Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
With
the
improvement
of
implant
design
and
expansion
application
scenarios,
orthopedic
implants
have
become
a
common
surgical
option
for
treating
fractures
end‐stage
osteoarthritis.
Their
goal
is
rapidly
forming
long‐term
stable
osseointegration.
However,
this
fixation
effect
limited
by
surface
characteristics
peri‐implant
bone
tissue
activity.
Therefore,
review
summarizes
strategies
interface
engineering
(osteogenic
peptides,
growth
factors,
metal
ions)
treatment
methods
(porous
nanotubes,
hydrogel
embedding,
other
load‐release
systems)
through
research
on
its
biological
mechanism,
paving
way
to
achieve
adaptation
both
coordination
between
different
strategies.
transition
osseointegration
stage,
demonstrated
varying
therapeutic
effects.
Especially,
activity
osteoblasts
runs
almost
entire
process
osseointegration,
their
physiological
activities
play
dominant
role
in
formation.
Furthermore,
diseases
impacting
metabolism
exacerbate
difficulty
achieving
This
aims
assist
future
improve
implant‐bone
fixation,
promote
fracture
healing,
enhance
post‐implantation
recovery.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
The
dilemma
of
diabetic
infectious
wound
healing
lies
in
inhibiting
the
pathogenic
colonization
and
regulating
hyperglycemia.
pivotal
anti‐pathogenic
efficiency
is
focused
on
confined
gradually
weaken
reactive
oxygen
species
(ROS)
yield
peculiar
micromilieu
owing
to
materials
transformation/dissolution.
There,
type‐transformational
bio‐heterojunction
enzyme
(BioHJzyme)
with
operando
composition‐modulation
proposed,
which
consisted
by
glucose
oxidase
(GOx)
decorated
type‐I
FeSe
2
/Cu
O
heterojunction.
It
exhibits
robust
catalytic
produce
ROS.
Followed,
heterojunction
can
be
transformed
into
dual
Z‐scheme
a
composition
/CuSe/Cu
primed
acid
meliorative
energy
band.
conducive
NIR‐induced
capabilities
improve
ROS
yield.
GOx
consume
H
as
an
amplifier.
combined
followed
enhanced
powerfully
remove
colonization.
On
top
that,
sample
downgrade
Forkhead
box
(FoxO)
signaling
pathway
regulate
cell
cycle,
facilitate
proliferation,
further
promote
repairment.
This
work
provides
effective
feasible
antibacterial
strategy
way
thinking
for
healing.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: June 29, 2024
The
disorder
of
the
macrophage
phenotype
and
hostile
by-product
lactate
evoked
by
pathogenic
infection
in
hypoxic
deep
wound
inevitably
lead
to
stagnant
skin
regeneration.
In
this
study,
hydrogen
sulfide
(H
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 8, 2024
Abstract
The
repair
and
reconstruction
of
large‐scale
bone
defects
face
enormous
challenges
because
the
failure
to
reconstruct
osteo‐vascularization
network.
Herein,
a
near‐infrared
(NIR)
light‐responsive
hydrogel
system
is
reported
achieve
programmed
tissue
regeneration
through
synergetic
effects
on‐demand
drug
delivery
mild
heat
stimulation.
spatiotemporal
(HG/MPa)
composed
polydopamine‐coated
Ti
3
C
2
T
x
MXene
(MP)
nanosheets
decorated
with
acidic
fibroblast
growth
factor
(aFGF,
potent
angiogenic
drug)
hydroxypropyl
chitosan/gelatin
(HG)
developed
orchestrate
network
boost
regeneration.
Upon
exposure
NIR
light
irradiation,
engineered
HG/MPa
can
initial
complete
release
aFGF
induce
rapid
angiogenesis
provide
sufficient
blood
supply,
maximizing
its
biofunction
in
defect
area.
This
integrated
demonstrated
good
therapeutic
efficacy
promoting
cell
adhesion,
proliferation,
migration,
angiogenesis,
osteogenic
differentiation
periodic
irradiation.
In
vivo,
animal
experiments
further
revealed
that
spatiotemporalized
platform
synergized
photothermal
treatment
significantly
accelerated
critical‐sized
healing
by
increasing
density,
recruiting
endogenous
stem
cells,
facilitating
production
osteogenesis/angiogenesis‐related
factors.
Overall,
smart‐responsive
could
enhance
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(15), P. 17707 - 17718
Published: July 25, 2024
Wound-associated
infections
represent
an
arduous
global
healthcare
challenge,
especially
in
the
"post-antibiotic"
era,
necessitating
development
of
advanced
antimicrobial
dressing
materials
that
simultaneously
dictate
use
rapid
yet
effective
disinfection,
low
drug
resistance
and
side
effects,
potency
to
foster
tissue
healing.
Nanoantimicrobial-armored
nanostructured
functional
systems
have
piqued
extensive
interest
satisfy
these
criteria.
Herein,
fusing
electrospinning
nanotechnology
emerging
photo–chemo
synergistic
sterilization
paradigm,
a
smart
"all-in-one"
multifunctional
wound-managing
platform
was
constructed,
through
incorporating
photochemically
active
nanocrystalline
cuprous
oxide
(Cu2O)
into
modified
polycaprolactone
(mPCL)
electrospun
fibrous
mats.
The
resulting
were
systematically
characterized
pertaining
physiochemical
analysis,
photoabsorption
photocurrent
measurements,
photocatalytic
reactive
oxygen
species
(ROS)
generation.
capability
this
nanoplatform
elicit
rapid,
photoactivated,
catalytically
augmented
bacterial
disinfection
corroborated,
displaying
∼99–100%
broad-spectrum
antibacterial
efficacies
against
Staphylococcus
aureus
Escherichia
coli
25
min.
Benefiting
from
release
Cu2+,
mPCL-Cu2O
impairs
contamination
even
under
dark
conditions.
Furthermore,
also
exhibited
favorable
vitro/-ovo
biocompatibility
toward
NIH3T3
fibroblasts,
red
blood
cells,
chick
chorioallantoic
membrane,
alongside
appreciable
pro-healing
capacity
bridging
scratch-based
wounds,
which
could
be
attributed
nanofiber-afforded
biomimetic
topography
controllable
liberation
micronutrient
Cu
ions.
This
study
provides
insights
design
fabrication
simple
nanoplatforms
for
biomedical
applications.
