouse IBD. work provides a new paradigm developing nanozymes multiple abilities.
Language: Английский
Citations
14
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)
Published: Feb. 7, 2024
Skin injury is a common health problem worldwide, and the highly complex healing process poses critical challenges for its management. Therefore, wound dressings with salutary effects are urgently needed care. However, traditional dressing single function often fails to meet needs of repair, integration multiple functions has been required repair. Herein, Cu2+-chelated epigallocatechin gallate nanoparticles (EAC NPs), radical scavenging, inflammation relieving, bacteria restraining, vascularization accelerating capacities, adopted functionalize collagen scaffold, aiming promote healing. Radical scavenging experiments verify that EAC NPs could efficiently scavenge radicals. Additionally, effectively remove Escherichia coli Staphylococcus aureus. H2O2 stimuli-responsive show slow sustained release properties Cu2+. Furthermore, exhibit protective against H2O2-induced oxidative-stress damage anti-inflammatory activity in vivo. Physicochemical characterizations introduction does not disrupt gelation behavior collagen, composite scaffolds (CS) remain porous structure similar scaffold. Animal demonstrate CS through improving thickness renascent epidermis number new vessels. promising
Language: Английский
Citations
14
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205
Published: Sept. 11, 2024
Language: Английский
Citations
14
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 231 - 245
Published: Jan. 1, 2024
Background: As the first line of immune defense and largest organ body, skin is vulnerable to damage caused by surgery, burns, collisions other factors. Wound healing in a long complex physiological process that influenced number different Proper wound care can greatly improve speed reduce generation scars. However, traditional dressings (bandages, gauze, etc.) often used clinical practice have single function, lack active ingredients are limited use. Hydrogels with three-dimensional network structure potential biomedical material because their physical chemical environment similar extracellular matrix. In particular, hydrogel low price, good biocompatibility, degradability, antibacterial angiogenic activity favored public. Methods: Here, carboxymethyl chitosan-based dressing (CMCS-TA/Cu 2+ ) reinforced copper ion crosslinked tannic acid (TA/Cu nanoparticles was developed. This study investigated characteristics, cytotoxicity, angiogenesis TA/Cu CMCS-TA/Cu hydrogels. Furthermore, full-thickness defect model employed assess vivo capacity dressings. Results: The introduction not only could increase mechanical properties but also continuously releases ions promote cell migration (the reach 92% at 48 h) tubule formation, remove free radicals (repair rate 90% 9 days). Conclusion: Experiments proved has cytocompatibility, antioxidant ability, providing an advantageous solution for repair. Keywords: nanoparticles, chitosan, dressing,
Language: Английский
Citations
13