Washed microbiota transplantation stopped recurrent sepsis in a patient with myelofibrosis: a case report DOI Creative Commons

Yingqi Yang,

Luyao Wang,

Tianchi Zhuang

et al.

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 27, 2024

Sepsis represents the most prevalent infectious complication and primary cause of mortality in myeloproliferative neoplasms (MPN). The risk sepsis difficulty treatment are significantly increased MPN patients due to need for immunomodulators antibiotics. On June 9, 2023, a 69-year-old male was admitted hospital. Following battery tests, diagnosis Escherichia coli ultimately established. patient administered amoxicillin clavulanate potassium intravenously. In light patient's recurrent likelihood that source infection is intestinal tract, we advised undergo washed microbiota transplantation (WMT) via colonic transendoscopic enteral tube (TET). WMT as new method fecal (FMT) successfully cured this case, indicating novel option challenging refractory or serious infections.

Language: Английский

Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology DOI Creative Commons
Ana Isabel Beltrán-Velasco, Vicente Javier Clemente‐Suárez

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

Citations

2
The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome DOI Creative Commons

You Yu,

Weihong Wang, Faming Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)

Published: Nov. 1, 2023

Abstract Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis‐related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods mainly include washed spores treatment. Transplanting virome is also explored, with development transplantation, which involves filtering from feces. These approaches provide more palatable options patients healthcare providers while minimizing research heterogeneity. In general, evolution next generation global trends components focuses on

Language: Английский

Citations

24
Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis DOI
Xinpei Li,

Shijie Shang,

Meng Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217096 - 217096

Published: July 4, 2024

Language: Английский

Citations

11
The potential influence and intervention measures of gut microbiota on sperm: it is time to focus on testis-gut microbiota axis DOI Creative Commons
Wenkang Chen, Hede Zou, Haoran Xu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

As the global male infertility rate continues to rise, there is an urgent imperative investigate underlying causes of sustained deterioration in sperm quality. The gut microbiota emerges as a pivotal factor host health regulation, with mounting evidence highlighting its dual influence on semen. This review underscores interplay between Testis-Gut axis and consequential effects sperm. Potential mechanisms driving impact encompass immune modulation, inflammatory responses mediated by endotoxins, oxidative stress, antioxidant defenses, microbiota-derived metabolites, epigenetic modifications, regulatory sex hormone signaling. Interventions such probiotics, prebiotics, synbiotics, fecal transplantation, Traditional natural herbal extracts are hypothesized rectify dysbiosis, offering avenues modulate enhance Spermatogenesis motility. Future investigations should delve into elucidating foundational principles governing interaction within Axis. Understanding modulating Axis may yield novel therapeutic strategies fertility combat decline

Language: Английский

Citations

6
Gut microbiota as a biomarker and modulator of anti-tumor immunotherapy outcomes DOI Creative Commons

Jiexi Yan,

Lu Yang,

Qingmiao Ren

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 28, 2024

Although immune-checkpoint inhibitors (ICIs) have significantly improved cancer treatment, their effectiveness is limited by primary or acquired resistance in many patients. The gut microbiota, through its production of metabolites and regulation immune cell functions, plays a vital role maintaining balance influencing the response to immunotherapies. This review highlights evidence linking specific microbial characteristics increased therapeutic efficacy variety cancers, such as gastrointestinal melanoma, lung cancer, urinary system reproductive suggesting microbiota’s potential predictive biomarker for ICI responsiveness. It also explores possibility enhancing fecal microbiota transplantation, probiotics, prebiotics, synbiotics, postbiotics, dietary modifications. Moreover, underscores need extensive randomized controlled trials confirm value establish guidelines microbiota-targeted interventions immunotherapy. In summary, article suggests that balanced key maximizing immunotherapy benefits calls further research optimize modulation strategies treatment. advocates deeper comprehension complex interactions between host immunity, therapy, aiming more personalized effective treatment options.

Language: Английский

Citations

6
Gut microbiome-derived hydrolases—an underrated target of natural product metabolism DOI Creative Commons
Jiaxin He, Xiaofeng Liu, Junming Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: June 10, 2024

In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases relation to oral drug metabolism, particularly focusing on natural product drugs. Despite the significance of drugs field medications, is a lack research regulatory interplay between and these This review delves into interaction intestinal metabolism from three key perspectives. Firstly, it examines impact glycoside hydrolases, amide carboxylesterase, bile salt epoxide hydrolase structure products. Secondly, explores how influence hydrolases. Lastly, analyzes interactions products disease development challenges developing microbial-derived enzymes. The overarching goal this lay solid theoretical foundation for advancement new personalized treatment.

Language: Английский

Citations

4
Bacteriophages and their potential for treatment of metabolic diseases DOI Creative Commons

Youpeng Deng,

Shouwei Jiang,

Huawei Duan

et al.

Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(11)

Published: Nov. 1, 2024

Abstract Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart hyperlipidemia. While alterations bacteria are well‐documented, emerging evidence suggests that changes viruses also contribute to these disorders. Bacteriophages, most abundant viruses, influence bacterial populations through their lytic lysogenic cycles, potentially modulating ecosystem pathways. Phage therapy, previously overshadowed by antibiotics, is experiencing renewed interest due rising antibiotic resistance. It offers a novel approach precisely edit microbiota, with promising applications diseases. In this review, we summarize recent discoveries about virome disease patients, review preclinical clinical studies phage therapy on diseases well breakthroughs currently faced problems concerns. image

Language: Английский

Citations

4
Applications of bacteriophages in precision engineering of the human gut microbiome DOI Creative Commons

Xiaoxian Kuang,

Juntao Shen,

Linggang Zheng

et al.

Engineering Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 100189 - 100189

Published: Jan. 7, 2025

Language: Английский

Citations

0
Community characteristics and relationship between gut microbiota and intratumoral microbiota in hepatocellular carcinoma DOI Creative Commons
Hung-Wen Lin, Zhanshan Ma, Jin Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

The combination of local therapy with lenvatinib and programmed cell death protein-1 (PD-1) inhibitors represents an emerging treatment paradigm for unresectable hepatocellular carcinoma (uHCC). Our study sought to investigate the interrelationship between gut microbiota intratumoral in context triple therapy, a view identifying potential biological markers. microbial community profiles patients primary untreated (HCC) those treated combined PD-1 were analyzed by 16S rRNA gene amplicon sequencing. Additionally, tumor tissues HCC normal liver analyzed. In our investigation, we observed that who received exhibited notable enhancement abundance Actinobacteriota considerable decrease Escherichia Shigella. Patients hepatic artery infusion chemotherapy (HAIC) levatinib significantly elevated levels Faecalibacterium prausnitzii Bacteroides stercoris comparison transarterial chemoembolization (TACE) inhibitors. Furthermore, decline diversity was within tumors tissues. high degree similarity microbes present at phylum level. Gut is connected HCC. These discoveries underscore utilizing as biomarkers, well possibility management

Language: Английский

Citations

0
Modulation of Intestinal Flora: a Novel Immunotherapeutic Approach for Enhancing Thyroid Cancer Treatment DOI

Wei-Qiang Huang,

Tao Jiang, Jiaxuan He

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0